Ziconotide Polyacetate
- CAS No.
- 107452-89-1
- Chemical Name:
- Ziconotide Polyacetate
- Synonyms
- snx111;Ziconotide;ω-conotoxin mviia;OMEGA-CGTX MVII A;o-Conotoxin MVIIA;Zicontide Acetate;ω-Conotoxin MVIIA;ZICONOTIDE ACETATE;SNX-111, Ziconotide;OMEGA-CONOTOXIN MVIIA
- CBNumber:
- CB3190092
- Molecular Formula:
- C102H172N36O32S7
- Molecular Weight:
- 2639.13
- MDL Number:
- MFCD00145036
- MOL File:
- 107452-89-1.mol
- MSDS File:
- SDS
Density | 1.60±0.1 g/cm3(Predicted) |
---|---|
storage temp. | -20°C |
solubility | DMSO (Slightly, Sonicated), Methanol (Slightly) |
form | Solid |
color | White to Off-White |
InChIKey | BPKIMPVREBSLAJ-QTBYCLKRSA-N |
NCI Dictionary of Cancer Terms | SNX 111; ziconotide |
FDA UNII | 7I64C51O16 |
NCI Drug Dictionary | ziconotide |
ATC code | N02BG08 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS06 |
---|---|
Signal word | Danger |
Hazard statements | H301+H331 |
Precautionary statements | P261-P304+P340+P312-P403+P233 |
RIDADR | 3172 |
WGK Germany | 3 |
HazardClass | 6.1(b) |
PackingGroup | III |
Ziconotide Polyacetate price More Price(4)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | C1182 | ω-Conotoxin MVIIA ≥95% (HPLC) | 107452-89-1 | 0.1mg | $260 | 2022-05-15 | Buy |
Sigma-Aldrich | C1182 | ω-Conotoxin MVIIA ≥95% (HPLC) | 107452-89-1 | 0.5mg | $938 | 2022-05-15 | Buy |
TRC | Z385000 | ZiconotidePolyacetate | 107452-89-1 | 2.5mg | $3390 | 2021-12-16 | Buy |
Biosynth Carbosynth | FC110295 | Omega-Conotoxin MVIIA | 107452-89-1 | 500ug | $600 | 2021-12-16 | Buy |
Ziconotide Polyacetate Chemical Properties,Uses,Production
Description
ω-conotoxin MVIIA, also knwn as Ziconotide acetate, is a peptide consisting of 25 amino acid. It is a disulfide-bridged polypeptide from the venom of the sea snail Conusmagus that binds to neuronal N-type calcium channels. It forms a compact folded structure, presenting a loop between Cys8 and Cys15 that contains a set of residues critical for its binding. Both ω-conotoxins GVIA and MVIIA could bind to neuronal N-type calcium channels. ω-conotoxin GVIA is rich in hydroxyl groups while ω-conotoxin MVIIA contains a large number of positively charged side chains[1-2].
Uses
Ziconotide acetate (ω-Conotoxin MVIIA), the peptide toxin of the Conus magus (cone snail) is a selective antagonist of N-type voltage sensitive calcium channels (VSCC). As a most well-known identified conotoxin so far, it has been used as a effective drug to treat intractable chronic pain in cancer and ADIS patients[2]. Blocks neurotransmitter release by preventing depolarization-induced calcium influx. Used as a ligand for binding studies of voltage sensitive calcium channels. Analgesic; neuroprotective.
brand name
Prialt (Elan).
General Description
ω-Conotoxin MVIIA functions as a selective inhibitor of N-type voltage-sensitive calcium channels (VSCCs). It has analgesic and neuroprotective effects. ω-Conotoxin MVIIA is used to treat neuropathic pain.
Biochem/physiol Actions
Neuronal N-type Ca2+ channel blocker in mammalian and amphibian brain; blocks release of GABA and glutamate at neuronal synapses.
References
[1] Wang R, et al. Development of an ic-ELISA and immunochromatographic strip based on IgG antibody for detection of ω-conotoxin MVIIA. Journal of Hazardous Materials, 2019; 378: 120510.
[2] Zhou Y, et al. A Chemoenzymatic Approach To Produce a Cyclic Analogue of the Analgesic Drug MVIIA (Ziconotide). Angew. Chem. Int. Ed., 2023; 62: e202302812.
Ziconotide Polyacetate Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hantai Biomedical Group Co. LTD | +8618819265912 | id002@cnhantide.com | China | 37 | 58 |
henan kanbei chemical co.,ltd | +undefined-86-1523780-4566 +undefined15237804566 | henankanbeichemical@163.com | China | 511 | 58 |
Henan Bao Enluo International TradeCo.,LTD | +86-17331933971 +86-17331933971 | deasea125996@gmail.com | China | 2503 | 58 |
Wuhan Haorong Biotechnology Co.,ltd | +86-18565342920; +8618565342920 | sales@chembj.net | China | 289 | 58 |
Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 10991 | 58 |
Nantong Guangyuan Chemicl Co,Ltd | +undefined17712220823 | admin@guyunchem.com | China | 616 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20291 | 58 |
Shanghai Affida new material science and technology center | +undefined15081010295 | admin@oudaxin.com | China | 114 | 58 |
Alpha Biopharmaceuticals Co., Ltd | +86-15542445688 | sales@alabiochem.com | China | 888 | 58 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18628 | 58 |
View Lastest Price from Ziconotide Polyacetate manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-09-18 | Ziconotide acetate
107452-89-1
|
US $0.00 / mg | 1mg | 99% | 10kg/month | WUHAN FORTUNA CHEMICAL CO., LTD | ||
2024-09-11 | Zicontide Acetate
107452-89-1
|
US $0.00-0.00 / box | 1box | 99 | 50000KG/month | Shanghai Affida new material science and technology center | ||
2024-09-09 | Ziconotide acetate
107452-89-1
|
US $0.00-0.00 / kg | 20kg | 99% | 200000 | Wuhan Haorong Biotechnology Co.,Ltd |
- Ziconotide acetate
107452-89-1
- US $0.00 / mg
- 99%
- WUHAN FORTUNA CHEMICAL CO., LTD
- Zicontide Acetate
107452-89-1
- US $0.00-0.00 / box
- 99
- Shanghai Affida new material science and technology center
- Ziconotide acetate
107452-89-1
- US $0.00-0.00 / kg
- 99%
- Wuhan Haorong Biotechnology Co.,Ltd