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Lapatinib ditosylate monohydrate

Lapatinib ditosylate monohydrate Structure
Lapatinib ditosylate monohydrate structure
CAS No.
388082-78-8
Chemical Name:
Lapatinib ditosylate monohydrate
Synonyms
Lapatinib ditosylate Monohydrate;Lapatinib tosilate;Lapatinib ditosylate hydrate;Lapatinb;GW2016 ditosylate;GW-572016;GW572016;(E)-Ferulic acid-d;lapatinib(GW572016);Lapatinib Ditosilate;xyene sulfonate lapatinib
CBNumber:
CB2966227
Molecular Formula:
C41H40ClFN4O11S3
Molecular Weight:
925.46
MDL Number:
MFCD09264195
MOL File:
388082-78-8.mol
MSDS File:
SDS
Last updated:2025-01-07 19:25:08
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Lapatinib ditosylate monohydrate Properties

Melting point >200oC (dec.)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
color Yellow
CAS DataBase Reference 388082-78-8(CAS DataBase Reference)
FDA UNII G873GX646R
NCI Dictionary of Cancer Terms lapatinib ditosylate
NCI Drug Dictionary lapatinib ditosylate

SAFETY

Risk and Safety Statements

Hazard statements  H413

Lapatinib ditosylate monohydrate price More Price(30)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC L175813 LapatinibDitosylateMonohydrate 388082-78-8 10mg $85 2021-12-16 Buy
Usbiological 281198 Lapatinib ditosylate 388082-78-8 50mg $375 2021-12-16 Buy
Usbiological 015474 Lapatinib Ditosylate 388082-78-8 5mg $425 2021-12-16 Buy
Matrix Scientific 090594 Lapatinib ditosylate hydrate 98% 388082-78-8 250mg $567 2021-12-16 Buy
Biorbyt Ltd orb180754 Lapatinib ditosylate >98% 388082-78-8 250mg $615.4 2021-12-16 Buy
Product number Packaging Price Buy
L175813 10mg $85 Buy
281198 50mg $375 Buy
015474 5mg $425 Buy
090594 250mg $567 Buy
orb180754 250mg $615.4 Buy

Lapatinib ditosylate monohydrate Chemical Properties,Uses,Production

Uses

binds to a(1), dopamine, histamine H1, muscarinic, and serotonin type 2 (5-HT2) receptors atypical antipsychotic agent

Uses

anticancer

Uses

Lapatinib ditosylate monohydrate is a form of Lapatinib I, an orally active drug for breast cancer as a dual EGFR and erbB-?2 inhibitor.

Definition

ChEBI: Lapatinib ditosylate monohydrate is a member of quinazolines.

General Description

Lapatinib is available in 250-mg tablets for oral administrationand is used in combination with cabecitabine in thetreatment of breast cancer for those patients that over expressthe type 2 EGF-R and who have previously receivedtaxane, anthracycline, and trastuzumab therapy. The type 2EGF-R is one subtype of this receptor and is also known asHER2 or ErbB-2. The agent is a receptor TK inhibitor targetingthe ErbB-1 and ErbB-2 subtypes. Binding occurs atthe ATP-binding site and thereby prevents phosphorylationand the subsequent activation of other kinase enzymes.ErbB-1 overexpression occurs in approximately27% to 30% of breast cancers, while ErbB-2 is over expressedin 20% to 25% of cases.The agent has demonstratedIC50 values of ＜0.2μM against ErbB-1 and 2 fromseveral different cancer cell lines and dissociates slowly(t1/2＝300 min) from these receptor TKs.The drug isboth a substrate and an inhibitor of the efflux transportersPgp and BCRP. It is also an inhibitor of the hepatic uptaketransporter OATP1B1, which is an organic anion transporter.The absorption of lapatinib is incomplete andvariable after oral administration. The agent is extensivelymetabolized by CYP3A4 and CYP3A5, with minor contributionsfrom CYP2C19 and CYP2C8. Lapatinib inhibitsCYP3A and CYP2C8 at clinically relevant concentrations.The agent is highly (99%) protein bound and eliminatedprimarily in the feces. The half-life of the agent increaseupon repeated dosing, taking 6 days to reach steady statethat gives an effective half-life of 24 hours. The most commonlyseen adverse effects of lapatinib therapy are skinrash and diarrhea. Skin rash is commonly seen with manyof the other TK inhibitors and agents that target ErbB-1.Lapatinib-induced diarrhea is usually mild to moderate.There have been reports of decreases in left ventricularejection fraction associated with the agent, although thisappears to occur only rarely and is reversible upon discontinuationof therapy.

