4-Iodo Suberoylanilide HydroxaMic Acid
- CAS No.
- 1219807-87-0
- Chemical Name:
- 4-Iodo Suberoylanilide HydroxaMic Acid
- Synonyms
- 4-iodo-SAHA;4-Iodo Suberoylanilide HydroxaMic Acid;N1-Hydroxy-N8-(4-iodophenyl)octanediaMide;Octanediamide, N1-hydroxy-N8-(4-iodophenyl)-
- CBNumber:
- CB32544804
- Molecular Formula:
- C14H19IN2O3
- Molecular Weight:
- 390.22
- MDL Number:
- MOL File:
- 1219807-87-0.mol
4-Iodo Suberoylanilide HydroxaMic Acid price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 10495 | 4-iodo-SAHA ≥98% | 1219807-87-0 | 50mg | $89 | 2024-03-01 | Buy |
| Cayman Chemical | 10495 | 4-iodo-SAHA ≥98% | 1219807-87-0 | 100mg | $168 | 2024-03-01 | Buy |
| Cayman Chemical | 10495 | 4-iodo-SAHA ≥98% | 1219807-87-0 | 250mg | $395 | 2024-03-01 | Buy |
| Cayman Chemical | 10495 | 4-iodo-SAHA ≥98% | 1219807-87-0 | 500mg | $700 | 2024-03-01 | Buy |
| Usbiological | 014903 | 4-Iodo Suberoylanilide Hydroxamic Acid | 1219807-87-0 | 100mg | $446 | 2021-12-16 | Buy |
4-Iodo Suberoylanilide HydroxaMic Acid Chemical Properties,Uses,Production
Uses
A SAHA derivative with antiproliferative activity in several human cancer cell lines. Antitumor agent.
Biological Activity
4-iodo-saha is a hydrophobic derivative of saha, the class i and class ii histone deacetylase (hdac) inhibitor [1].the reversible acetylation of lysine residues in histone plays an important role in transcriptional activation and repression. the regulation of these post-translational modifications is balanced by histone acetyltransferase (hat) and histone deacetylase (hdac) activities. hdacs are also involved in reversible acetylation of non-histone proteins [1].4-iodo-saha is a histone deacetylase (hdac) inhibitor. in skbr3-breast-derived cell line, 4-iodo-saha inhibited cell proliferation with ec50 value of 1.1 μm. in ht29 colon-derived cell line, leukemia-derived u937 tumor cell line, ja16, hl60 and k562 cell lines, 4-iodo-saha inhibited cell proliferation with ec50 values of 0.95, 0.12, 0.24, 0.85 and 1.3 μm, respectively. 4-iodo-saha is 10-fold more potent as an inhibitor of u937 leukemia cell proliferation compared to saha (0.12 μm versus 1.2 μm). in skbr3 cells, 4-iodo-saha reduced acetylated h4 and p21 levels [1].
References
[1]. salmi-smail c, fabre a, dequiedt f, et al. modified cap group suberoylanilide hydroxamic acid histone deacetylase inhibitor derivatives reveal improved selective antileukemic activity. j med chem. 2010 apr 22;53(8):3038-47.
4-Iodo Suberoylanilide HydroxaMic Acid Preparation Products And Raw materials
Raw materials
Preparation Products
4-Iodo Suberoylanilide HydroxaMic Acid Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 94658 | 76 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15421 | 60 |
| Shanghai TaoSu Biochemical Technology Co., Ltd. | 021-33632979 | info@tsbiochem.com | China | 8072 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | 400-+86-400-002-6226 | sales@rrkchem.com | China | 56077 | 58 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44843 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
| InvivoChem | 13549236410 | sales@invivochem.cn | China | 6755 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 23963 | 58 |