BISINDOLYLMALEIMIDE I HYDROCHLORIDE
- CAS No.
- 176504-36-2
- Chemical Name:
- BISINDOLYLMALEIMIDE I HYDROCHLORIDE
- Synonyms
- BIS-I HCl;GO-6860 HCl;BIM 1 hydrochloride;GF 109203X hydrochloride >=95%;BisindolylMaleiMide I( Hydrochloride Salt);BisindolylMaleiMide I . hydrochloride [GF-109203K;GF 109203X hydrochloride, ATP-competitive PKC inhibitor;Bisindolylmaleimide I, Hydrochloride - CAS 176504-36-2 - Calbiochem;3-[1-(dimethylaminopropyl)indol-3-yl]-4-(indol-3-yl)maleimide hydrochloride;3-[1-[3-(dimethylamino)propyl]indol-3-yl]-4-(1H-indol-3-yl)pyrrole-2,5-dione
- CBNumber:
- CB2972282
- Molecular Formula:
- C25H25ClN4O2
- Molecular Weight:
- 448.95
- MDL Number:
- MFCD00236429
- MOL File:
- 176504-36-2.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P301+P310 |
| WGK Germany | 3 |
| HS Code | 2933998090 |
BISINDOLYLMALEIMIDE I HYDROCHLORIDE price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | B6292 | GF 109203X hydrochloride ≥95% | 176504-36-2 | 250μg | $80.7 | 2024-03-01 | Buy |
| Sigma-Aldrich | 203291 | Bisindolylmaleimide I, Hydrochloride An enhanced water-soluble form of Bisindolylmaleimide I. | 176504-36-2 | 1mg | $187 | 2024-03-01 | Buy |
| Sigma-Aldrich | 203291 | Bisindolylmaleimide I, Hydrochloride - CAS 176504-36-2 - Calbiochem An enhanced water-soluble form of Bisindolylmaleimide I. | 176504-36-2 | 250μg | $68.9 | 2023-06-20 | Buy |
| Sigma-Aldrich | 203291 | Bisindolylmaleimide I, Hydrochloride An enhanced water-soluble form of Bisindolylmaleimide I. | 176504-36-2 | 250ug | $65.2 | 2021-12-16 | Buy |
| Cayman Chemical | 21180 | Bisindolylmaleimide I (hydrochloride) ≥98% | 176504-36-2 | 500μg | $32 | 2024-03-01 | Buy |
BISINDOLYLMALEIMIDE I HYDROCHLORIDE Chemical Properties,Uses,Production
Description
Bisindolylmaleimide I (BIM I) is a highly selective, cell-permeable, and reversible PKC inhibitor (Ki = 14 nM) that is structurally similar to the poorly selective PKC inhibitor staurosporine . It acts as a competitive inhibitor for the ATP binding site of PKC and shows high selectivity for PKCα, β1, β2, γ, δ, and ε isozymes. BIM I directly inhibits glycogen synthase kinase 3 (GSK3) in primary adipocyte lysates (IC50 = 360 nM) and in GSK3β immunoprecipitates derived from rat epididymal adipocytes (IC50 = 170 nM). It also competitively antagonizes the serotonin (5-HT) receptor subtype 5-HT3 with a Ki value of 61 nM.
Uses
GF 109203X hydrochloride has been used to inhibit protein kinase C in human neuroblastoma-derived kelly cells.
General Description
GF 109203X prevents collagen-triggered adenosine and three phosphate (ATP) secretion. It also inhibits collagen and α-thrombin-induced platelet aggregation. It functions as an inhibitor of glycogen synthase kinase-3 (GSK-3). GF 109203X also functions as an anti-inflammatory agent.
Biochem/physiol Actions
Inhibitor of protein kinase C; potent inhibitor of GSK-3.
BISINDOLYLMALEIMIDE I HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
BISINDOLYLMALEIMIDE I HYDROCHLORIDE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32956 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57505 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51456 | 80 |
| Shanghaizehan biopharma technology co., Ltd. | 021-61350663 13052117465 | sales@zehanbiopharma.com | China | 1004 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9806 | 58 |
| Shanghai Chaolan Chemical Technology Center | 021-QQ：65489617 15618227136 | Sales@ATKchemical.com | China | 7295 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
| Taizhou Nanfeng Pharmaceutical Research Institute | 18616377689 | nanfengdrug@163.com | China | 20000 | 58 |
| ShangHai ChuanQian Chemcial Technique Centre | 15869524721 | 3525679403@qq.com | China | 4010 | 58 |