(S)-2,6-Diamino-N-[(1-(1-oxotridecyl)-2-piperidinyl)methyl]hexanamide hydrate dihydrochloride
![(S)-2,6-Diamino-N-[(1-(1-oxotridecyl)-2-piperidinyl)methyl]hexanamide hydrate dihydrochloride Structure](CAS/GIF/141774-20-1.gif)
- CAS No.
- 141774-20-1
- Chemical Name:
- (S)-2,6-Diamino-N-[(1-(1-oxotridecyl)-2-piperidinyl)methyl]hexanamide hydrate dihydrochloride
- Synonyms
- NPC-15437 (hydrochloride);NPC-15437 dihydrochloride hydrate;(S)-2,6-Diamino-N-[(1-(1-oxotridecyl)-2-piperidinyl)methyl]hexanamide dihydrochloride hydrate;(S)-2,6-Diamino-N-[(1-(1-oxotridecyl)-2-piperidinyl)methyl]hexanamide hydrate dihydrochloride
- CBNumber:
- CB32129564
- Molecular Formula:
- C25H50N4O22HCl
- Molecular Weight:
- 529.63
- MDL Number:
- MFCD00210207
- MOL File:
- 141774-20-1.mol
(S)-2,6-Diamino-N-[(1-(1-oxotridecyl)-2-piperidinyl)methyl]hexanamide hydrate dihydrochloride Properties
| storage temp. | 2-8°C |
|---|---|
| solubility | H2O: soluble10mg/mL, clear |
| form | powder |
| color | white |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 3 months. |
(S)-2,6-Diamino-N-[(1-(1-oxotridecyl)-2-piperidinyl)methyl]hexanamide hydrate dihydrochloride price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | N161 | NPC-15437 dihydrochloride hydrate ≥97% (NMR), powder | 141774-20-1 | 25mg | $1310 | 2022-05-15 | Buy |
| Cayman Chemical | 20212 | NPC-15437 (hydrochloride) ≥95% | 141774-20-1 | 500μg | $38 | 2024-03-01 | Buy |
| Cayman Chemical | 20212 | NPC-15437 (hydrochloride) ≥95% | 141774-20-1 | 1mg | $71 | 2024-03-01 | Buy |
| Cayman Chemical | 20212 | NPC-15437 (hydrochloride) ≥95% | 141774-20-1 | 5mg | $292 | 2024-03-01 | Buy |
| TRC | N185500 | N161 | 141774-20-1 | 2.5mg | $605 | 2021-12-16 | Buy |
(S)-2,6-Diamino-N-[(1-(1-oxotridecyl)-2-piperidinyl)methyl]hexanamide hydrate dihydrochloride Chemical Properties,Uses,Production
Description
NPC-15437 (141774-20-1) is a potent and selective inhibitor of protein kinase C which binds to the regulatory domain (IC50=19 μM).1,2 It specifically interacts with the C1 domain of PKC.3 Important tool for assessing the role of PKC in various signaling pathways.4??Cell permeable.?Active?in vivo.4
Uses
N 161 is a selective protein kinase C (PKC) inhibitor. PKC is involved with signal transduction cascades related to immune response, cell growth, and memory.
References
References/Citations 1) Sullivan et al. (1992), 2,6-Diamino-N-([1-(1-oxotridecyl)-2-piperidinyl]methyl)hexanamide (NPC 15437): a novel inhibitor of protein kinase C interacting at the regulatory domain; Mol. Pharmacol., 41 38 2) Sullivan et al. (1991), 2,6-Diamino-N-([1-oxotridecyl)-2-piperidinyl]methyl)hexanamide (NPC 15437): a selective inhibitor of protein kinase C; Agents Actions 34 142 3) Sullivan et al. (1991), NPC 15437 interacts with the C1 domain of protein kinase C. An analysis using mutant PKC constructs; FEBS Lett., 285 120 4) Miyoshi et al. (2007), mGlu5 receptor and protein kinase C implicated in the development and induction of neuropathic pain following chronic ethanol consumption; Eur. J. Pharmacol., 562 208
(S)-2,6-Diamino-N-[(1-(1-oxotridecyl)-2-piperidinyl)methyl]hexanamide hydrate dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
(S)-2,6-Diamino-N-[(1-(1-oxotridecyl)-2-piperidinyl)methyl]hexanamide hydrate dihydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| Jinan ponder chemical co. LTD | 0531-0000 | thinklifescience@163.com | China | 19690 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8739 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 28118 | 58 |
| Supplier | Advantage |
|---|---|
| Aladdin Scientific | 58 |
| BOC Sciences | 65 |
| Jinan ponder chemical co. LTD | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 58 |
| TargetMol Chemicals Inc. | 58 |