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4-Aminopyrazolo[3,4-d]pyrimidine

4-Aminopyrazolo[3,4-d]pyrimidine structure

CAS No.: 2380-63-4

Chemical Name:: 4-Aminopyrazolo[3,4-d]pyrimidine

Synonyms: 1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE;4-app;4 APP;nsc1393;NSC 1393;4-Aminopyra;Aminopurinol;Pyrazoloadenine;TIMTEC-BB SBB004205;ADENINE ANTIMETABOLITE

CBNumber:: CB3112436

Molecular Formula:: C5H5N5

Molecular Weight:: 135.13

MDL Number:: MFCD00005688

MOL File:: 2380-63-4.mol

Last updated:2024-12-18 14:08:57

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4-Aminopyrazolo[3,4-d]pyrimidine Properties

Melting point	>325 °C(lit.)
Boiling point	238.81°C (rough estimate)
Density	1.3795 (rough estimate)
refractive index	1.7000 (estimate)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	soluble in DMSO
form	powder to crystal
pka	12.12±0.20(Predicted)
color	White to Orange to Green
Water Solubility	Insoluble in water.
BRN	5824
InChIKey	LHCPRYRLDOSKHK-UHFFFAOYSA-N
CAS DataBase Reference	2380-63-4(CAS DataBase Reference)
FDA UNII	0356MAT9LX
NIST Chemistry Reference	1H-pyrazolo[3,4-d]pyrimidin-4-amine(2380-63-4)
EPA Substance Registry System	1H-Pyrazolo[3,4-d]pyrimidin-4-amine (2380-63-4)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06,GHS07

Signal word

Danger

Hazard statements

H301-H315-H319-H335

Precautionary statements

P264-P270-P280-P301+P310+P330-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P405-P501-P301+P310a-P321-P501a-P261-P301+P310-P305+P351+P338

Hazard Codes

Risk Statements

25-36/37/38-23/24/25

Safety Statements

26-36/37/39-45-22-36

RIDADR

UN 2811 6.1/PG 3

WGK Germany

RTECS

UR0717000

TSCA

Yes

HazardClass

6.1

PackingGroup

III

HS Code

29335990

Toxicity

LD50 oral in rat: 141mg/kg

NFPA 704

	0
3		0

4-Aminopyrazolo[3,4-d]pyrimidine price More Price(32)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	A1041	4-Aminopyrazolo[3,4-d]pyrimidine >97.0%(HPLC)(T)	2380-63-4	100mg	$33	2024-03-01	Buy
TCI Chemical	A1041	4-Aminopyrazolo[3,4-d]pyrimidine	2380-63-4	1G	$44	2024-03-01	Buy
TCI Chemical	A1041	4-Aminopyrazolo[3,4-d]pyrimidine	2380-63-4	5G	$132	2024-03-01	Buy
Alfa Aesar	L03519	4-Amino-1H-pyrazolo[3,4-d]pyrimidine, 98%	2380-63-4	5g	$253.05	2023-01-06	Buy
Alfa Aesar	L03519	4-Amino-1H-pyrazolo[3,4-d]pyrimidine, 98%	2380-63-4	250mg	$23	2021-12-16	Buy

Product number	Packaging	Price	Buy
A1041	100mg	$33	Buy
A1041	1G	$44	Buy
A1041	5G	$132	Buy
L03519	5g	$253.05	Buy
L03519	250mg	$23	Buy

4-Aminopyrazolo[3,4-d]pyrimidine Chemical Properties,Uses,Production

Description

4-aminopyrazolo[3,4-d]pyrimidine (4-APP), the isomer of adenine with the five-membered ring in the pyrazole configuration, is by far the most potent inhibitor of both enzymatic reactions catalyzed by Stx1. It is also a new type of mTOR inhibitor. The 4-aminopyrazolo[3,4-d]pyrimidines, a well-characterized class of compounds for tyrosine kinase inhibition, were used as a Src inhibitor module that blocks the adenosine binding site[1-2].

Chemical Properties

Light Tan Solid

Uses

4-Amino-1H-pyrazolo[3,4-d]pyrimidine decreases serum cholesterol markedly in rats.

References

[1] M Brigotti. “4-Aminopyrazolo[3,4-d]pyrimidine (4-APP) as a novel inhibitor of the RNA and DNA depurination induced by Shiga toxin 1.” Nucleic Acids Research 28 12 (2000): 2383–8.
[2] Ho Jin Lee. “Development of a 4-aminopyrazolo[3,4-d]pyrimidine-based dual IGF1R/Src inhibitor as a novel anticancer agent with minimal toxicity.” Molecular Cancer 17 1 (2018): 50.

