CAL-101
- CAS No.
- 870281-82-6
- Chemical Name:
- CAL-101
- Synonyms
- Idelalisib(CAL-101);-101;CS-34;GS1101;AL-101;CAL-11;CAL-101;CAL-101 1KG;CAL101,CAL-101;CAL-101, >=98%
- CBNumber:
- CB32538915
- Molecular Formula:
- C22H18FN7O
- Molecular Weight:
- 415.42
- MDL Number:
- MFCD19443647
- MOL File:
- 870281-82-6.mol
Melting point | 250-252oC |
---|---|
Boiling point | 733.4±70.0 °C(Predicted) |
Density | 1.47 |
storage temp. | -20°C |
solubility | Soluble in DMSO (>25 mg/ml) |
form | White solid. |
pka | 10.00±0.10(Predicted) |
color | White |
Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months. |
FDA UNII | YG57I8T5M0 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS08 |
---|---|
Signal word | Danger |
Hazard statements | H372 |
Precautionary statements | P260-P264-P270-P314-P501 |
Safety Statements | V |
HS Code | 29399990 |
CAL-101 price More Price(30)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 15279 | CAL-101 ≥98% | 870281-82-6 | 5mg | $33 | 2024-03-01 | Buy |
Cayman Chemical | 15279 | CAL-101 ≥98% | 870281-82-6 | 10mg | $63 | 2024-03-01 | Buy |
Cayman Chemical | 15279 | CAL-101 ≥98% | 870281-82-6 | 25mg | $107 | 2024-03-01 | Buy |
Cayman Chemical | 15279 | CAL-101 ≥98% | 870281-82-6 | 50mg | $164 | 2024-03-01 | Buy |
TRC | C124800 | CAL-101 | 870281-82-6 | 100mg | $285 | 2021-12-16 | Buy |
CAL-101 Chemical Properties,Uses,Production
Description
Idelalisib (CAS 870281-82-6) is a potent (IC50 = 2.5nM) and selective (IC50’s: PI3Ka = 820nM, PI3Kb = 565nM, PI3Kg = 89nM) PI3Kd inhibitor.1,2 Useful clinical agent for the treatment of various blood cancers. Idelalisib attenuates regulatory T cells (Treg) but not conventional T cells (Tconv) resulting in a significant increase in tumor-infiltrating antigen-specific CD8 T cells in a murine lung cancer model.3 Conversely, systemic PI3Kd inactivation antagonized anti-CTLA-4 and anti-PD-L1 treatment.4 Others have found that Idelalisib minimally influenced rituximab- and obinutuzumab-mediated Ab-dependent cellular cytotoxicity in human lymphoma cells.5
Uses
CAL-101 is a PI3K/mTOR pathway inhibitor used in the treatment of myeloid leukemia through sensitizing the cells to combatting drugs. Potent PI3K-p110-delta inhibitor.
Definition
ChEBI: A member of the class of quinazolines that is 5-fluoro-3-phenylquinazolin-4-one in which the hydrogen at position 2 is replaced by a (1S)-1-(3H-purin-6-ylamino)propyl group. used for for the treatment of refractory indol nt non-Hodgkin's lymphoma and relapsed chronic lymphocytic leukemia.
target
p110δ
storage
Store at -20°C
References
1) Herman?et al. (2010), Phosphatidylinositol 2-kinase-d inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals; Blood?116 2078 2) Lannutti?et al. (2011), CAL-101, a p110d selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability; Blood 117 591 3) Ahmad?et al. (2017), Differential PI3Kd Signaling in CD4+ T-cell Subsets Enables Selective Targeting of T Regulatory Cells to Enhance Cancer Immunotherapy; Cancer Res. 77 1892 4) Lim?et al. (2018), Phosphoinositide 3-kinase d inhibition promotes antitumor responses but antagonizes checkpoint inhibitors; JCI Insight 3 e120626 5) Palazzo?et al.?(2018),?The PI3Kd-Selective Inhibitor Idelalisib Minimally Interferes with Immune Effector Function Mediated by Rituximab or Obinutuzumab and Significantly Augment B Cell Depletion In Vivo; J.Immunol. 200 2304
![870281-86-0](/CAS/GIF/870281-86-0.gif)
![87-42-3](/CAS/GIF/87-42-3.gif)
![870281-82-6](/CAS/20150408/GIF/870281-82-6.gif)
CAL-101 Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Changzhou Rokechem Technology Co., Ltd. | 18758118018 | sales001@rokechem.com | China | 255 | 58 |
Hebei Yanxi Chemical Co., Ltd. | +86-17531190177; +8617531190177 | peter@yan-xi.com | China | 5873 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32760 | 60 |
Lianyungang happen teng technology co., LTD | 15950718863 | wang666xt@163.com | CHINA | 295 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29894 | 58 |
Zhejiang ZETian Fine Chemicals Co. LTD | +8618957127338 | stella@zetchem.com | China | 2136 | 58 |
Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
Hangzhou Cyanochem Co., Ltd. | +86 17788583750 | sales@cyanochem.com | CHINA | 283 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
View Lastest Price from CAL-101 manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
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2024-08-15 | CAL-101
870281-82-6
|
US $0.00 / kg | 1kg | 0.99 | 20tons | Hebei Yanxi Chemical Co., Ltd. | |
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2024-07-26 | Idelalisib
870281-82-6
|
US $0.00 / kg | 1kg | 98% HPLC | 500 kgs | PUSHAN INDUSTRIAL (SHAANXI) CO.,LTD | |
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2022-10-01 | Idelalisib
870281-82-6
|
US $0.00-0.00 / kg | 1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. |
-
- CAL-101
870281-82-6
- US $0.00 / kg
- 0.99
- Hebei Yanxi Chemical Co., Ltd.
-
- Idelalisib
870281-82-6
- US $0.00 / kg
- 98% HPLC
- PUSHAN INDUSTRIAL (SHAANXI) CO.,LTD
-
- Idelalisib
870281-82-6
- US $0.00-0.00 / kg
- 98%
- Henan Aochuang Chemical Co.,Ltd.