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Vilanterol Trifenatate

Vilanterol Trifenatate structure

CAS No.: 503070-58-4

Chemical Name:: Vilanterol Trifenatate

Synonyms: vilanterol trifenatate;Vilanterol Trifenate;Vilanterol triphenylacetate;GW642444M;GW 642444M;GW-642444M;GW642444M Trifenate;GW642444 (trifenatate);Vilanterol Trifenatate (API);GW642444M; GW 642444M; GW-642444M

CBNumber:: CB32563287

Molecular Formula:: C44H49Cl2NO7

Molecular Weight:: 774.78

MDL Number:: MFCD28978327

MOL File:: 503070-58-4.mol

MSDS File:: SDS

Last updated:2024-11-12 15:22:14

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Vilanterol Trifenatate Properties

Melting point	131.9-134.2℃
storage temp.	Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility	Dichloromethane (Slightly), Methanol (Slightly)
form	Solid
color	White to Off-White
Stability	Hygroscopic
InChIKey	KLOLZALDXGTNQE-NETKZVBLNA-N
SMILES	C(C1C=CC=CC=1)(C1C=CC=CC=1)(C1C=CC=CC=1)C(=O)O.[C@H](C1C=CC(O)=C(CO)C=1)(O)CNCCCCCCOCCOCC1C(=CC=CC=1Cl)Cl \|&1:22,r\|
FDA UNII	40AHO2C6DG

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319
Precautionary statements	P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313

Vilanterol Trifenatate price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML3389	Vilanterol trifenatate ≥95% (HPLC)	503070-58-4	10MG	$86.5	2024-03-01	Buy
Sigma-Aldrich	SML3389	Vilanterol trifenatate ≥95% (HPLC)	503070-58-4	50MG	$350	2024-03-01	Buy
TRC	V260000	VilanterolTrifenatate	503070-58-4	5mg	$225	2021-12-16	Buy
ChemScene	CS-1679	Vilanterol(trifenatate) 99.20%	503070-58-4	5mg	$100	2021-12-16	Buy
ChemScene	CS-1679	Vilanterol(trifenatate) 99.20%	503070-58-4	10mg	$150	2021-12-16	Buy

Product number	Packaging	Price	Buy
SML3389	10MG	$86.5	Buy
SML3389	50MG	$350	Buy
V260000	5mg	$225	Buy
CS-1679	5mg	$100	Buy
CS-1679	10mg	$150	Buy

Vilanterol Trifenatate Chemical Properties,Uses,Production

Chemical Properties

Vilanterol trifenatate is a white powder with a molecular weight of 774.8, and the empirical formula is C24H33Cl2NO5.C20H16O2. It insoluble in water and slightly soluble in methanol, ethanol, acetonitrile and propan-2-ol. It is slightly hygroscopic. It is provided in a micronized form.

Uses

Vilanterol Trifenatate is a long-acting β2 adrenergic receptor Agonist with alonger than 24-hour activity in humans, and is being developed to be used in combination with FF. It is also highly selective for the β2-receptor, with over 1000-fold greater selectivity compared to β1-receptors. It demonstrates prolonged bronchodilation in subjects with asthma and COPD.

Preparation

Vilanterol trifenatate is synthesized by incorporation of an oxygen atom at the homobenzylic position of the right-hand side phenyl ring of (R)-salmeterol and has suitable chemical properties for inhaled administration. The combination in fluticasone furoate (FF) and vilanterol trifenatate (VI) in a single inhaler is the first once daily combination available on the market for the treatment of stable COPD.

Definition

ChEBI: Vilanterol Trifenatate is a triphenylacetate salt obtained by combining vilanterol with one equivalent of triphenylacetic acid. Used in combination with fluticasone furoate for treatment of bronchospasm associated with chronic obstructive pulmonary disease. It has a role as a beta-adrenergic agonist and a bronchodilator agent. It contains a vilanterol(1+).

