BML-286
- CAS No.
- 294891-81-9
- Chemical Name:
- BML-286
- Synonyms
- BML-286;2-[[3-[(phenylacetyl)aMino]benzoyl]aMino]benzoic Acid;2-[[3-[(2-phenylacetyl)aMino]benzoyl]aMino]benzoic Acid;Benzoic acid, 2-[[3-[(2-phenylacetyl)amino]benzoyl]amino]-;Dvl-PDZ Domain Inhibitor II - CAS 294891-81-9 - Calbiochem
- CBNumber:
- CB32557989
- Molecular Formula:
- C22H18N2O4
- Molecular Weight:
- 374.39
- MDL Number:
- MOL File:
- 294891-81-9.mol
- MSDS File:
- SDS
BML-286 price More Price(3)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 322338 | Dvl-PDZ Domain Inhibitor II - CAS 294891-81-9 - Calbiochem | 294891-81-9 | 10mg | $144 | 2024-03-01 | Buy |
TRC | B595870 | BML-286 | 294891-81-9 | 50mg | $165 | 2021-12-16 | Buy |
Usbiological | 004331 | BML-286 | 294891-81-9 | 50mg | $460 | 2021-12-16 | Buy |
BML-286 Chemical Properties,Uses,Production
Uses
BML-286 is a small molecule inhibitor of the PDZ domain of Dishevelled (Dvl): an essential protein in the Wnt signaling pathways. This compound reduced the levels of apoptosis in the hyaloid vessels of the eye and also suppressed the growth of prostate cancer PC-3 cells. It is a useful tool for studies dissecting the Wnt signaling pathways.
Definition
ChEBI: 2-[[oxo-[3-[(1-oxo-2-phenylethyl)amino]phenyl]methyl]amino]benzoic acid is a member of benzamides.
General Description
A cell-permeable amidobenzanilide compound that disrupts Fz-Dvl (frizzled-dishevelled) interaction by targeting the PDZ domain (Kd = 10.6 μM) of Dvl, blocking Wnt3a-induced (10 ng/ml) transcription activity (~50% inhibition at 3 μM in 293 cell SuperTopflash reporter assays) and suppressing the Wnt pathway-dependent growth of prostate cancer PC-3 cells (by 16% in 72 h at ≥50 μM; IC50 = 12.5 μM). Shown to effectively prevent Wnt3A mRNA injection-induced xenopus embryo deformation (effective conc. = 25 μM) and suppress Wnt pathway-mediated apoptosis of the hyaloid vescular endothelial cells in the mouse eyes via vitreous injection (144 fmol/120 nl/eye) in vivo.
BML-286 Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15421 | 60 |
Shanghai TaoSu Biochemical Technology Co., Ltd. | 021-33632979 | info@tsbiochem.com | China | 8072 | 58 |
Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9806 | 58 |
Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 | sales@rrkchem.com | China | 56086 | 58 |
Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44941 | 58 |
Changzhou Furuisi Biotechnology Co., Ltd | 0519-85524369 | 3477467573@qq.com | China | 8618 | 58 |
Jinan Jiuli Biotechnology Co. , Ltd. | 15865264761 | 486064515@qq.com | China | 3336 | 58 |