ChemicalBook >> CAS DataBase List >>1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 9-(3-aminopropoxy)-4,11-diethyl-4-hydroxy-, hydrochloride (1:1), (4S)-

1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 9-(3-aminopropoxy)-4,11-diethyl-4-hydroxy-, hydrochloride (1:1), (4S)-

1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 9-(3-aminopropoxy)-4,11-diethyl-4-hydroxy-, hydrochloride (1:1), (4S)- structure

CAS No.: 187793-52-8

Chemical Name:: 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 9-(3-aminopropoxy)-4,11-diethyl-4-hydroxy-, hydrochloride (1:1), (4S)-

Synonyms: T-2513 hydrochloride;1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 9-(3-aminopropoxy)-4,11-diethyl-4-hydroxy-, hydrochloride (1:1), (4S)-

CBNumber:: CB311028711

Molecular Formula:: C25H28ClN3O5

Molecular Weight:: 485.97

MDL Number:

MOL File:: 187793-52-8.mol

Last updated:2025-04-18 09:51:59

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1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 9-(3-aminopropoxy)-4,11-diethyl-4-hydroxy-, hydrochloride (1:1), (4S)- Chemical Properties,Uses,Production

Uses

T-2513 hydrochloride is a selective topoisomerase I inhibitor. T-2513 hydrochloride binds covalently to and stabilizes the topoisomerase I-DNA complex and inhibits DNA replication and RNA synthesis, ultimately leading to cell death[1].

in vivo

T-2513 hydrochloride (1-100 mg/kg) shows Antitumor Activity against Walker-256 carcinoma^[2].

Animal Model:	Rats bearing Walker-256 carcinoma^[2]
Dosage:	1, 10, and 100 mg/kg
Administration:
Result:	The ED₅₀ was 23 mg/kg.

IC 50

Topoisomerase I

References

[1] Stephan A Veltkamp, et al. Clinical and pharmacologic study of the novel prodrug delimotecan (MEN 4901/T-0128) in patients with solid tumors. Clin Cancer Res. 2008 Nov 15;14(22):7535-44. DOI:10.1158/1078-0432.CCR-08-0438
[2] S Okuno, et al. Complete regression of xenografted human carcinomas by camptothecin analogue-carboxymethyl dextran conjugate (T-0128). Cancer Res. 2000 Jun 1;60(11):2988-95. PMID:10850447

1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 9-(3-aminopropoxy)-4,11-diethyl-4-hydroxy-, hydrochloride (1:1), (4S)- Preparation Products And Raw materials

Raw materials

Preparation Products

1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 9-(3-aminopropoxy)-4,11-diethyl-4-hydroxy-, hydrochloride (1:1), (4S)- Suppliers

Global( 1)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	19820	58

Supplier	Advantage
TargetMol Chemicals Inc.	58

1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 9-(3-aminopropoxy)-4,11-diethyl-4-hydroxy-, hydrochloride (1:1), (4S)- T-2513 hydrochloride 187793-52-8