4-Morpholineethanesulfonic acid
- CAS No.
- 4432-31-9
- Chemical Name:
- 4-Morpholineethanesulfonic acid
- Synonyms
- MES;2-(N-MORPHOLINO)ETHANESULFONIC ACID;2-MORPHOLINOETHANESULFONIC ACID;MES 2-Morpholinoethanesulfonic acid;ME1;TIMTEC-BB;2-(N-Morpholino)ethanesulfonic;4-MORPHOLINOETHANESULFONIC ACID;MKS1;BBS13
- CBNumber:
- CB3100297
- Molecular Formula:
- C6H13NO4S
- Molecular Weight:
- 195.24
- MDL Number:
- MFCD00006181
- MOL File:
- 4432-31-9.mol
- MSDS File:
- SDS
| Melting point | >300 °C(lit.) |
|---|---|
| Boiling point | 102°C |
| Density | 1.208 (estimate) |
| refractive index | 1.5500 (estimate) |
| storage temp. | 2-8°C |
| solubility | H2O: 0.5 M at 20 °C, clear |
| pka | pKa at 0.1M ionic: 0°, 6.38; 20°, 6.15; 37°, 5.98; pKa1 1.99; pKa2 6.21; pKa/°C -0.011 |
| form | Powder |
| color | White |
| PH | 2.5-4.0 (25℃ in neat) |
| PH Range | 5.5 - 6.7 |
| Water Solubility | 185.2g/L at 20℃ |
| λmax |
λ: 260 nm Amax: 0.01 λ: 280 nm Amax: 0.01 |
| Merck | 13,5929 |
| BRN | 6350956 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| InChIKey | SXGZJKUKBWWHRA-UHFFFAOYSA-N |
| LogP | -2.2 at 20℃ |
| CAS DataBase Reference | 4432-31-9(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 2GNK67Q0C4 |
| EPA Substance Registry System | 4-Morpholineethanesulfonic acid (4432-31-9) |
| UNSPSC Code | 12161704 |
| NACRES | NA.25 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P271-P280 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36-24/25-22 |
| WGK Germany | 1 |
| RTECS | QE9104530 |
| HS Code | 29349990 |
4-Morpholineethanesulfonic acid price More Price(40)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 76039 | MES solution BioUltra, for molecular biology, 0.5?M in H2O | 4432-31-9 | 100ML | $206 | 2024-03-01 | Buy |
| Sigma-Aldrich | 475893 | MES, Free Acid, ULTROL® Grade A zwitterionic buffer useful in the pH range of 5.5-6.5. Has a pKa of 6.10 at 25°C. Absorbance (1.0 M, H2O, 260 nm):0.05. | 4432-31-9 | 100G | $115 | 2024-03-01 | Buy |
| Sigma-Aldrich | 76039 | MES solution BioUltra, for molecular biology, 0.5?M in H2O | 4432-31-9 | 500ML | $818 | 2024-03-01 | Buy |
| Sigma-Aldrich | 475893 | MES, Free Acid, ULTROL® Grade A zwitterionic buffer useful in the pH range of 5.5-6.5. Has a pKa of 6.10 at 25°C. Absorbance (1.0 M, H2O, 260 nm):0.05. | 4432-31-9 | 500G | $561 | 2024-03-01 | Buy |
| Sigma-Aldrich | 475893 | MES, Free Acid, ULTROL® Grade A zwitterionic buffer useful in the pH range of 5.5-6.5. Has a pKa of 6.10 at 25°C. Absorbance (1.0 M, H2O, 260 nm):0.05. | 4432-31-9 | 1KG | $787 | 2024-03-01 | Buy |
4-Morpholineethanesulfonic acid Chemical Properties,Uses,Production
Application
4-Morpholineethanesulfonic acid (MES) is one of the good′s buffers, and the most extensively application is biological buffers. MES is a zwitterionic N-substituted aminosulfonic acid with a morpholinic ring and it does not form complexes with the majority of the metals used in environmental and biological studies. It is easily soluble in water and has minimum lipid solubility, making it impermeable to membranes. MES has been also used as a component of the elution buffer used to elute plasma from α2-macroglobulin affinity column. It has been used as an activation buffer during antibody conjugation to microparticles and it has been used in the functionalization of microchannels during the creation of microfluidic-integrated surface plasmon resonance (SPR) platform for pathogen detection.
Chemical Properties
White/clear crystalline powder
Uses
MES solution has been used to activate microspheres. It has also been used as a component of activating solution to activate carboxyl groups of poly lactic-co-glycolic acid (PLGA).
Uses
Biological buffer.
Definition
ChEBI: 2-(N-morpholino)ethanesulfonic acid is a Good's buffer substance, pKa = 6.15 at 20 ℃. It is an organosulfonic acid and a MES. It is a conjugate acid of a 2-(N-morpholino)ethanesulfonate. It is a tautomer of a 2-(N-morpholiniumyl)ethanesulfonate.
General Description
MES is one of the Good′s buffers, the most extensively used biological buffers. MES is a zwitterionic N-substituted aminosulfonic acid with a morpholinic ring. It does not form complexes with majority of the metals used in environmental and biological studies. It is easily soluble in water and has minimum lipid solubility, making it impermeable to membranes.
Flammability and Explosibility
Not classified
storage
Store at RT
Purification Methods
Crystallise MES from hot EtOH containing a little water. The picrate crystallises from EtOH and has m 178.8-182o. [Malkiel & Mason J Org Chem 8 199 1943, Beilstein 27 III/IV 370.]
4-Morpholineethanesulfonic acid Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Tangshan Moneide Trading Co., Ltd. | +86-315-8309571 +8615633399667 | sales@moneidechem.com | China | 574 | 58 |
| Jiangsu Boquan Biotechnology Co., Ltd. | +86-18168774353 | boquanshengwu003@boquansw.com | China | 248 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531153977 | allison@yan-xi.com | China | 5854 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5868 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18137 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20235 | 58 |
| Apeloa production Co.,Limited | +8619933239880 | admin@apcl.com.cn | China | 861 | 58 |
| Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 | admin@zlchemi.com | China | 3692 | 58 |
| HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | +8615350851019 | admin@86-ss.com | China | 1001 | 58 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-+86-371-66670886 | info@dakenam.com | China | 19809 | 58 |
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View Lastest Price from 4-Morpholineethanesulfonic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-24 | 4-Morpholineethanesulfonic acid
4432-31-9
|
US $4.00 / kg | 1kg | 99% | 200mt | Jinan Finer Chemical Co., Ltd | |
 |
2025-04-24 | 4-Morpholineethanesulfonic acid
4432-31-9
|
US $0.00 / KG | 1KG | 99% | 3500kg/month | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2025-04-23 | 4-Morpholineethanesulfonic acid
4432-31-9
|
US $100.00-75.00 / kg | 1kg | 99% | 5000 | HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD |
-
- 4-Morpholineethanesulfonic acid
4432-31-9
- US $4.00 / kg
- 99%
- Jinan Finer Chemical Co., Ltd
-
- 4-Morpholineethanesulfonic acid
4432-31-9
- US $0.00 / KG
- 99%
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- 4-Morpholineethanesulfonic acid
4432-31-9
- US $100.00-75.00 / kg
- 99%
- HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
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