Pyrrolo[2,1-b][1,3]oxazepine-7-carboxamide, octahydro-8,8-dimethyl-4-[[(2S)-2-(methylamino)-1-oxopropyl]amino]-5-oxo-N-[(1R)-1,2,3,4-tetrahydro-1-naphthalenyl]-, (4S,7S,9aS)-
- CAS No.
- 1422180-49-1
- Chemical Name:
- Pyrrolo[2,1-b][1,3]oxazepine-7-carboxamide, octahydro-8,8-dimethyl-4-[[(2S)-2-(methylamino)-1-oxopropyl]amino]-5-oxo-N-[(1R)-1,2,3,4-tetrahydro-1-naphthalenyl]-, (4S,7S,9aS)-
- Synonyms
- SBP-0636457;SBI-0636457;SB1-0636457;Pyrrolo[2,1-b][1,3]oxazepine-7-carboxamide, octahydro-8,8-dimethyl-4-[[(2S)-2-(methylamino)-1-oxopropyl]amino]-5-oxo-N-[(1R)-1,2,3,4-tetrahydro-1-naphthalenyl]-, (4S,7S,9aS)-
- CBNumber:
- CB29752571
- Molecular Formula:
- C25H36N4O4
- Molecular Weight:
- 456.58
- MDL Number:
- MOL File:
- 1422180-49-1.mol
Pyrrolo[2,1-b][1,3]oxazepine-7-carboxamide, octahydro-8,8-dimethyl-4-[[(2S)-2-(methylamino)-1-oxopropyl]amino]-5-oxo-N-[(1R)-1,2,3,4-tetrahydro-1-naphthalenyl]-, (4S,7S,9aS)- Properties
Boiling point | 733.0±60.0 °C(Predicted) |
---|---|
Density | 1.22±0.1 g/cm3(Predicted) |
storage temp. | 4°C, stored under nitrogen |
form | Solid |
pka | 13.92±0.60(Predicted) |
color | Off-white to yellow |
Pyrrolo[2,1-b][1,3]oxazepine-7-carboxamide, octahydro-8,8-dimethyl-4-[[(2S)-2-(methylamino)-1-oxopropyl]amino]-5-oxo-N-[(1R)-1,2,3,4-tetrahydro-1-naphthalenyl]-, (4S,7S,9aS)- Chemical Properties,Uses,Production
Biological Activity
SBP-0636457 (SB1-0636457) is a SMAC mimetic, and as an IAP antagonist. SBP-0636457 binds to the BIR-domains of the IAP proteins, with a Ki of 0.27 μM. SBP-0636457 can be used for the research of solid tumors and hematologic cancers[1][2]. SBP-0636457 (1-20 μM) demonstrates no cytotoxicity in BT474, BT549, MCF7, and MDA-MB-231 breast cancer cell lines up to a concentration of 20μM[1].SBP-0636457 (10-1000 nM; 20 h) is ef?cacious as TRAIL-sensitizing agents in MDA-MB-231 cells, with an EC50 of 9 nM[1].
References
[1]. Finlay D, et, al. Small-molecule IAP antagonists sensitize cancer cells to TRAIL-induced apoptosis: roles of XIAP and cIAPs. Mol Cancer Ther. 2014 Jan; 13(1): 5-15. [2]. Finlay D, et, al. Inducing death in tumor cells: roles of the inhibitor of apoptosis proteins. F1000Res. 2017 Apr 27; 6:587.
Pyrrolo[2,1-b][1,3]oxazepine-7-carboxamide, octahydro-8,8-dimethyl-4-[[(2S)-2-(methylamino)-1-oxopropyl]amino]-5-oxo-N-[(1R)-1,2,3,4-tetrahydro-1-naphthalenyl]-, (4S,7S,9aS)- Preparation Products And Raw materials
Raw materials
Preparation Products
Pyrrolo[2,1-b][1,3]oxazepine-7-carboxamide, octahydro-8,8-dimethyl-4-[[(2S)-2-(methylamino)-1-oxopropyl]amino]-5-oxo-N-[(1R)-1,2,3,4-tetrahydro-1-naphthalenyl]-, (4S,7S,9aS)- Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
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TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 19696 | 58 |
Supplier | Advantage |
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TargetMol Chemicals Inc. | 58 |