Benazepril hydrochloride

Benazepril hydrochloride Properties

Melting point	188-190°C
alpha	D -141.0° (c = 0.9 in ethanol)
storage temp.	2-8°C
solubility	DMSO: ~34 mg/mL, soluble
form	solid
color	white
Merck	14,1031
InChIKey	VPSRQEHTHIMDQM-FKLPMGAJSA-N
SMILES	C12=CC=CC=C1CC[C@H](N[C@H](C(=O)OCC)CCC1C=CC=CC=1)C(=O)N2CC(=O)O.Cl \|&1:8,10,r\|
CAS DataBase Reference	86541-74-4(CAS DataBase Reference)
FDA UNII	N1SN99T69T
NCI Drug Dictionary	benazepril hydrochloride

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS08
Signal word	Warning
Hazard statements	H361fd
Precautionary statements	P201-P202-P280-P308+P313-P405-P501
Safety Statements	22-24/25
RIDADR	3077
WGK Germany	2
RTECS	CX7065000
HS Code	29337900

Benazepril hydrochloride price More Price(51)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	B0935	Benazepril hydrochloride ≥98% (HPLC), solid	86541-74-4	250mg	$795	2024-03-01	Buy
Sigma-Aldrich	1048619	Benazepril hydrochloride United States Pharmacopeia (USP) Reference Standard	86541-74-4	125mg	$436	2024-03-01	Buy
TCI Chemical	B3611	Benazepril Hydrochloride >98.0%(HPLC)(T)	86541-74-4	1g	$240	2024-03-01	Buy
TCI Chemical	B3611	Benazepril Hydrochloride >98.0%(HPLC)(T)	86541-74-4	5g	$528	2024-03-01	Buy
Cayman Chemical	23804	Benazepril (hydrochloride) ≥98%	86541-74-4	50mg	$57	2024-03-01	Buy

Product number	Packaging	Price	Buy
B0935	250mg	$795	Buy
1048619	125mg	$436	Buy
B3611	1g	$240	Buy
B3611	5g	$528	Buy
23804	50mg	$57	Buy

Benazepril hydrochloride Chemical Properties,Uses,Production

Description

Benazepril hydrochloride is a long-acting and effective angiotensin-converting enzyme (ACE) inhibitor used to treat essential hypertension. It is the hydrochloride salt form of benazepril, which is a prodrug of benazeprilat. After hepatic cleavage of the ester group, benazepril is converted to benazeprilat. In healthy humans, it was well tolerated and showed no phmacokinetic interactions with furosemide, hydrochlorothiazide, chlorthalidone, digoxin, cimetidine, atenolol, or naproxen.

Chemical Properties

This substance is a white to off-white crystalline powder. It is highly soluble in water, ethanol, and methanol with a solubility of over 100 mg/mL.

Originator

Ciba-Geigy (Switzerland)

Uses

Benazepril HCl is an angiotensin-converting enzyme (ACE) inhibitors that is commonly used as a sedative, hypnotic, and antihypertensive medication. Benazepril is used alone or together with other medicines to treat high blood pressure (hypertension). It works by reducing the levels of certain chemicals that cause blood vessels to constrict, allowing for smoother blood flow.

Definition

ChEBI: Benazepril hydrochloride is a hydrochloride salt resulting from the reaction of benazepril with 1 mol eq. of hydrogen chloride. It is used as a prodrug for angiotensin-converting enzyme inhibitor benazeprilat in the treatment of hypertension and heart failure. It has a role as an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor. It contains a benazepril(1+).

brand name

Lotensin (Novartis);Cibacen.