Biological Activity

vilanterol trifenatate is a novel and selective agonist of β2-ar with a pec50 value of 10.37±0.05 [1].vilanterol trifenatate is a novel long-acting β2-ar agonist (laba) with 24h activity in development for inhaled once daily treatment. in the radioligand binding studies, vilanterol trifenatate has shown the binding affinity in the one-affinity site model with pkd values of 9.44±0.07 and 10.82±0.12 in the presence gpp(nh)p and absence gpp(nh)p, respectively. in dissociation studies, vilanterol trifenatate has been reported to bind from the β2-ar with a dissociation t1/2 value of 3.5 min in the presence of gpp(nh)p. vilanterol trifenatate has been found to have a good selectivity for β2-ar over the other β-ar receptor subtypes(β1and β3) with pec50 values of 10.37±0.05, 6.98±0.03 and 7.36±0.03, respectively. vilanterol trifenatate has exhibited at least 1000-fold selectivity over both β1-and β3-ar subtypes [1].

Dosage

The recommended and maximum dose is one inhalation of vilanterol trifenatate 25 micrograms once daily either morning or evening but at the same time every day.

Mode of action

Vilanterol Trifenatate is a selective long-acting beta2-receptor agonist (also referred to as a LABA). The pharmacologic effects of beta2-adrenoceptor agonist drugs, including vilanterol trifenatate, are at least in part attributable to stimulation of intracellular adenylate cyclase, the enzyme that catalyses the conversion of adenosine triphosphate (ATP) to cyclic-3',5'-adenosine monophosphate (cyclic AMP). Increased cyclic AMP levels cause relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells.

References

[1] slack rj1, barrett vj, morrison vs, sturton rg, emmons aj, ford aj, knowles rg.in vitro pharmacological characterization of vilanterol, a novel long-acting β2-adrenoceptor agonist with 24-hour duration of action.j pharmacol exp ther. 2013 jan; 344(1):218-30.

Vilanterol Trifenatate synthesis

Synthesis of Vilanterol Trifenatate from Vilanterol and Triphenylacetic acid

Vilanterol Trifenatate Preparation Products And Raw materials

Raw materials

4H-1,3-Benzodioxin, 6-[(1R)-2-bromo-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-2,2-dimethyl- (1R)-2-[[6-[2-[(2,6-Dichlorobenzyl)oxy]ethoxy]hexyl]aMino]-1-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)ethanol 2-Bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone 2-Oxazolidinone, 5-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)-, (5R)- Vilanterol

Triphenylacetic acid

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Preparation Products

Vilanterol Trifenatate Suppliers

Global( 196)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Protheragen-ING	+16313385890	info@protheragen-ing.com	United States	3868	58
AFINE CHEMICALS LIMITED	+86-0571-85134551	sales@afinechem.com	China	15352	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8617865335152	Mandy@hangyubiotech.com	China	10986	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21634	55
Hangzhou FandaChem Co.,Ltd.	+8615858145714	FandaChem@Gmail.com	China	9087	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32957	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29880	58
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	965	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58

Supplier	Advantage
Protheragen-ING	58
AFINE CHEMICALS LIMITED	58
Zibo Hangyu Biotechnology Development Co., Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
Hangzhou FandaChem Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Biochempartner	58
Hubei xin bonus chemical co. LTD	58
BOC Sciences	58

View Lastest Price from Vilanterol Trifenatate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-12-13	Vilanterol trifenatate 503070-58-4	US $0.00-0.00 / g	1g	98.0%	500g/month	WUHAN FORTUNA CHEMICAL CO., LTD
2024-08-27	Vilanterol Trifenatate 503070-58-4	US $70.00-700.00 / kg	10kg	0.99	20tons	Zibo Hangyu Biotechnology Development Co., Ltd
2024-04-02	Vilanterol Trifenatate 503070-58-4	US $10.00-100.00 / kg	1kg	99%	100 tons	Wuhan Xinhao Biotechnology Co., Ltd

Vilanterol trifenatate
503070-58-4
US $0.00-0.00 / g
98.0%
WUHAN FORTUNA CHEMICAL CO., LTD

Vilanterol Trifenatate
503070-58-4
US $70.00-700.00 / kg
0.99
Zibo Hangyu Biotechnology Development Co., Ltd

Vilanterol Trifenatate
503070-58-4
US $10.00-100.00 / kg
99%
Wuhan Xinhao Biotechnology Co., Ltd

