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ChemicalBook >> CAS DataBase List >>Carbamic acid, N-[[4-[4-[[2-(1,1-dimethylethyl)-1H-imidazol-1-yl]methyl]phenyl]-2-(2-methylpropyl)-5-thiazolyl]sulfonyl]-, methyl ester

Carbamic acid, N-[[4-[4-[[2-(1,1-dimethylethyl)-1H-imidazol-1-yl]methyl]phenyl]-2-(2-methylpropyl)-5-thiazolyl]sulfonyl]-, methyl ester

Carbamic acid, N-[[4-[4-[[2-(1,1-dimethylethyl)-1H-imidazol-1-yl]methyl]phenyl]-2-(2-methylpropyl)-5-thiazolyl]sulfonyl]-, methyl ester Structure
Carbamic acid, N-[[4-[4-[[2-(1,1-dimethylethyl)-1H-imidazol-1-yl]methyl]phenyl]-2-(2-methylpropyl)-5-thiazolyl]sulfonyl]-, methyl ester structure
CAS No.
2709031-17-2
Chemical Name:
Carbamic acid, N-[[4-[4-[[2-(1,1-dimethylethyl)-1H-imidazol-1-yl]methyl]phenyl]-2-(2-methylpropyl)-5-thiazolyl]sulfonyl]-, methyl ester
Synonyms
AT2R antagonist 1;Carbamic acid, N-[[4-[4-[[2-(1,1-dimethylethyl)-1H-imidazol-1-yl]methyl]phenyl]-2-(2-methylpropyl)-5-thiazolyl]sulfonyl]-, methyl ester
CBNumber:
CB313158845
Molecular Formula:
C23H30N4O4S2
Molecular Weight:
490.64
MDL Number:
MOL File:
2709031-17-2.mol
Last updated:2025-04-29 09:03:59
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Carbamic acid, N-[[4-[4-[[2-(1,1-dimethylethyl)-1H-imidazol-1-yl]methyl]phenyl]-2-(2-methylpropyl)-5-thiazolyl]sulfonyl]-, methyl ester Properties

Density 1.28±0.1 g/cm3(Predicted)
pka 3.63±0.10(Predicted)

Carbamic acid, N-[[4-[4-[[2-(1,1-dimethylethyl)-1H-imidazol-1-yl]methyl]phenyl]-2-(2-methylpropyl)-5-thiazolyl]sulfonyl]-, methyl ester Chemical Properties,Uses,Production

Uses

AT2R antagonist 1 (compound 21) is a potent and high selective AT2R (angiotensin II AT2 receptor) ligand. AT2R antagonist 1 exhibits a fair AT2R affinity, with a Ki of 29 nM. AT2R antagonist 1 also inhibits common agent-metabolizing CYP enzymes. AT2R antagonist 1 shows high stability in human, rat and mouse liver microsomes[1].

IC 50

AT2 Receptor

References

[1] Bolteau R, et al. Quinazoline and phthalazine derivatives as novel melatonin receptor ligands analogues of agomelatine. Eur J Med Chem. 2020 Mar 1;189:112078. DOI:10.1016/j.ejmech.2020.112078

Carbamic acid, N-[[4-[4-[[2-(1,1-dimethylethyl)-1H-imidazol-1-yl]methyl]phenyl]-2-(2-methylpropyl)-5-thiazolyl]sulfonyl]-, methyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

Carbamic acid, N-[[4-[4-[[2-(1,1-dimethylethyl)-1H-imidazol-1-yl]methyl]phenyl]-2-(2-methylpropyl)-5-thiazolyl]sulfonyl]-, methyl ester Suppliers

Global( 2)Suppliers
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TargetMol Chemicals Inc. 		+8613564774135 zijue.cai@tsbiochem.com United States 19897 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 19820 58
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TargetMol Chemicals Inc. 		58
TargetMol Chemicals Inc. 58

View Lastest Price from Carbamic acid, N-[[4-[4-[[2-(1,1-dimethylethyl)-1H-imidazol-1-yl]methyl]phenyl]-2-(2-methylpropyl)-5-thiazolyl]sulfonyl]-, methyl ester manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
AT2R antagonist 1 pictures 2025-04-29 AT2R antagonist 1
2709031-17-2
 US $1520.00-2500.00 / mg 10g TargetMol Chemicals Inc.
Carbamic acid, N-[[4-[4-[[2-(1,1-dimethylethyl)-1H-imidazol-1-yl]methyl]phenyl]-2-(2-methylpropyl)-5-thiazolyl]sulfonyl]-, methyl ester AT2R antagonist 1 2709031-17-2