Therapeutic Function

Antihypertensive

General Description

Benazepril is a prodrug of the angiotensin converting enzyme (ACE) inhibitor benazeprilat . It is metabolized to benazeprilat by hepatic esterases. Benazepril inhibits the in vitro enzymatic activity of partially purified ACE isolated from rabbit lung (IC50 = 2 nM). It decreases the triglyceride and total cholesterol levels in normotensive rats when administered at a dose of 30 mg/kg and decreases aortic atherosclerosis in cholesterol-fed rabbits when administered at a dose of 3 mg/kg per day. Benazepril (0.1-10 mg/kg per day) reduces blood pressure in spontaneously hypertensive rats. It also decreases proteinuria in cats with chronic kidney disease when administered at doses ranging from 0.5 to 1 mg/kg per day. Formulations containing benazepril have been used to treat hypertension, congestive heart failure, and chronic kidney disease in both human and veterinary medicine.

Biological Activity

Non-peptide angiotensin-converting enzyme (ACE) inhibitor. Reduces blood pressure and myocardial hypertrophy in spontaneous hypertensive rats.

Synthesis

Benazepril hydrochloride is prepared through the following steps:
Step 1: Preparation of (R)-ethyl 2-hydroxy-4-phenylbutyrate using ethyl 2-oxo-4-phenylbutyrate as a raw material and cinchonidine as a chiral ligand through asymmetric catalytic hydrogenation under high pressure.
Step 2: The intermediate obtained from step 1 reacts with p-nitrobenzenesulfonyl chloride or trifluoromethanesulfonic anhydride to obtain the corresponding sulfonate.
Step 3: The sulfonate obtained from step 2 undergoes nucleophilic substitution and salt hydrolysis with (3S)-3-amino-2,3,4,5-tetrahydro-2-oxo-1H-benzazepine-1-tert-butyl acetate to obtain benazepril hydrochloride.
This procedure has been described in detail in documents such as CN110835319A, US4785089, WO02076375, EP206993, and CN105061312.

Mode of action

The mechanism of action of benazepril is to inhibit the activity of the angiotensin-converting enzyme, blocking the conversion of angiotensin I to angiotensin II Label, thereby alleviating a series of symptoms caused by angiotensin (elevated blood pressure, increased excitatory heart rate caused by vasodilation, insufficient cardiac output, etc.).

References

https://www.novartis.com/us-en/sites/novartis_us/files/lotrel.pdf
https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=a216253b-27cb-42ef-b5a8-67fb05aafb88
Extrapyramidal side effect of donepezil hydrochloride in an elderly patient DOI: 10.1097/MD.0000000000019443
Use of convertible isocyanides for the synthesis of benazepril hydrochloride DOI: 10.1007/s12039-021-01892-8

Benazepril hydrochloride Preparation Products And Raw materials

Raw materials

Sodium cyanoborohydride Ethyl 2-oxo-4-phenylbutyrate Sodium azide

Preparation Products

Benazepril

Benazepril hydrochloride Suppliers

Global( 430)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Weibang Biotechnology Co., Ltd	+8615531157085	abby@weibangbio.com	China	8808	58
Hebei Mojin Biotechnology Co., Ltd	+86 13288715578 +8613288715578	sales@hbmojin.com	China	12834	58
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	peter@yan-xi.com	China	5857	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-13131129325	sales1@chuanghaibio.com	China	5889	58
Changzhou Rokechem Technology Co., Ltd.	18758118018	sales001@rokechem.com	China	255	58
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1803	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21634	55
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3009	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29880	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58

Supplier	Advantage
Hebei Weibang Biotechnology Co., Ltd	58
Hebei Mojin Biotechnology Co., Ltd	58
Hebei Yanxi Chemical Co., Ltd.	58
Hebei Chuanghai Biotechnology Co,.LTD	58
Changzhou Rokechem Technology Co., Ltd.	58
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55
Nanjing ChemLin Chemical Industry Co., Ltd.	60
career henan chemical co	58
Hubei Jusheng Technology Co.,Ltd.	58

View Lastest Price from Benazepril hydrochloride manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-12-13	Benazepril hydrochloride 86541-74-4	US $0.00 / kg	1kg	98%-102%	500kg	WUHAN FORTUNA CHEMICAL CO., LTD
2024-11-28	Benazepril hydrochloride 86541-74-4	US $10.00 / KG	1KG	99%	10 mt	Hebei Weibang Biotechnology Co., Ltd
2024-11-19	Benazepril hydrochloride 86541-74-4	US $50.00 / mL		≥95%	10g	TargetMol Chemicals Inc.

