4-acetylphenyloxooxazolidinylmethylacetamide
- CAS No.
- 104421-21-8
- Chemical Name:
- 4-acetylphenyloxooxazolidinylmethylacetamide
- Synonyms
- DuP-721;4-acetylphenyloxooxazolidinylmethylacetamide;N-[[(5S)-3-(4-Acetylphenyl)-2-oxooxazolidin-5-yl]methyl]acetamide;N-[[(5S)-2-Oxo-3-(4-acetylphenyl)-5α-oxazolidinyl]methyl]acetamide;N-[[(5S)-3-(4-Acetylphenyl)-2-oxooxazolidin-5α-yl]methyl]acetamide;N-{[(5S)-3-(4-acetylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}acetamide;Dup-721,M. tuberculosis,anti-tuberculosis,Mycobacterium tuberculosis,Inhibitor,M. intracellulare,inhibit,M. kansassi,Dup 721,Dup721,Antibiotic,Bacterial
- CBNumber:
- CB31349321
- Molecular Formula:
- C14H16N2O4
- Molecular Weight:
- 276.29
- MDL Number:
- MFCD30564792
- MOL File:
- 104421-21-8.mol
4-acetylphenyloxooxazolidinylmethylacetamide Chemical Properties,Uses,Production
Biological Activity
DuP-721 is a broad spectrum and orally active antibacterial agent against a variety of clinically susceptible and resistant bacteria, especially M. tuberculosis[1]. DuP-721 (1.5-4 μg/ml) inhibits equally the strains of Mycobacterium tuberculosis susceptible and resistant to conventional antituberculosis drug. And it does not show cross resistance to any of the anti-tuberculosis drugs tested[1].DuP-721 is inactive against M. avium and M. intracellulare at 250 μg/ml. It inhibits M. gordonoe and M. fortuitum at 3.9 μg/ml and M. kansassi and M. scrofulaceum at 1.95 μg/ml and 15.6 μg/ml, respectively[1]. DuP-721 (oral gavage; 50-160 mg/kg) is protective against M. tuberculosis infection in mice. DuP-721 protects 100% of the infected animals at 50 mg/kg p.o. dose when administered daily for 17 days, and the same effect is observed at 160 mg/kg dose when the drug is administered only on day 11 and 12 post infection[1].
References
[1]. Affiliatio, et al. Antimycobacterial activities of oxazolidinones: a review. Infect Disord Drug Targets. 2006 Dec;6(4):343-54.
4-acetylphenyloxooxazolidinylmethylacetamide Preparation Products And Raw materials
Raw materials
Preparation Products
4-acetylphenyloxooxazolidinylmethylacetamide Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32957 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32165 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38632 | 58 | |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4512 | 55 | |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8011 | 62 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 +86-13028896684; | sales@rrkchem.com | China | 57412 | 58 |
| Shanghai Dexuan Pharmaceutical Technology Co., Ltd | 1701086315 | dexuanpharma@126.com | China | 9475 | 58 |
| Chengdu PEIP Pharmaceutical Technology Co., LTD. | 028-61715638 18011352545 | 1242335275@qq.com | China | 344 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24647 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 4933 | 58 |