target

EGFR

Lapatinib ditosylate monohydrate synthesis

49773-20-8
104-15-4
231278-84-5
388082-78-8
Synthesis of Lapatinib ditosylate monohydrate from 2-Aminoethylmethyl sulfone and p-Toluenesulfonic acid and 5-[4-((3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl]-2-furaldehyde

Lapatinib ditosylate monohydrate Preparation Products And Raw materials

Raw materials

5-[4-((3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl]-2-furaldehyde 2-Aminoethylmethylsulfone hydrochloride 2-Aminoethylmethyl sulfone p-Toluenesulfonic acid

Preparation Products

Lapatinib

Lapatinib ditosylate monohydrate Suppliers

Global( 366)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		+86-15531157085 +86-15531157085 abby@chuanghaibio.com China 8805 58
Hebei Mujin Biotechnology Co.,Ltd 		+86 13288715578 +8613288715578 sales@hbmojin.com China 12824 58
Hebei Yanxi Chemical Co., Ltd. 		+8617531153977 allison@yan-xi.com China 5855 58
HangZhou RunYan Pharma Technology Co.,LTD. 		+8618882027439 sales2@runyanpharma.com China 302 58
SHANDONG BOYUAN PHARMACEUTICAL CO., LTD. 		+86-0531-69954981 +8615666777973 dwyane.wang@boyuanpharm.com China 211 58
hebei hongtan Biotechnology Co., Ltd 		+852-6619 3215 +86-17731935328 sales03@chemcn.cn China 970 58
Apeloa production Co.,Limited 		+8619933239880 admin@apcl.com.cn China 861 58
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. 		+86-18600796368 +86-18600796368 sales@sjar-tech.com China 484 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29730 60
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1803 55
Supplier Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		58
Hebei Mujin Biotechnology Co.,Ltd 		58
Hebei Yanxi Chemical Co., Ltd. 		58
HangZhou RunYan Pharma Technology Co.,LTD. 		58
SHANDONG BOYUAN PHARMACEUTICAL CO., LTD. 		58
hebei hongtan Biotechnology Co., Ltd 		58
Apeloa production Co.,Limited 		58
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. 		58
Capot Chemical Co.,Ltd. 		60
Beijing Cooperate Pharmaceutical Co.,Ltd 		55

View Lastest Price from Lapatinib ditosylate monohydrate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Lapatinib ditosylate monohydrate pictures 2025-03-17 Lapatinib ditosylate monohydrate
388082-78-8
 US $0.00 / Kg/Drum 1Kg/Drum 99% 5000KG Hebei Mujin Biotechnology Co.,Ltd
Lapatinib ditosylate pictures 2025-03-17 Lapatinib ditosylate
388082-78-8
 US $0.00-0.00 / g 1g 99% HPLC 10000 HangZhou RunYan Pharma Technology Co.,LTD.
Lapatinib ditosylate pictures 2025-03-14 Lapatinib ditosylate
388082-78-8
 US $0.00 / KG 1KG 99% 50000KG/month Hebei Mujin Biotechnology Co.,Ltd

388082-78-8(Lapatinib ditosylate monohydrate)Related Search:

