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Tamsulosin

Tamsulosin structure

CAS No.: 106133-20-4

Chemical Name:: Tamsulosin

Synonyms: TAMSULOSINE;Tamsulosin Base;TAMSOLUSIN;Tamsulosin USP/EP/BP;Amsulosin;TAMSULOSIN;TANSULOSIN;TaMsulosin USP;TamsulosinRHCl;Tamsulosin 106133-20-4

CBNumber:: CB3128875

Molecular Formula:: C20H28N2O5S

Molecular Weight:: 408.51

MDL Number:: MFCD00871531

MOL File:: 106133-20-4.mol

Last updated:2024-07-02 08:55:04

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Tamsulosin Properties

Melting point	226-228°C
Boiling point	595.5±60.0 °C(Predicted)
Density	1.191±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	DMSO: 100 mg/mL (244.79 mM)
form	Solid
pka	10.08±0.60(Predicted)
color	White to off-white
CAS DataBase Reference	106133-20-4(CAS DataBase Reference)
FDA UNII	G3P28OML5I
ATC code	G04CA02

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P280-P301+P312-P302+P352-P305+P351+P338

Tamsulosin price More Price(17)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-2896	Tamsulosin 99.62%	106133-20-4	10mg	$60	2021-12-16	Buy
ChemScene	CS-2896	Tamsulosin 99.62%	106133-20-4	50mg	$120	2021-12-16	Buy
ChemScene	CS-2896	Tamsulosin 99.62%	106133-20-4	100mg	$180	2021-12-16	Buy
American Custom Chemicals Corporation	API0010078	TAMSULOSIN 95.00%	106133-20-4	1G	$374.85	2021-12-16	Buy
Matrix Scientific	093796	(R)-5-(2-((2-(2-Ethoxyphenoxy)ethyl)amino)-propyl)-2-methoxybenzenesulfonamide 95+%	106133-20-4	250mg	$530	2021-12-16	Buy

Product number	Packaging	Price	Buy
CS-2896	10mg	$60	Buy
CS-2896	50mg	$120	Buy
CS-2896	100mg	$180	Buy
API0010078	1G	$374.85	Buy
093796	250mg	$530	Buy

Tamsulosin Chemical Properties,Uses,Production

Description

Tamsulosin hydrochloride is the first in the class of potent and selective α- 1A adrenoceptor antagonists introduced for the treatment of dysuria associated with benign prostatic hypertrophy (BPH). In a clinical study, significant improvement in irritative and obstructive symptoms has been reported for tamsulosin treated patients with BPH. ln vitro studies in human penile erectile tissue and vas deferens indicated that tamsulosin may be of use in treating male sexual dysfunction.

Originator

Yamanouchi (Japan)

Uses

chemotherapy drug

Uses

tamsulosin

Definition

ChEBI: Tamsulosin is a 5-(2-{[2-(2-ethoxyphenoxy)ethyl]amino}propyl)-2-methoxybenzenesulfonamide that has (R)-configuration. A specific alpha1 adrenoceptor antagonist used (generally as its hydrochloride salt, tamsulosin hydrochloride) in the treatment of prostatic hyperplasia, chronic prostatitis, urinary retention, and help with the passage of kidney stones. It has a role as an alpha-adrenergic antagonist and an antineoplastic agent. It is a conjugate base of a tamsulosin(1+). It is an enantiomer of an ent-tamsulosin.

Manufacturing Process

In 1,000 ml of acetonitrile was suspended 17 g of 5-{2-[2-(2- ethoxyphenoxy)ethylamino]-1-hydroxy-2-methylethyl}-2- methoxybenzenesulfonamide hydrochloride and while stirring the suspension, 9 g of thionyl chloride was added dropwise to the suspension at room temperature, whereby the product first dissolved and then began to crystallize gradually. After stirring the mixture for two days, the crystals formed were recovered by filtration, washed with chloroform and dried to provide 15 g of 5-{1-chloro-2-[2-(2-ethoxyphenoxy)ethylamino]-2-methylethyl}-2- methoxybenzenesulfonamide hydrochloride. Melting point: 197°-200°C.
In methanol was dissolved the 5-{1-chloro-2-[2-(2- ethoxyphenoxy)ethylamino]ethyl}-2-methoxybenzenesulfonamide hydrochloride and after adding thereto 10% palladium carbon, dechlorination was performed under hydrogen stream at normal temperature and pressure. The palladium carbon was filtered away and the filtrate was concentrated under reduced pressure to provide the 2-methoxy-5-{2-[2-(2- ethoxyphenoxy)ethylamino]ethyl}benzenesulfonamide hydrochloride, which was recrystallized from 120 ml of a mixture of methanol and ethanol (1:4 by volume ratio) to provide the colorless crystals thereof. The melting point of the 5-{2-[2-(2-ethoxyphenoxy)ethylamino]-2-methylethyl}-2- methoxybenzenesulfonamide hydrochloride: 254°-256°C.

brand name

Harnal

Therapeutic Function

Antihypertensive

General Description

Tamsulosin (Flomax), a nonquinazoline benzensulfonamide,is the first in the class of subtype selective 1Ablocker.It is many folds more selective for α1A-receptorsthan for the other α1-receptors. This selectivity may favorblockade of α1A-receptors found in the prostate gland overthose found in vascular tissue. Tamsulosin is efficacious inthe treatment of BPH with little effect on blood pressure.Orthostatic hypotension is not as great with this agent aswith the nonselective quinazolines.

