Bisindolylmaleimide VIII acetate salt
- CAS No.
- 138516-31-1
- Chemical Name:
- Bisindolylmaleimide VIII acetate salt
- Synonyms
- Bis VIII acetate;RO 31-7549 ACETATE;BISINDOLYLMALEIMIDE VIII ACETATE SALT;BisindolylMaleiMide VIII . AcOH [Ro 31-7549];3-(1-(3-Aminopropyl)-1H-indol-3-yl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione acetate;3-[1-(3-Aminopropyl)-1H-indol-3-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione monoacetate;1H-Pyrrole-2,5-dione, 3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1-methyl-1H-indol-3-yl)-, acetate (1:1);protein,Bisindolylmaleimide VIII acetate,Ro 31-7549,Inhibitor,inhibit,Fas,Bis VIII,Apoptosis,autoimmune,Protein kinase C,diseases,kinase,cell-mediated,Bisindolylmaleimide VIII,PKC
- CBNumber:
- CB32130296
- Molecular Formula:
- C24H22N4O2
- Molecular Weight:
- 398.464
- MDL Number:
- MFCD00909467
- MOL File:
- 138516-31-1.mol
Bisindolylmaleimide VIII acetate salt price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 13333 | Bisindolylmaleimide VIII (acetate) ≥98% | 138516-31-1 | 1mg | $50 | 2024-03-01 | Buy |
| Cayman Chemical | 13333 | Bisindolylmaleimide VIII (acetate) ≥98% | 138516-31-1 | 5mg | $183 | 2024-03-01 | Buy |
| Cayman Chemical | 13333 | Bisindolylmaleimide VIII (acetate) ≥98% | 138516-31-1 | 10mg | $341 | 2024-03-01 | Buy |
| TRC | B448500 | BisindolylmaleimideVIIIAceticAcidSalt | 138516-31-1 | 10mg | $175 | 2021-12-16 | Buy |
| Adipogen Life Sciences | AG-CR1-0114-M001 | BisindolylmaleimideVIII.acetate ≥98%(NMR) | 138516-31-1 | 1mg | $45 | 2021-12-16 | Buy |
Bisindolylmaleimide VIII acetate salt Chemical Properties,Uses,Production
Uses
It is a potent inhibitor of protein kinase C (PKC) activity. Bisindolylmaleimide VIII (Bis VIII) has been previously shown to enhance Fas-mediated apoptosis through a protein kinase C-independent mechanism.
Biological Activity
bisindolylmaleimide viii is a protein kinase c (pkc) inhibitor.the protein kinase c (pkc) consists of a family of closely related isoenzymes mediating various signal transduction processes. the ten isoenzymes that have been currently identified can be divided into three families on the basis of their different requirements for activation. members of the conventional pkc family are ca2+ and phospholipid-dependent and are activated by diacylglycerols and phorbol esters.
in vitro
previous study found that bisindolylmaleimides carrying a straight-chain alkyl side-chain bearing a cationic substituent, such as ro 31-7549 (bisindolylmaleimide viii) and ro 31-8220, showed a significant improvement in potency over the simple bisindolylmaleimides. for bisindolylmaleimide viii, a further improvement in potency was obtained by restricting the position of the amine substituent. moreove, unlike the indolocarbazole, staurosporine, which displayed 2-fold selectivity for pkc-β over the other examined isoenzymes, bisindolylmaleimide viii exhibited a slight selectivity for pkc-α over the other isoenzymes. compounds such as bisindolylmaleimide viii carrying a straight-chain alkyl side-chain with the cationic substituent were found to be equipotent as inhibitors of pkc-β, pkc-γ and pkc-ε [1].
in vivo
animal study found that, in neonatal rats, high glucose levels could induce the hypertrophy of cardiomyocytes. ro-31-8220, a analog of bisindolylmaleimide viii, was able to reverse the effect of high glucose on the cardiac myocytes,which might be through pkc/nf-κb/c-fos pathway [2].
IC 50
158 nm for rat brain pkc
References
[1] wilkinson, s. e.,parker, p.j. and nixon, j.s. isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase c. biochemistry journal 294, 335-337 (1993).
[2] zhang, w. b. et al. reverse effect of protein kinase c inhibitor ro-31-8220 on the hypertrophy of cardiomyocytes of neonatal rats induced by high glucose levels. chinese journal of pathophysiology. 2009-08.
Bisindolylmaleimide VIII acetate salt Preparation Products And Raw materials
Raw materials
Preparation Products
Bisindolylmaleimide VIII acetate salt Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32165 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38632 | 58 | |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57505 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7887 | 56 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9806 | 58 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8011 | 62 |
| Shanghai Rechem science Co., Ltd. | 21-31433387 15618786686 | sales@rechemscience.com | China | 2927 | 58 |
| Shanghai Chaolan Chemical Technology Center | 021-QQ：65489617 15618227136 | Sales@ATKchemical.com | China | 7268 | 58 |
View Lastest Price from Bisindolylmaleimide VIII acetate salt manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | Bisindolylmaleimide VIII acetate
138516-31-1
|
US $39.00-149.00 / mg | 99.27% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-11-19 | Bisindolylmaleimide VIII acetate
138516-31-1
|
US $39.00-149.00 / mg | 99.27% | 10g | TargetMol Chemicals Inc. |
-
- Bisindolylmaleimide VIII acetate
138516-31-1
- US $39.00-149.00 / mg
- 99.27%
- TargetMol Chemicals Inc.
-
- Bisindolylmaleimide VIII acetate
138516-31-1
- US $39.00-149.00 / mg
- 99.27%
- TargetMol Chemicals Inc.