(2S)-2-[[4-[(2-fluorophenyl)methoxy]phenyl]methylamino]propanamide
![(2S)-2-[[4-[(2-fluorophenyl)methoxy]phenyl]methylamino]propanamide Structure](CAS/GIF/133865-88-0.gif)
- CAS No.
- 133865-88-0
- Chemical Name:
- (2S)-2-[[4-[(2-fluorophenyl)methoxy]phenyl]methylamino]propanamide
- Synonyms
- ralfinamide;Priralfinamide;Nw-1029;FCE-26742A;Ralfinamida;Safinamide-6;Unii-3lpf0S0gvv;Ralfinamide [inn];Guadecitabine Sodium;2- Fluoro Safinamide
- CBNumber:
- CB31260820
- Molecular Formula:
- C17H19FN2O2
- Molecular Weight:
- 302.34
- MDL Number:
- MFCD08272558
- MOL File:
- 133865-88-0.mol
- MSDS File:
- SDS
| Boiling point | 479.0±40.0 °C(Predicted) |
|---|---|
| Density | 1.189 |
| storage temp. | 2-8°C(protect from light) |
| solubility | DMSO: ≥ 125 mg/mL (413.44 mM) |
| pka | 16.03±0.50(Predicted) |
| form | Solid |
| color | White to off-white |
| FDA UNII | 3LPF0S0GVV |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
(2S)-2-[[4-[(2-fluorophenyl)methoxy]phenyl]methylamino]propanamide price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0021330 | Ralfinamide 99.78% | 133865-88-0 | 10mg | $90 | 2021-12-16 | Buy |
| ChemScene | CS-0021330 | Ralfinamide 99.78% | 133865-88-0 | 50mg | $360 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0008093 | RALFINAMIDE 95.00% | 133865-88-0 | 5MG | $497.39 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0008093 | RALFINAMIDE 95.00% | 133865-88-0 | 1G | $945 | 2021-12-16 | Buy |
| AK Scientific | 6134AA | (S)-2-((4-((2-Fluorobenzyl)oxy)benzyl)amino)propanamide | 133865-88-0 | 5g | $1242 | 2021-12-16 | Buy |
(2S)-2-[[4-[(2-fluorophenyl)methoxy]phenyl]methylamino]propanamide Chemical Properties,Uses,Production
Uses
Ralfinamide (FCE-26742A) is an orally available Na+ blocker derived from α-aminoamide, with function of suppressing pain[1][2].
Biological Activity
Ralfinamide (FCE-26742A) is an orally available sodium channel blocker derived from α-aminoamide with analgesic properties.
in vivo
Ralfinamide (30 mg/kg, 60 mg/kg; p.o.; twice daily; 42 days) treated with Ralfinamide (80 mg/kg; p.o.; twice daily; 7 days) preoperatively suppresses neuropathic pain[1].
| Animal Model: | 81 adult male Sprague–Dawley male rats (260–460 g)[1] |
| Dosage: | 80 mg/kg (7 days preoperatively), 30 mg/kg, 60 mg/kg (postoperative) |
| Administration: | Oral gavage; twice daily; until postoperative day 42 |
| Result: | Suppressed neuropathic pain. |
References
[1] Zhang SH, et al. Ralfinamide administered orally before hindpaw neurectomy or postoperatively provided long-lasting suppression of spontaneous neuropathic pain-related behavior in the rat. Pain. 2008 Oct 15;139(2):293-305. DOI:10.1016/j.pain.2008.04.020
[2] Liang X, et al. Effects of ralfinamide in models of nerve injury and chemotherapy-induced neuropathic pain. Eur J Pharmacol. 2018 Mar 15;823:27-34. DOI:10.1016/j.ejphar.2018.01.041
(2S)-2-[[4-[(2-fluorophenyl)methoxy]phenyl]methylamino]propanamide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14332 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49732 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29808 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| Hangzhou Huarong Pharm Co., Ltd. | 571-86758373 +8613588754946 | sales@huarongpharm.com | CHINA | 3148 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38630 | 58 | |
| China National Standard Pharmaceutical Corporation Limited | +8615391658522 | overseasales@yongstandards.com | China | 11922 | 58 |
View Lastest Price from (2S)-2-[[4-[(2-fluorophenyl)methoxy]phenyl]methylamino]propanamide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | Ralfinamide
133865-88-0
|
US $43.00-165.00 / mg | 99.41% | 10g | TargetMol Chemicals Inc. | ||
![(2S)-2-[[4-[(2-fluorophenyl)methoxy]phenyl]methylamino]propanamide pictures](https://img.chemicalbook.com/ProductImageEN/2020-1/Small/57c1d18e-f7bb-43ac-b7f8-1bcb800f08b7.png) |
2020-01-03 | (2S)-2-[[4-[(2-fluorophenyl)methoxy]phenyl]methylamino]propanamide
133865-88-0
|
US $1.00 / KG | 1KG | 95-99% | 1ton | Career Henan Chemical Co |
-
- Ralfinamide
133865-88-0
- US $43.00-165.00 / mg
- 99.41%
- TargetMol Chemicals Inc.
-
- (2S)-2-[[4-[(2-fluorophenyl)methoxy]phenyl]methylamino]propanamide
133865-88-0
- US $1.00 / KG
- 95-99%
- Career Henan Chemical Co
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