Urea, N-(3-chlorophenyl)-N'-(6-cyano-2-benzothiazolyl)-
- CAS No.
- 2387821-46-5
- Chemical Name:
- Urea, N-(3-chlorophenyl)-N'-(6-cyano-2-benzothiazolyl)-
- Synonyms
- HB007;HB-007,HB007;1-(3-Chlorophenyl)-3-(6-cyanobenzo[d]thiazol-2-yl)urea;Urea, N-(3-chlorophenyl)-N'-(6-cyano-2-benzothiazolyl)-
- CBNumber:
- CB29783269
- Molecular Formula:
- C15H9ClN4OS
- Molecular Weight:
- 328.78
- MDL Number:
- MFCD34578507
- MOL File:
- 2387821-46-5.mol
Urea, N-(3-chlorophenyl)-N'-(6-cyano-2-benzothiazolyl)- Chemical Properties,Uses,Production
Biological Activity
HB007 is a small ubiquitin-related modifier 1 (SUMO1) degrader. HB007 induces ubiquitination and degradation of SUMO1, resulting in reduced tumor growth in vivo. HB007 can be used for the research of brain, breast, colon, and lung cancers[1][2]. HB007 (compound 24) (0.1-100 μM) inhibits LN229 cell growth in a concentration-dependent manner t[1].HB007 (10-25 μM) reduces SUM01 conjugation and total protein levels of SUM01 but not SUM02/3 or UB in LN229 cells t[1]. HB007 (compound 24) (25-50 mg/kg; i.p. for 15 d) significantly suppresses tumor growth of colon and lung cancer but had no effect on the body weights of mice[1].
References
[1]. Bellail AC, et, al. Ubiquitination and degradation of SUMO1 by small-molecule degraders extends survival of mice with patient-derived tumors. Sci Transl Med. 2021 Oct 13;13(615):eabh1486. [2]. BELLAIL A, et, al. Compositions and methods for treating cancer. WO2019217509A1.
Urea, N-(3-chlorophenyl)-N'-(6-cyano-2-benzothiazolyl)- Preparation Products And Raw materials
Raw materials
Preparation Products
Urea, N-(3-chlorophenyl)-N'-(6-cyano-2-benzothiazolyl)- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd. | 21-57721279 | sales@shydchem.com.cn | China | 982 | 56 |
| DC Chemicals | 021-58447131 13564518121 | sales@dcchemicals.com | China | 9412 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24017 | 58 |
| Shanghai?Medlife?Pharm-Tech?Co.,?Ltd | 021-59167510 18117107507 | vip@med-life.cn | China | 5014 | 58 |
| Supplier | Advantage |
|---|---|
| Aladdin Scientific | 58 |
| Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd. | 56 |
| DC Chemicals | 58 |
| TargetMol Chemicals Inc. | 58 |
| Shanghai?Medlife?Pharm-Tech?Co.,?Ltd | 58 |