Vilanterol Trifenatate Spectrum

Vilanterol Trifenatate(503070-58-4)¹HNMR

503070-58-4(Vilanterol Trifenatate)Related Search:

Carbamic acid, N-[2-(2,2-dimethyl-4H-1,3-benzodioxin-5-yl)-2-oxoethyl]-, 1,1-dimethylethyl ester Benzaldehyde, 5-[(1R)-2-[[6-[2-[(2,6-dichlorophenyl)methoxy]ethoxy]hexyl]amino]-1-hydroxyethyl]-2-hydroxy- Phenylacetyl chloride 1,4-Phenylenediacetic acid Ethylenediaminetetraacetic acid

Vilanterol Vilanterol Impurity 14 Vilanterol Impurity 22(Vilanterol-d4 Triphenylacetate) Vilanterol Impurity 3 Triphenylacetate Vilanterol Impurity 6 Triphenylacetate

5-(2,2-diMethyl-4H-benzo[d][1,3]dioxin-6-yl)oxazolidin-2-one Vilanterol Impurity 23 Vilanterol Impurity 7 Triphenylacetate Vilanterol Impurity 25 (1R)-2-[[6-[2-[(2,6-Dichlorobenzyl)oxy]ethoxy]hexyl]aMino]-1-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)ethanol

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Benzeneacetic acid, α,α-diphenyl-, coMpd. with (α1R)-α1-[[[6-[2-[(2,6-dichlorophenyl)Methoxy]ethoxy]hexyl]aMino]Methyl]-4-hydroxy-1,3-benzenediMethanol (1:1) GW 642444M GW642444M GW-642444M Vilanterol Trifenatate (API) 4-[(R)-2-[[6-[2-(2,6-Dichlorobenzyloxy)ethoxy]hexyl]amino]-1-hydroxyethyl]-2-(hydroxymethyl)phenol triphenylacetate GW642444M; GW 642444M; GW-642444M Benzeneacetic acid, α,α-diphenyl-, coMpd. with (α1R)-α1-6-2-(2,6-dichlorophenyl)MethoxyethoxyhexylaMinoMethyl-4-hydroxy-1,3-benzenediMethanol (1 GW642444 (trifenatate) (R)-4-(2-((6-(2-((2,6-dichlorobenzyl)oxy)ethoxy)hexyl)amino)-1-hydroxyethyl)-2-(hydroxymethyl)phenyl 2,2,2-triphenylacetate Pharmaceuticals Chemical Vilanterol Trifenatate Powder Benzeneacetic acid, α,α-diphenyl-, coMpd. with (α1R)-α1-[[[6-[2-[(2,6-dichlorophenyl)Methoxy]ethoxy]hexyl]aMino]Methyl]-4-hydroxy-1,3-benzenediMethanol (1 GW642444M Trifenate (R)-4-(2-((6-(2-((2,6-dichlorobenzyl)oxy)ethoxy)hexyl)amino)-1-hydroxyethyl)-2-(hydroxymethyl)phenol2,2,2-triphenylacetate Vilanterol TrifenatateQ: What is Vilanterol Trifenatate Q: What is the CAS Number of Vilanterol Trifenatate Q: What is the storage condition of Vilanterol Trifenatate Q: What are the applications of Vilanterol Trifenatate Benzeneacetic acid, α,α-diphenyl-, coMpd. with (α1R)-α1-[[[6-[2-[(2,6-dichlorophenyl)Methoxy]ethoxy]hexyl]aMino]Methyl]-4-hydroxy-1,3-benzenediMethanol (1:1) 503070-58-4 Benzeneacetic acid, α,α-diphenyl-, coMpd. with (α1R)-α1-[[[6-[2-[(2,6-dichlorophenyl)Methoxy]ethoxy]hexyl]aMino]Methyl]-4-hydroxy-1,3-benzenediMethanol (1:1) vilanterol trifenatate Vilanterol Trifenate Vilanterol triphenylacetate VilanterolImpurity8Triphenylacetate 1-(3-(6-((pyridin-3-ylmethyl)amino)-1H-pyrrolo[2,3-b]pyridin-4-yl)phenyl)ethan-1-ol 503070-58-4 C44H49Cl2NO7 C24H33Cl2NO5C20H16O2 Intermediate 503070-58-4