ChemicalBook >> CAS DataBase List >>2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-[4-(1-methylpropyl)phenyl]acetamide

2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-[4-(1-methylpropyl)phenyl]acetamide

2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-[4-(1-methylpropyl)phenyl]acetamide structure

CAS No.: 332117-28-9

Chemical Name:: 2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-[4-(1-methylpropyl)phenyl]acetamide

Synonyms: CS-1651;TCS 5861528;CheMbridge 5861528;Chembridge-5861528, 10 mM in DMSO;TCS 5861528;TCS-5861528;TCS5861528;CHEMBRIDGE-5861528;TCS-5861528;TCS5861528;N-(4-(sec-Butyl)phenyl)-2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)acetamide;N-[4-(butan-2-yl)phenyl]-2-(1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-7-yl)acetamide;7H-Purine-7-acetamide, 1,2,3,6-tetrahydro-1,3-dimethyl-N-[4-(1-methylpropyl)phenyl]-2,6-dioxo-;2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-[4-(1-methylpropyl)phenyl]acetamide

CBNumber:: CB32518883

Molecular Formula:: C19H23N5O3

Molecular Weight:: 369.42

MDL Number:: MFCD01993436

MOL File:: 332117-28-9.mol

MSDS File:: SDS

Last updated:2025-04-17 18:22:24

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2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-[4-(1-methylpropyl)phenyl]acetamide Properties

Density	1.30±0.1 g/cm3(Predicted)
storage temp.	Store at RT
solubility	DMSO : 74 mg/mL (200.31 mM; Need ultrasonic and warming)
form	Powder
pka	13.75±0.70(Predicted)
color	White to off-white

2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-[4-(1-methylpropyl)phenyl]acetamide price More Price(22)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	18380	TCS 5861528 ≥98%	332117-28-9	5mg	$81	2024-03-01	Buy
Cayman Chemical	18380	TCS 5861528 ≥98%	332117-28-9	10mg	$158	2024-03-01	Buy
Cayman Chemical	18380	TCS 5861528 ≥98%	332117-28-9	25mg	$356	2024-03-01	Buy
Cayman Chemical	18380	TCS 5861528 ≥98%	332117-28-9	50mg	$632	2024-03-01	Buy
Tocris	3938	TCS5861528 ≥98%(HPLC)	332117-28-9	50	$690	2021-12-16	Buy

Product number	Packaging	Price	Buy
18380	5mg	$81	Buy
18380	10mg	$158	Buy
18380	25mg	$356	Buy
18380	50mg	$632	Buy
3938	50	$690	Buy

2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-[4-(1-methylpropyl)phenyl]acetamide Chemical Properties,Uses,Production

Uses

TCS 5861528 is a TRPA1 channel antagonist, which may prevent development of diabetic hypersensitivity.

in vivo

Chembridge-5861528 (TCS 5861528) (30 mg/kg; i.p.; twice daily for a week) significantly attenuates development of mechanical hypersensitivity in Streptozocin (HY-13753)-induced diabetes mellitus rat model^[1].
Chembridge-5861528 (3 and 10 μg/rat; i.t.; once) attenuates Capsaicin.html" class="link-product" target="_blank">Capsaicin (HY-10448)-induced blood flow increase in a dose-related fashion^[2].

Animal Model:	Male Hannover-Wistar rats, Streptozocin-induced diabetes mellitus model^[1]
Dosage:	30 mg/kg
Administration:	Intraperitoneal injection, twice daily for a week
Result:	Significantly attenuated development of mechanical hypersensitivity as revealed by the paw pressure test (F^1,80= 31.4, P < 0.0001).

Animal Model:	Male Hannover–Wistar rats (220-260 g), Capsaicin-induced neurogenic inflammation model^[2]
Dosage:	0, 3, and 10 μg/rat
Administration:	Intrathecal injection, 20 min before Capsaicin injection
Result:	Significantly decreased the blood flow at 10 μg.

IC 50

TRPA1: 14.3 μM (IC₅₀, allyl isothiocyanate-evoked TRPA1 response); TRPA1: 18.7 μM (IC₅₀, 4-HNE-evoked TRPA1 response)

storage

Store at RT

2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-[4-(1-methylpropyl)phenyl]acetamide Preparation Products And Raw materials

Raw materials

Preparation Products

2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-[4-(1-methylpropyl)phenyl]acetamide Suppliers

Global( 72)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32202	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43340	58
Aladdin Scientific		tp@aladdinsci.com	United States	57505	58
DAYANG CHEM (HANGZHOU) CO.,LTD	+8617705817739	info@dycnchem.com	China	53881	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131957	58
	821-50328103-801 18930552037	3bsc@sina.com	China	15839	69
Haoyuan Chemexpress Co., Ltd.	021-58950125	info@chemexpress.com	China	7552	61
MedChemexpress LLC	021-58955995	sales@medchemexpress.cn	United States	4861	58
AdooQ Bioscience CHINA	025-58849295 18951903616;	info@adooq.cn	China	2990	60

Supplier	Advantage
TargetMol Chemicals Inc.	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58
LEAPCHEM CO., LTD.	58
Aladdin Scientific	58
DAYANG CHEM (HANGZHOU) CO.,LTD	58
Amadis Chemical Company Limited	58
	69
Haoyuan Chemexpress Co., Ltd.	61
MedChemexpress LLC	58
AdooQ Bioscience CHINA	60

View Lastest Price from 2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-[4-(1-methylpropyl)phenyl]acetamide manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-04-27	Chembridge-5861528 332117-28-9	US $35.00-113.00 / mg		100%	10g	TargetMol Chemicals Inc.

Chembridge-5861528
332117-28-9
US $35.00-113.00 / mg
100%
TargetMol Chemicals Inc.

2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-[4-(1-methylpropyl)phenyl]acetamide Spectrum

2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-[4-(1-methylpropyl)phenyl]acetamide(332117-28-9)¹HNMR

332117-28-9(2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-[4-(1-methylpropyl)phenyl]acetamide)Related Search:

6-Chloro-N4-[3,5-difluoro-4-[(3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,4-pyrimidinediamine

2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-[4-(1-methylpropyl)phenyl]acetamide TCS 5861528 CheMbridge 5861528 TCS 5861528;TCS-5861528;TCS5861528 CS-1651 CHEMBRIDGE-5861528;TCS-5861528;TCS5861528 7H-Purine-7-acetamide, 1,2,3,6-tetrahydro-1,3-dimethyl-N-[4-(1-methylpropyl)phenyl]-2,6-dioxo- N-(4-(sec-Butyl)phenyl)-2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)acetamide Chembridge-5861528,Chembridge 5861528,diabetes mellitus,Transient receptor potential channels,Inhibitor,inhibit,TCS-5861528,antihypersensitivity,neurogenic inflammation,TRP Channel,TCS5861528,Chembridge5861528 N-[4-(butan-2-yl)phenyl]-2-(1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-7-yl)acetamide Chembridge-5861528, 10 mM in DMSO 332117-28-9 Inhibitors