Benazepril hydrochloride
86541-74-4
US $0.00 / kg
98%-102%
WUHAN FORTUNA CHEMICAL CO., LTD

Benazepril hydrochloride
86541-74-4
US $10.00 / KG
99%
Hebei Weibang Biotechnology Co., Ltd

Benazepril hydrochloride
86541-74-4
US $50.00 / mL
≥95%
TargetMol Chemicals Inc.

Benazepril hydrochloride Spectrum

Benazepril hydrochloride(86541-74-4)¹HNMR

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1h-1-benzazepine-1-aceticacid,2,3,4,5-tetrahydro-3-((1-(ethoxycarbonyl)-3-phe cgs14824a monohydrochloride,(s-(r*,r*))-nylpropyl)amino)-2-oxo BenazeprilHclC24H28N205.HC1 1H-1-Benzazepine-1-acetic acid, 3-(1S)-1-(ethoxycarbonyl)-3-phenylpropylamino-2,3,4,5-tetrahydro-2-oxo-, monohydrochloride, (3S)- 1H-1-Benzazepine-1-acetic acid, 3-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-, monohydrochloride, [S-(R*,R*)]- CGS 14824A HCl Lotension Benazenprilhydrochloride {(3S)-3-[(1S)-1-Ethoxycarbonyl-3-phenylpropylamino]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-1-yl}acetic acid hydrochloride Benazepril hydrochloride Benazepril hydrochloride (3S)-3-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic acid hydrochloride Benazepril Hydrochloride, SS-form 1H-1-Benzazepine-1-acetic acid, 2,3,4,5-tetrahydro-3-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-2-oxo-, monohydrochloride, (S-(R*,R*))- Cibace Cibacen chf Benazepril hydrochloride,(3S)-3-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic acid hydrochloride Benazepril Hydrochloride (125 mg) 2-((S)-3-((S)-1-ethoxy-1-oxo-4-phenylbutan-2-ylamino)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)aceticacidhydrochloride Benazepri hydrochloride Benazepril HCl API 1H-1-Benzazepine-1-acetic acid, 3-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]aMino]-2,3,4,5-tetrahydro-2-oxo-, hydrochloride (1:1), (3S)- 2-((S)-3-((S)-1-ethoxy-1-oxo-4-phenylbutan-2-ylamino)-2-oxo-2,3,4,5-tetrahydrobenzo[b]azepin-1-yl)acetic acid hydrochloride Benazepril hydrochloride Benazepril hydrochloride, 98.5%, an angiotensin-converting enzyme (ACE) inhibitor Benazepril Benazepril HCL yansuanbeinapuli 2-[(3S)-3-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]-2-oxo-4,5-dihydro-3H-1-benzazepin-1-yl]acetic acid hydrochloride Benazepril for system suitability CRS BenazeprilHydrochloride> Benazepril hydrochloride CRS Benazepril hydrochloride USP/EP/BP Benazepril HCl （CGS14824A) Benazepril HydrochlorideQ: What is Benazepril Hydrochloride Q: What is the CAS Number of Benazepril Hydrochloride Q: What is the storage condition of Benazepril Hydrochloride Q: What are the applications of Benazepril Hydrochloride Benazepril Hydrochloride (1048619) 3-Cresotic acid Lotensin Benazeprilhydrochloride/CGS14824A Benazepril HCl Reference Standard Benazepril HCI Belapril hydrochloride 86541-74-4 C24H28N2O5HClC24H29ClN2 C24H28N2O5ClH C24H28N2O5HClC24H29ClN2O5 C24H29ClN2O5 SONATA API Amines Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals 86541-74-4