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BMS-P5

BMS-P5 structure

CAS No.: 1549811-36-0

Chemical Name:: BMS-P5

Synonyms: BMS-P5 HCL;NET,BMS P5,myeloma,inhibit,Peptidylarginine Deiminase,Inhibitor,Protein Arginine Deiminase,Multiple,BMS-P5,BMS-P-5,BMSP5;((2S,5S)-5-amino-2-methylpiperidin-1-yl)(2-(1-(cyclopropylmethyl)-1H-pyrrolo[2,3-b]pyridin-2-yl)-7-methoxy-1-methyl-1H-benzo[d]imidazol-5-yl)methanone hydrochloride

CBNumber:: CB29731093

Molecular Formula:: C27H33ClN6O2

Molecular Weight:: 509.05

MDL Number:: MFCD34471000

MOL File:: 1549811-36-0.mol

Last updated:2024-08-11 15:28:20

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BMS-P5 Properties

InChIKey	UMXWDEKCDIDCBA-TVJVWYQLNA-N
SMILES	C(C1CC1)N1C2=NC=CC=C2C=C1C1=NC2=CC(C(N3C[C@H](N)CC[C@@H]3C)=O)=CC(OC)=C2N1C.Cl \|&1:21,25,r\|

BMS-P5 Chemical Properties,Uses,Production

Description

BMS-P5 is a Novel Peptidylarginine Deiminase 4 (PAD4) Inhibitor with pIC50 values in the range of 5-?7.5. BMS-P5 Blocks Formation of Neutrophil Extracellular Traps and Delays Progression of Multiple Myeloma. Administration of BMS-P5 to multiple myeloma-bearing mice delays appearance of symptoms and disease progression Targeting PAD4 may be beneficial for treatment of multiple myeloma.

Biological Activity

BMS-P5 is an inhibitor of the protein arginine deiminase 4 (PAD4; IC50 = 0.098 μM). It is selective for PAD4 over PAD1, -2, and -3 (IC50s = >10 μM). BMS-P5 (1 μM) inhibits citrullination of histone H3 and neutrophil extracellular trap (NET) formation induced by RPMI-8226- or MM.1S-conditioned medium in isolated human neutrophils. It delays disease onset and increases survival in a DP42 syngeneic mouse model of multiple myeloma when administered at a dose of 50 mg/kg.

BMS-P5 Preparation Products And Raw materials

Raw materials

Preparation Products

BMS-P5 Suppliers

Global( 24)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hubei Chuchang Biotech Co., Ltd.	+undefined15623860702	info@chuchangbiotech.com	China	111	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10522	58
Hebei Miaoyin Technology Co.,Ltd	+86-17367732028 +86-17367732028	kathy@hbyinsheng.com	China	3581	58
Wuhan Jingkang en Biomedical Technology Co., Ltd	+8613720134139	orders@jknbiochem.com	China	5224	58
Hubei Chuchang Chemical Co., Ltd	15623560702	Joy.Ren@aliyun.com	China	145	58
ShangHai Angti Biotechnology Co., Ltd.	13764913901	info@angtibio.com	China	4956	55
Shanghai Rechem science Co., Ltd.	21-31433387 15618786686	sales@rechemscience.com	China	2965	58
Changzhou Chenhong Biotechnology Co., Ltd.	0519-85788828 13775037613	sales@chemrenpharm.com	China	3600	58
ShangHai ChuanQian Chemcial Technique Centre	15869524721	3525679403@qq.com	China	3715	58

Supplier	Advantage
Hubei Chuchang Biotech Co., Ltd.	58
TargetMol Chemicals Inc.	58
Zhejiang J&C Biological Technology Co.,Limited	58
Hebei Miaoyin Technology Co.,Ltd	58
Wuhan Jingkang en Biomedical Technology Co., Ltd	58
Hubei Chuchang Chemical Co., Ltd	58
ShangHai Angti Biotechnology Co., Ltd.	55
Shanghai Rechem science Co., Ltd.	58
Changzhou Chenhong Biotechnology Co., Ltd.	58
ShangHai ChuanQian Chemcial Technique Centre	58

View Lastest Price from BMS-P5 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-08-26	BMS-P5 1549811-36-0	US $0.00-0.00 / MG	1MG	98	100G	Hubei Chuchang Biotech Co., Ltd.

BMS-P5
1549811-36-0
US $0.00-0.00 / MG
98
Hubei Chuchang Biotech Co., Ltd.

NET,BMS P5,myeloma,inhibit,Peptidylarginine Deiminase,Inhibitor,Protein Arginine Deiminase,Multiple,BMS-P5,BMS-P-5,BMSP5 ((2S,5S)-5-amino-2-methylpiperidin-1-yl)(2-(1-(cyclopropylmethyl)-1H-pyrrolo[2,3-b]pyridin-2-yl)-7-methoxy-1-methyl-1H-benzo[d]imidazol-5-yl)methanone hydrochloride BMS-P5 HCL 1549811-36-0