EGFR inhibitor
- CAS No.
- 879127-07-8
- Chemical Name:
- EGFR inhibitor
- Synonyms
- EGFR-IN-12;EGFR inhibitor;EGFR inhibitor 324674;EGFR inhibitor(YUN27078);EGFR Inhibitor [879127-07-8];EGFR Inhibitor [879127-07-8] - EGFR Inhibitor 324674;N-(3-((6-((3-(Trifluoromethyl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)cyclopropanecarboxamide;CyclopropanecarboxaMide, N-[3-[[6-[[3-(trifluoroMethyl)phenyl]aMino]-4-pyriMidinyl]aMino]phenyl]-;EGFR,EGFRIN12,autophosphorylation,anti-proliferation,4,6-disubstituted,antitumor,kinases,Epidermal growth factor receptor,inhibit,EGFR IN 12,AKT,pyrimidine,ErbB-1,Apoptosis,Inhibitor,HER1,Tyrosine
- CBNumber:
- CB32597567
- Molecular Formula:
- C21H18F3N5O
- Molecular Weight:
- 413.4
- MDL Number:
- MOL File:
- 879127-07-8.mol
- MSDS File:
- SDS
Boiling point | 605.9±55.0 °C(Predicted) |
---|---|
Density | 1.456±0.06 g/cm3(Predicted) |
storage temp. | Store at -20°C |
solubility | insoluble in H2O; insoluble in EtOH; ≥60.7 mg/mL in DMSO |
form | crystalline solid |
pka | 14.50±0.70(Predicted) |
color | Off-white to light yellow |
NCI Dictionary of Cancer Terms | EGFR inhibitor |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H315-H319 |
Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
EGFR inhibitor price More Price(15)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 324674 | EGFR Inhibitor - CAS 879127-07-8 - Calbiochem | 879127-07-8 | 1MG | $159 | 2024-03-01 | Buy |
Cayman Chemical | 15363 | EGFR Inhibitor ≥98% | 879127-07-8 | 1mg | $93 | 2024-03-01 | Buy |
Cayman Chemical | 15363 | EGFR Inhibitor ≥98% | 879127-07-8 | 5mg | $275 | 2024-03-01 | Buy |
Cayman Chemical | 15363 | EGFR Inhibitor ≥98% | 879127-07-8 | 25mg | $957 | 2024-03-01 | Buy |
TRC | E440158 | EGFRInhibitor | 879127-07-8 | 1mg | $115 | 2021-12-16 | Buy |
EGFR inhibitor Chemical Properties,Uses,Production
Uses
EGFR Inhibitor is a highly selective, cell-permeable EGFR inhibitor.
Biological Activity
egfr inhibitor is a cell permeable, pyrimidine compound that selectively inhibits the egfr kinase with ic50 value of 21 nm [1].egfr is a transmembrane protein, and is a receptor for members of epidermal growth factor family. the binding of egfr with its ligands induces receptor dimerization and tyrosine autophosphorylation, and leads to cell proliferation. the overactivity of egfr tyrosine kinases is associated with a number of cancers, inhibition of egfr can downregulate antiapoptotic proteins such as surviving and upregulate proapoptotic proteins such as bim. thus, egfr inhibitor can induce cell apoptosis, resulting in anti-tumor effectivity [2].egfr inhibitor inhibited egfr kinase in vitro and blocks receptor autophosphorylation in cells. egfr inhibitor also inhibited l858r and l861q egfr mutants with ic50 values of 63 and 4 nm, respectively [1].
References
1. q. zhang, y. liu, f. gao, et al. discovery of egfr selective 4,6-disubstituted pyrimidines from a combinatorial kinase-directed heterocycle library. journal of the american chemical society 128(7), 2182-2183 (2006). 2. f. ciardiello, g. tortora. egfr antagonists in cancer treatment. new england journal of medicine 358(11), 1160-1174 (2008).
EGFR inhibitor Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32835 | 60 |
Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30250 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10522 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
VDM Biochemicals | 0330-2528181 | sales@vdmbio.com | United States | 510 | 64 |
AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2784 | 58 |
Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696,15000506266 15000506266 | China | 4362 | 55 |