2'-O-(2-Methoxyethyl)cytidine
- CAS No.
- 223777-16-0
- Chemical Name:
- 2'-O-(2-Methoxyethyl)cytidine
- Synonyms
- 2'-MOE-C;2'-MOE-rC;2'-O-MOE-rC;2'-O-MOE-Cr;2'-MOE-Cytidine;2'-O-MOE Cytidine;2'-O-MOE Cytidine;2'-O-(2-mthoxyethyl)Cytidine;2'-O-(2-Methoxyethyl)cytidine;2'-O-(2-Methoxyethyl)cytidine
- CBNumber:
- CB32510559
- Molecular Formula:
- C12H19N3O6
- Molecular Weight:
- 301.3
- MDL Number:
- MFCD17215637
- MOL File:
- 223777-16-0.mol
Boiling point | 535.3±60.0 °C(Predicted) |
---|---|
Density | 1.57±0.1 g/cm3(Predicted) |
storage temp. | 2-8°C |
solubility | DMSO : 250 mg/mL (829.74 mM) |
pka | 13.36±0.70(Predicted) |
form | Solid |
color | White to off-white |
InChI | InChI=1S/C12H19N3O6/c1-19-4-5-20-10-9(17)7(6-16)21-11(10)15-3-2-8(13)14-12(15)18/h2-3,7,9-11,16-17H,4-6H2,1H3,(H2,13,14,18)/t7-,9-,10-,11-/m1/s1 |
InChIKey | YKOGMMXZKKVMBT-QCNRFFRDSA-N |
SMILES | OC[C@H]1O[C@@H](N2C=CC(N)=NC2=O)[C@H](OCCOC)[C@@H]1O |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302-H315-H319-H335 |
Precautionary statements | P261-P305+P351+P338 |
2'-O-(2-Methoxyethyl)cytidine price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
TRC | M262570 | 2''-O-(2-Methoxyethyl)cytidine | 223777-16-0 | 25mg | $1760 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | NUC0002420 | 2'-O-(2-METHOXYETHYL)CYTIDINE 95.00% | 223777-16-0 | 0.25G | $786 | 2021-12-16 | Buy |
Biosynth Carbosynth | NM16315 | 2'-O-(2-Methoxyethyl)cytidine | 223777-16-0 | 500mg | $115 | 2021-12-16 | Buy |
AK Scientific | 1312AB | 2'-O-(2-Methoxyethyl)-cytidine | 223777-16-0 | 1g | $320 | 2021-12-16 | Buy |
AK Scientific | 1312AB | 2'-O-(2-Methoxyethyl)-cytidine | 223777-16-0 | 2g | $455 | 2021-12-16 | Buy |
2'-O-(2-Methoxyethyl)cytidine Chemical Properties,Uses,Production
Description
2'-O-(2-Methoxyethyl)-cytidine is a cytidine derivative that can be used as a building block for crosslinking oligonucleotides. 2'-O-(2-Methoxyethyl)-cytidine is also used as a texturizing agent in food products.
Uses
A cytidine derivative as building blocks for cross-linking oligonucleotides.
Synthesis
2'-O-(2-Methoxyethyl)uridine could be converted into the corresponding cytidine derivative (2'-O-(2-Methoxyethyl)cytidine) by the 4-nitrophenylation[1]. 2'-O-(2-Methoxyethyl)uridine, l-methylpyrrolidine, chlorotrimethylsilane and dry acetonitrile were stirred together at rt. After 1 h, the reaction mixture was cooled to 0 ℃, and trifluoroacetic anhydride was added dropwise over 5 min. After a further period of 30 rain at 0 ℃, 4-nitrophenol was added to the stirred reactants which were maintained at 0 °C. After 3 h, the products were poured into saturated aqueous sodium hydrogen carbonate, and the resulting mixture was extracted with dichloromethane. The combined organic layers were dried, and evaporated under reduced pressure. Concentrated aqueous ammonia was added to a stirred solution of the residue in dioxane, contained in a sealed flask that was then heated at 55°C for 24 h. The resulting yellow solution was concentrated under reduced pressure and the residue was evaporated with absolute ethanol. The products were fractionated by short column chromatography on silica gel and were evaporated under reduced pressure to give 2'-O-(2-Methoxyethyl)cytidine as an off-white solid.
References
[1] Urtzi et al. "Conversion of uridine into 2′-O-(2-methoxyethyl)uridine and 2′-O-(2-methoxyethyl)cytidine." Tetrahedron (1999).
2'-O-(2-Methoxyethyl)cytidine Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Yunbio Tech Co.,Ltd. | +86-010-60605551 +86-18046518538 | yunbiochem@126.com | China | 321 | 58 |
Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10311 | 58 |
Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 7621 | 58 |
Nanjing Baifuli Technology Co., Ltd. | +86-15335185688 | sales@unisyn.cn | CHINA | 332 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49392 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29821 | 58 |
Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9641 | 58 |
SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 13392 | 58 |
Finetech Industry Limited | +86-27-87465837 +8618971612321 | info@finetechnology-ind.com | China | 9640 | 58 |
View Lastest Price from 2'-O-(2-Methoxyethyl)cytidine manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-08-07 | 2'-O-(2-Methoxyethyl)cytidine
223777-16-0
|
US $0.00-0.00 / KG | 1KG | 99% | 200KG per month | Yunbio Tech Co.,Ltd. | ||
2023-04-04 | 2'-O-(2-Methoxyethyl)cytidine
223777-16-0
|
US $0.00-0.00 / kg | 1kg | 98% | 500kg per month | Zhejiang Hengkang Pharmaceutical Co., Ltd. | ||
2023-03-22 | 2'-O-(2-methoxyethyl)-Cytidine;2’-MOE-C
223777-16-0
|
US $100.00 / kg | 0.009999999776482582kg | 99% | 5tons | SHANGHAI NOVRIBO BIOTECH |
- 2'-O-(2-Methoxyethyl)cytidine
223777-16-0
- US $0.00-0.00 / KG
- 99%
- Yunbio Tech Co.,Ltd.
- 2'-O-(2-Methoxyethyl)cytidine
223777-16-0
- US $0.00-0.00 / kg
- 98%
- Zhejiang Hengkang Pharmaceutical Co., Ltd.
- 2'-O-(2-methoxyethyl)-Cytidine;2’-MOE-C
223777-16-0
- US $100.00 / kg
- 99%
- SHANGHAI NOVRIBO BIOTECH
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