2-GUANIDINOETHYLMERCAPTOSUCCINIC ACID
- CAS No.
- 77482-44-1
- Chemical Name:
- 2-GUANIDINOETHYLMERCAPTOSUCCINIC ACID
- Synonyms
- GEMSA;2-Guanidinoethylthiosuccinic acid;GUANIDINOETHYLMERCAPTO-SUCCINIC ACID;2-GUANIDINOETHYLMERCAPTOSUCCINIC ACID;2-(2-Guanidinoethylthio)succinic acid;2-[(2-Guanidinoethyl)thio]succinic acid;(2-Guanidinoethylthio)succinic acid, GEMSA;(2-GUANIDINOETHYLMERCAPTO)SUCCINIC ACID 99+%;2-Guanidinoethylmercaptosuccinic acid (GEMSA);2-[(2-carbaMiMidaMidoethyl)sulfanyl]succinicacid
- CBNumber:
- CB3257755
- Molecular Formula:
- C7H13N3O4S
- Molecular Weight:
- 235.26
- MDL Number:
- MFCD00036862
- MOL File:
- 77482-44-1.mol
SAFETY
Risk and Safety Statements
| Safety Statements | 22-24/25 |
|---|
2-GUANIDINOETHYLMERCAPTOSUCCINIC ACID price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 369334 | 2-Guanidinoethylmercaptosuccinic Acid | 77482-44-1 | 5mg | $245 | 2024-03-01 | Buy |
| Cayman Chemical | 19354 | 2-Guanidinoethylmercaptosuccinic Acid ≥98% | 77482-44-1 | 5mg | $183 | 2024-03-01 | Buy |
| ApexBio Technology | C3265 | 2-Guanidinoethylmercaptosuccinic Acid | 77482-44-1 | 5mg | $201 | 2021-12-16 | Buy |
2-GUANIDINOETHYLMERCAPTOSUCCINIC ACID Chemical Properties,Uses,Production
Biological Activity
ki: 8.8 nm2-guanidinoethylmercaptosuccinic acid is a carboxypeptidase e inhibitor.carboxypeptidase e, also known as enkephalin convertase, can remove c-terminal residues during the processing of propeptides, such as enkephalin and proinsulin.
in vitro
2-guanidinoethylmercaptosuccinic acid was identified as a biproduct analogs of lysine and arginine that showed potent inhibitory effect on enkephalin convertase with the ki value of 8.8 nm. in addition, 2-guanidinoethylmercaptosuccinic acid was found to be several hundred fold more potent towards enkephalin convertase than towards carboxypeptidase b or n and the kinetic analyses indicated the pure competitive nature of the inhibition [1].
in vivo
previous study found that following the intrathecal administration of 2-guanidinoethylmercaptosuccinic acid at 12.5, 25 and 50 micrograms, an increase in the tail-flick latency was seen. in addition, 2-guanidinoethylmercaptosuccinic acid could potentiate the analgesic effects of the intrathecally applied met5-enkephalin-arg6-phe7 and met5-enkephalin-arg6-gly7-leu8. all these effects of 2-guanidinoethylmercaptosuccinic acid were significantly attenuated by the treatment of naloxone. moreover, the rats subjected to chronic pain showed a weaker analgesic response to the treatment of 2-guanidinoethylmercaptosuccinic acid. furthermore, 2-guanidinoethylmercaptosuccinic acid bound to enkephalin convertase in the spinal cord of these rats produced only a slight increase in kd [2].
References
1. fricker ld, plummer th jr, snyder sh. enkephalin convertase: potent, selective, and irreversible inhibitors. biochem biophys res commun. 1983 mar 29;111(3):994-1000.2. m. bommer, k. nikolarakis, e. p. noble, et al. in vivo modulation of rat hypothalamic opioid peptide content by intracerebroventricular injection of guanidinoethylmercaptosuccinic acid (gemsa): possible physiological role of enkephalin convertase. brain research 492(1-2), 305-313 (1989).
2-GUANIDINOETHYLMERCAPTOSUCCINIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
2-GUANIDINOETHYLMERCAPTOSUCCINIC ACID Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9926 | 65 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9708 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24017 | 58 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 18621169109 | market03@meryer.com | China | 27996 | 58 |
| Shanghai Aladdin Biochemical Technology Co.,Ltd. | +86-18521732826 | market@aladdin-e.com | China | 48467 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.com | China | 24246 | 58 |
| ApexBio Technology | -- | sales@apexbt.com | United States | 6254 | 58 |