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Tyr-α-CGRP (human)

Tyr-α-CGRP (human) Structure
Tyr-α-CGRP (human) structure
CAS No.
124756-98-5
Chemical Name:
Tyr-α-CGRP (human)
Synonyms
Tyr-α-CGRP (human);Tyr-a-CGRP (huMan);Tyr-α-CGRP (human);Tyr-α-CGRP (huMan) Tyr-CGRP I (huMan);Tyr-α-CGRP (huMan) Tyr-CGRP I (huMan);Tyr-α-CGRP (human) (trifluoroacetate salt);α-Calcitonin gene-related peptide (human), N-L-tyrosyl- (9CI);H-Tyr-Ala-Cys-Asp-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asn-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe-NH2
CBNumber:
CB32477229
Molecular Formula:
C174H277F3N52O53S2
Molecular Weight:
4066.5029896
MDL Number:
MOL File:
124756-98-5.mol
Last updated:2023-05-21 10:59:17
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Tyr-α-CGRP (human) Properties

storage temp. Store at -20°C
solubility Water: 1 mg/ml
form A lyophilized powder

Tyr-α-CGRP (human) price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 24724 Tyr-α-CGRP (human) (trifluoroacetate salt) ≥95% 124756-98-5 1 mg $305 2024-03-01 Buy
Cayman Chemical 24724 Tyr-α-CGRP (human) (trifluoroacetate salt) ≥95% 124756-98-5 500μg $211 2023-01-06 Buy
Product number Packaging Price Buy
24724 1 mg $305 Buy
24724 500μg $211 Buy

Tyr-α-CGRP (human) Chemical Properties,Uses,Production

Description

Tyr-α-CGRP is an N-terminal extended tyrosinated analogue of α-calcitonin gene-related peptide (α-CGRP; ).1 It binds to amylin receptors AMY1 and AMY3 in COS-7 cells expressing the human receptors (IC50s = 141 and 1.86 nM, respectively).2 Tyr-α-CGRP also binds to and stimulates cAMP accumulation in rat L6 myocytes (IC50 = 4 nM; EC50 = 12 nM).1 It also binds to rat brain and spleen membrane preparations (IC50s = 0.2 and 0.5 nM, respectively), induces positive chronotropic and inotropic effects in isolated right and left guinea pig atria (EC50s = 282 and 74 nM, respectively), and inhibits the twitch response in rat vas deferens (EC50 = 1.9 nM).3

References

1. Poyner, D.R., Andrew, D.P., Brown, D., et al. Pharmacological characterization of a receptor for calcitonin gene-related peptide on rat, L6 myocytes Br. J. Pharmacol. 105(2),441-447(1992).
2. Hay, D.L., Christopoulos, G., Christopoulos, A., et al. Pharmacological discrimination of calcitonin receptor: Receptor activity-modifying protein complexes Mol. Pharmacol. 67(5),1655-1665(2005).
3. Dennis, T., Fournier, A., St. Pierre, S., et al. Structure-activity profile of calcitonin gene-related peptide in peripheral and brain tissues. Evidence for receptor multiplicity J. Pharmacol. Exp. Ther. 251(2),718-725(1989).

Tyr-α-CGRP (human) Preparation Products And Raw materials

Raw materials

Preparation Products

Tyr-α-CGRP (human) Suppliers

Global( 29)Suppliers
Supplier Tel Email Country ProdList Advantage
Cellmano Biotech Limited 		0551-65326643 18156095617 info@cellmano.com China 999 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30238 58
Nanjing TGpeptide 		+86-13347807150 +86-13347807150 support@tgpeptide.com China 3279 58
Changsha MOL Changes Biotechnology Co., Ltd. 		+8619375158599 info@molchanges.com China 5223 58
GL Biochem (Shanghai) Ltd 21-61263452 13641803416 ymbetter@glbiochem.com China 9981 64
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42958 64
Chemsky (shanghai) International Co.,Ltd 021-50135380 shchemsky@sina.com China 15402 60
Cellmano Biotech Limited 0551-65326643 18156095617 info@cellmano.com China 1011 55
Creative Peptides info@creative-peptides.com United States 6083 56
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9806 58
Supplier Advantage
Cellmano Biotech Limited 		58
Career Henan Chemica Co 		58
Nanjing TGpeptide 		58
Changsha MOL Changes Biotechnology Co., Ltd. 		58
GL Biochem (Shanghai) Ltd 64
Shanghai Hanhong Scientific Co.,Ltd. 64
Chemsky (shanghai) International Co.,Ltd 60
Cellmano Biotech Limited 55
Creative Peptides 56
Shanghai EFE Biological Technology Co., Ltd. 58

124756-98-5(Tyr-α-CGRP (human))Related Search:

TYR-CORTICOTROPIN RELEASING FACTOR HUMAN, RAT TYR-ARG-PRO-PRO-GLY-PHE-SER-PRO-PHE-ARG H-TYR-SER-GLN-GLU-PRO-PRO-ILE-SER-LEU-ASP-LEU-THR-PHE-HIS-LEU-LEU-ARG-GLU-VAL-LEU-GLU-MET-THR-LYS-ALA-ASP-GLN-LEU-ALA-GLN-GLN-ALA-HIS-SER-ASN-ARG-LYS-LEU-LEU-ASP-ILE-ALA-NH2 TYR-AMYLOID P COMPONENT (27-38) AMIDE
Tyr-α-CGRP (human) Tyr-α-CGRP (huMan) Tyr-CGRP I (huMan) H-Tyr-Ala-Cys-Asp-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asn-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe-NH2 Tyr-a-CGRP (huMan) Tyr-α-CGRP (human) (trifluoroacetate salt) Tyr-α-CGRP (huMan) Tyr-CGRP I (huMan) Tyr-α-CGRP (human) α-Calcitonin gene-related peptide (human), N-L-tyrosyl- (9CI) 124756-98-5