4-Aminopyrazolo[3,4-d]pyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

(3R)-1-Boc-3-(4-aMino-3-iodo-1H-pyrazolo[3,4-d]pyriMidin-1-yl)piperidine

4-Aminopyrazolo[3,4-d]pyrimidine Suppliers

Global( 421)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Changzhou uniringchem Co., Ltd.	+undefined13585446801	sales@uniringchem.com	China	68	58
Taizhou Creating Bio-pharm co., ltd.	+8613586099526	post@creatingbiopharm.com	China	217	58
Hebei Weibang Biotechnology Co., Ltd	+8615531157085	abby@weibangbio.com	China	8810	58
Hebei Mojin Biotechnology Co., Ltd	+86 13288715578 +8613288715578	sales@hbmojin.com	China	12834	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20284	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29791	60
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1803	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21634	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32957	60
Anqing Chico Pharmaceutical Co., Ltd.	15380796838	chloewu@chicopharm.cn	CHINA	340	58

Supplier	Advantage
Changzhou uniringchem Co., Ltd.	58
Taizhou Creating Bio-pharm co., ltd.	58
Hebei Weibang Biotechnology Co., Ltd	58
Hebei Mojin Biotechnology Co., Ltd	58
Henan Fengda Chemical Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
Anqing Chico Pharmaceutical Co., Ltd.	58

View Lastest Price from 4-Aminopyrazolo[3,4-d]pyrimidine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-12-20	4-Aminopyrazolo[3,4-d]pyrimidine 2380-63-4	US $0.00 / kg	1kg	98%	20TON	Hubei Lidu New Material Technology Co., Ltd
2024-11-26	4-Aminopyrazolo[3,4-d]pyrimidine 2380-63-4	US $0.00-0.00 / kg	1kg	98%	1 ton	Nanjing Fred Technology Co., Ltd
2024-11-19	Pyrazoloadenine 2380-63-4	US $29.00 / g		99.10%	10g	TargetMol Chemicals Inc.

4-Aminopyrazolo[3,4-d]pyrimidine
2380-63-4
US $0.00 / kg
98%
Hubei Lidu New Material Technology Co., Ltd

4-Aminopyrazolo[3,4-d]pyrimidine
2380-63-4
US $0.00-0.00 / kg
98%
Nanjing Fred Technology Co., Ltd

Pyrazoloadenine
2380-63-4
US $29.00 / g
99.10%
TargetMol Chemicals Inc.

4-Aminopyrazolo[3,4-d]pyrimidine Spectrum

4-Aminopyrazolo[3,4-d]pyrimidine(2380-63-4)¹HNMR 4-Aminopyrazolo[3,4-d]pyrimidine(2380-63-4)Raman 4-Aminopyrazolo[3,4-d]pyrimidine(2380-63-4)IR

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1of4

TIMTEC-BB SBB004205 1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE 4-AMINOPYRAZOLO[3,4-D]PYRIMIDINE 4-AMINO-1H-PYRAZOLO[3,4-D]PYRIMIDINE ADENINE ANTIMETABOLITE 4- aMinopyrazolo [3,4-d] pyriMidines PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE 4-Amino-1H-pyrazolo[3,4-d]pyrimidine,98% 1(H)-4-amine-pyrazolo[3,4-d]pyrimidine 1H-Pyrazolo[3,4-d]pyrimidine-4-ylamine 4-Aminopyrazolo[3,4-d]pyrimidine 98% 1H-pyrazolo[4,3-e]pyrimidin-4-amine 1H-pyrazolo[4,3-e]pyrimidin-4-ylamine 4-Aminopyrazolo[3,4-d]pyrimidine 4-Aminopyra 1H-Pyrazolo[3,4-d]pyrimidine, 4-amino- 4 APP 4-Aminopyrazole(3,4-d)pyrimidine 4-Aminopyrazolopyrimidine 4-d)pyrimidine,4-amino-1h-pyrazolo( NSC 1393 nsc1393 Pyrazoloadenine 1H-Pyrazolo[3,4-d]pyrimidin-4-amine (9CI) Adenine antimetabolite, Pyrazolo[3,4-d]pyrimidin-4-amin Aminopurinol 4-Amino-1,2,5,7-tetraaza-1H-indene 4-Aminopyrazolo[3,4-d]pyrimidine,98% 4-AMinopyrazolo[3,4-d]pyriMidine, 97.5% Pyrazolo[3,4-d]pyrimidin-4-amin 4-Aminopyrazolo[3,4-d]pyrimidine > 4-Dihydroxybenzylamine hydrobromide 1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE 4-app 1H-Pyrazolo[3,4-d]pyrimidin-4-amine (9CI, ACI) 4-aminopyrazole and [3,4-d] pyrimidine IbrutinibIntermediate5 2380-63-4 Building Blocks Heterocyclic Building Blocks Pyrimidines Heterocyclic Compounds Heterocycles PYRIMIDINE Pyridines, Pyrimidines, Purines and Pteredines Heterocycle-Pyrimidine series