Lapatinib PENTA(ETHYLENE GLYCOL) DI-P-TOLUENESULFONATE Pazopanib Osimertinib mesylate Baricitinib
Afatinib 4-[4-[[[[4-Chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-2-pyridinecarboxamide hydrate Cabazitaxel Pazopanib Hydrochloride Regorafenib
Afatinib dimaleate AZD-9291 Nintedanib Ethanesulfonate Salt 2-mercapto-N-methylbenzamide N-[3-Chloro-4-(3-fluorobenzyloxy)phenyl]-6-iodoquinazolin-4-amine
5-[4-((3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl]-2-furaldehyde 2-Aminoethylmethylsulfone hydrochloride p-Toluenesulfonic acid

1of4

benzenesulfonic acid: N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6 -[5-[(2-methylsulfonylethylamino)methyl]-2-furyl]quinazolin-4-amine: h ydrate N-(3-Chloro-4-((3-fluorophenyl)methoxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)-2-furanyl)-4-quinazolinamine bis(4-methylbenzenesulfonate) Lapatinib Ditosilate Lapatinib, Tykerb, GW572016 Lapatinib Ditosylate (GW-572016) lapatinib(GW572016) bis(N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-(5-((2-(Methylsulfonyl)ethylaMino)Methyl)furan-2-yl)quinazolin-4-aMine) tetrakis(4-Methylbenzenesulfonate) hydrate Lapatinb 4-QuinazolinaMine, N-[3-chloro-4-[(3-fluorophenyl)Methoxy]phenyl]-6-[5-[[[2-(Methylsulfonyl)ethyl]aMino]Methyl]-2-furanyl]-, bis(4-Methylbenzenesulfonate), Monohydrate (9CI) N-(3-Chloro-4-((3-fluorophenyl)methoxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)-2-furanyl)-4-quinazolinamine bis(4-methylbenzenesulfonate) monohydrate 4-QuinazolinaMine, N-[3-chloro-4-[(3-fluorophenyl)Methoxy]phenyl]-6-[5-[[[2-(Methylsulfonyl)ethyl]aMino]Methyl]-2-furanyl]-, bis(4-Methylbenzenesulfonate), Monohydrate xyene sulfonate lapatinib (N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-(5-((2-(Methylsulfonyl)ethylaMino)Methyl)furan-2-yl)quinazolin-4-aMine)bis(4-Methylbenzenesulfonate) hydrate Lapatinib ditosylate N-(3-Chloro-4-((3-fluorophenyl)methoxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)-2-furanyl)-4-quinazolinamine bis(4-methylbenzenesulfonate) N-(3-Chloro-4-(3-fluorobenzyloxy)phenyl)-6-(5-((2-(methylsulfonyl)ethylamino)methyl)furan-2-yl)-quinazolin-4-ylamine ditosylate hydrate Rapatinib bis - toluene sulfonate GW-572016;GW572016 Lapatinib xylene sulfonate N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-4-quinazolinamine, 4-methylbenzenesulfonate, hydrate (1:2:1) Lapatinib Ditosylate MonohydrateI Lapatinib ditosylate hydrat Lapatinib ditoluenesulfonate monohydrate Lapatinib tosilate hydrate Lapatinib ditosylate ISO 9001：2015 REACH Lapatinib D4 DitosylateQ: What is Lapatinib D4 Ditosylate Q: What is the CAS Number of Lapatinib D4 Ditosylate Lapatinib tosilate Lapatinib ditosylate Monohydrate Lapatinib ditosylate hydrate Lapatinib p-toluenesulfonate monohydrate GW2016 ditosylate (E)-Ferulic acid-d Lapatinib ditosylate monohydrate|||Lapatinib ditoluenesulfonate monohydrate|||Lapatinib tosilate hydrate|||Lapatinib tosilate|||Tykerb|||Tyverb Lapatinib ditosylate monohydrate, 10 mM in DMSO 388082-78-8 388083-78-8 388082-78-9 C29H26ClFN4O4S2C7H8O3 C29H26ClFN4O4S2C7H8O3S C41H40ClFN4O11S3 C29H26ClFN4O4S2C74H8O3SH2O C29H26ClFN4O4S2C7H8O3SH2O C43H44ClFN4O11S3 2C7H8O3SC29H26ClFN4O4S anti-neoplastic Inhibitors Anti-cancer&immunity Lapatinib API 388082-78-8