Tamsulosin synthesis

Synthesis of Tamsulosin from 2-(2-Ethoxyphenoxy)ethyl Methanesulfonate and R-(-)-5-(2-Amino-propyl)-2-methoxy-benzenesulfonamide

Tamsulosin Preparation Products And Raw materials

Raw materials

Hydrogen Palladium hydroxide Thionyl chloride 2-(2-ethoxyphenoxy)-N-[(2R)-1-(4-methoxy-3-sulfamoylphenyl)propan-2-yl]acetamide 2-(2-Ethoxyphenoxy)ethyl Methanesulfonate

5-(2-Aminopropyl)-2-methoxybenzenesulfonamide R-(-)-5-(2-Amino-propyl)-2-methoxy-benzenesulfonamide

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Preparation Products

Tamsulosin hydrochloride

Tamsulosin Suppliers

Global( 237)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Wuhan Fortuna Chemical Co., Ltd	+86-027-59207850	info@fortunachem.com	China	5978	58
Hebei Dangtong Import and export Co LTD	+86-13910575315 +86-13910575315	admin@hbdangtong.com	China	1000	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29791	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21634	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29882	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
Xiamen AmoyChem Co., Ltd	+86-86-5926051114 +8618959220845	sales@amoychem.com	China	6383	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39894	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49374	58

Supplier	Advantage
Wuhan Fortuna Chemical Co., Ltd	58
Hebei Dangtong Import and export Co LTD	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
Hubei Jusheng Technology Co.,Ltd.	58
Xiamen AmoyChem Co., Ltd	58
Chongqing Chemdad Co., Ltd	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58

View Lastest Price from Tamsulosin manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-11-22	Tamsulosin 106133-20-4	US $0.00 / KG	1KG	99%,USP	500kg/month	WUHAN FORTUNA CHEMICAL CO., LTD
2024-10-24	Tamsulosin 106133-20-4	US $50.00-30.00 / kg	1kg	99%	20Tons	Hebei Dangtong Import and export Co LTD
2023-11-01	Tamsulosin 106133-20-4	US $0.00-0.00 / kg	0.1kg	99.0%min	2000kg	Hangzhou ICH Biofarm Co., Ltd

Tamsulosin
106133-20-4
US $0.00 / KG
99%,USP
WUHAN FORTUNA CHEMICAL CO., LTD

Tamsulosin
106133-20-4
US $50.00-30.00 / kg
99%
Hebei Dangtong Import and export Co LTD

Tamsulosin
106133-20-4
US $0.00-0.00 / kg
99.0%min
Hangzhou ICH Biofarm Co., Ltd

Tamsulosin Spectrum

Tamsulosin(106133-20-4)¹HNMR

106133-20-4(Tamsulosin)Related Search:

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TAMSULOSIN, HYDROCHLORIDE 99.5%,TAMSULOSIN HCL,(R)-Tamsulosin Hydrochloride,Tamsulosin hydrochloride,rac Tamsulosin Hydrochloride 5-((2R)-2-AMINOPROPYL)-2-METHOXYBENZENESULFONAMIDE (INTERMEDIATE OF TAMSULOSIN) 5-(2-Aminopropyl)-2-methoxybenzenesulfonamide dl-Tamsulosin hydrochloride,Tamsulosin hydrochloride Ethylamine

Benzenesulfonamide CHEMBRDG-BB 9071974 (R)-(+)-5-(2-AMINOPROPYL)-2-METHOXYBENZENE SULFONAMIDE HYDROCHLORIDE

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5-[2-[2-(2-ethoxyphenoxy)ethylamino]propyl]-2-methoxy-benzenesulfonamide TAMSULOSIN (R)(-)5-[2-[2-(2-Ethoxyphenoxy)ethyl]amino-propyl]-2-methoxybenzenesulfonmidehydrochloride TamsulosinRHCl TANSULOSIN Amsulosin Benzenesulfonamide, 5-[(2R)-2-[[2-(2-ethoxyphenoxy)ethyl]amino]propyl]-2-methoxy- (9CI) Benzenesulfonamide, 5-[2-[[2-(2-ethoxyphenoxy)ethyl]amino]propyl]-2-methoxy-, (R)- (R)-5-(2-((2-(2-Ethoxyphenoxy)ethyl)aMino)propyl)-2-MethoxybenzenesulfonaMide 5-[(2R)-2-[[2-(2-Ethoxyphenoxy)ethyl]amino]propyl]-2-methoxybenzenesulfonamide TaMsulosin USP 5-{(2R)-2-[(2-{[2-(ethyloxy)phenyl]oxy}ethyl)amino]propyl}-2-(methyloxy)benzenesulfonamide TAMSULOSIN HCL SR PELLETS 0.2% W/W Tamsulosina [INN-Spanish] Tamsulosine [INN-French] Tamsulosinum [INN-Latin] Benzenesulfonamide, 5-[(2R)-2-[[2-(2-ethoxyphenoxy)ethyl]amino]propyl]-2-methoxy- Tamsulosin Hcl-IP/BP/USP/Ph. Eur TamsulosinQ: What is Tamsulosin Q: What is the CAS Number of Tamsulosin Q: What is the storage condition of Tamsulosin Q: What are the applications of Tamsulosin Tamsulosin 106133-20-4 TAMSOLUSIN TAMSULOSINE Tamsulosin USP/EP/BP Tamsulosin Base 5-[2-[2-(2-Ethoxyphenoxy)ethylamino]propyll-2-methoxy-benzenesulfonamide 106133-20-4 C20H28N2O5S API Tamsulosin