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5,12-dihydroquinoxalino[2,3-b]quinoxaline

5,12-dihydroquinoxalino[2,3-b]quinoxaline structure

CAS No.: 531-46-4

Chemical Name:: 5,12-dihydroquinoxalino[2,3-b]quinoxaline

Synonyms: ML-090;Fluoflavine;5,12-dihydroquinoxalino[2,3-b]quinoxaline;6,11-dihydroquinoxalino[2,3-b]quinoxaline;Quinoxalino[2,3-b]quinoxaline, 5,11-dihydro-;5,12-Dihydroquinoxalino[2,3-b]quinoxaline (~90%);NOX4,ML090,NADPH Oxidase,Inhibitor,NOX,HEK293 cell,NOX3,ML 090,NOX2,inhibit,ML-090,NOX1

CBNumber:: CB31549066

Molecular Formula:: C14H10N4

Molecular Weight:: 234.26

MDL Number:: MFCD00160739

MOL File:: 531-46-4.mol

Last updated:2023-11-24 16:35:17

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5,12-dihydroquinoxalino[2,3-b]quinoxaline Properties

Melting point	>262°C (dec.)
Boiling point	450.2±28.0 °C(Predicted)
Density	1.43±0.1 g/cm3(Predicted)
storage temp.	-20°C Freezer
solubility	DMSO (Slightly, Heated, Sonicated)
form	Solid
pka	3.94±0.20(Predicted)
color	Off-White to Dark Yellow
InChI	InChI=1S/C14H10N4/c1-2-6-10-9(5-1)15-13-14(16-10)18-12-8-4-3-7-11(12)17-13/h1-8H,(H,15,17)(H,16,18)
InChIKey	WGKYYZDYHYOKQV-UHFFFAOYSA-N
SMILES	N1C2=C(C=CC=C2)N=C2NC3=C(N=C12)C=CC=C3

5,12-dihydroquinoxalino[2,3-b]quinoxaline price More Price(7)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	S920371	5,12-DIHYDROQUINOXALINO(2,3-B)QUINOXALINE AldrichCPR	531-46-4	50MG	$179	2024-03-01	Buy
Cayman Chemical	15172	ML-090 ≥95%	531-46-4	10mg	$32	2024-03-01	Buy
Cayman Chemical	15172	ML-090 ≥95%	531-46-4	25mg	$70	2024-03-01	Buy
Cayman Chemical	15172	ML-090 ≥95%	531-46-4	50mg	$116	2024-03-01	Buy
TRC	D451743	5,12-Dihydroquinoxalino[2,3-b]quinoxaline(~90%)	531-46-4	5mg	$60	2021-12-16	Buy

Product number	Packaging	Price	Buy
S920371	50MG	$179	Buy
15172	10mg	$32	Buy
15172	25mg	$70	Buy
15172	50mg	$116	Buy
D451743	5mg	$60	Buy

5,12-dihydroquinoxalino[2,3-b]quinoxaline Chemical Properties,Uses,Production

Description

NADPH oxidase 1 (NOX1) generates reactive oxygen species (ROS) in colon epithelial cells that interacts with both pathogenic and normal bacteria. Excess ROS production, however, is associated with damage to the intestinal mucosa, inflammatory bowel disease, and prostate cancer. ML-090 is the first identified NOX1-specific inhibitor (IC₅₀ = 360 nM in HEK293 cells) based on a quinoxaline scaffold that demonstrates potent selectivity over NOX2, NOX3, and NOX4 (IC₅₀s ≥ 10 μM) and xanthine oxidase (IC₅₀ = 3.5 μM).

Uses

5,12-Dihydroquinoxalino[2,3-b]quinoxaline is an inhibitor of?NADPH oxidase 1 (NOX1).

Definition

ChEBI: 6,11-dihydroquinoxalino[2,3-b]quinoxaline is a quinoxaline derivative.

5,12-dihydroquinoxalino[2,3-b]quinoxaline Preparation Products And Raw materials

Raw materials

Preparation Products

5,12-dihydroquinoxalino[2,3-b]quinoxaline Suppliers

Global( 17)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	+86-18341751992 +86-15382112998	757984502@qq.com	China	892	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52927	58
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9707	58
Shanghai TenSus Biotechnology Co., Ltd.	021-50895067 18616507272	tensus@163.com	China	4207	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11289	58
MedBioPharmaceutical Technology Inc	021-69568360 18916172912	order@med-bio.cn	China	8141	58
Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd	0431-80514535 19917294565	caoy@chemextension.com	China	4069	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24017	58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	024-024-88590548 18341751992	757984502@qq.com	China	892	58

Supplier	Advantage
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	58
TargetMol Chemicals Inc.	58
Aladdin Scientific	58
Shanghai EFE Biological Technology Co., Ltd.	58
Shanghai TenSus Biotechnology Co., Ltd.	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	58
MedBioPharmaceutical Technology Inc	58
Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd	58
TargetMol Chemicals Inc.	58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	58

5,12-dihydroquinoxalino[2,3-b]quinoxaline Spectrum

5,12-dihydroquinoxalino[2,3-b]quinoxaline(531-46-4)¹HNMR

5,12-dihydroquinoxalino[2,3-b]quinoxaline Fluoflavine ML-090 Quinoxalino[2,3-b]quinoxaline, 5,11-dihydro- 5,12-Dihydroquinoxalino[2,3-b]quinoxaline (~90%) 6,11-dihydroquinoxalino[2,3-b]quinoxaline NOX4,ML090,NADPH Oxidase,Inhibitor,NOX,HEK293 cell,NOX3,ML 090,NOX2,inhibit,ML-090,NOX1 531-46-4