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ChemicalBook >> CAS DataBase List >>5-[(Z)-(5-Fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-(4-morpholinyl)propyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide (2Z)-2-butenedioate

5-[(Z)-(5-Fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-(4-morpholinyl)propyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide (2Z)-2-butenedioate

5-[(Z)-(5-Fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-(4-morpholinyl)propyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide (2Z)-2-butenedioate Structure
5-[(Z)-(5-Fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-(4-morpholinyl)propyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide (2Z)-2-butenedioate structure
CAS No.
849643-15-8
Chemical Name:
5-[(Z)-(5-Fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-(4-morpholinyl)propyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide (2Z)-2-butenedioate
Synonyms
101193;SU14813 maleate;SU-14813 MALEATE;SU 14813 MALEATE;(S,Z)-5-((5-Fluoro-2-oxoindolin-3-ylidene)methyl)-N-(2-hydroxy-3-morpholinopropyl)-2,4-dimethy;(S,Z)-5-((5-fluoro-2-oxoindolin-3-ylidene)Methyl)-N-(2-hydroxy-3-Morpholinopropyl)-2,4-diMethyl-1H-pyrrole-3-carboxaMide Maleate;5-[(Z)-(5-Fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-(4-morpholinyl)propyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide (2Z)-2-;(Z)-but-2-enedioic acid,5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-morpholin-4-ylpropyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide;5-[(Z)-(5-Fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-(4-morpholinyl)propyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide (2Z)-2-butenedioate
CBNumber:
CB32614334
Molecular Formula:
C23H27FN4O4.C4H4O4
Molecular Weight:
558.5554432
MDL Number:
MFCD24682713
MOL File:
849643-15-8.mol
MSDS File:
SDS
Last updated:2024-07-02 08:55:06
Request For Quotation

5-[(Z)-(5-Fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-(4-morpholinyl)propyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide (2Z)-2-butenedioate Properties

storage temp. Store at -20°C
solubility Soluble in DMSO
form Powder
color Yellow to orange

5-[(Z)-(5-Fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-(4-morpholinyl)propyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide (2Z)-2-butenedioate price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0649 SU14813(maleate) 99.95% 849643-15-8 10mg $114 2021-12-16 Buy
ApexBio Technology A3846 SU14813maleate 849643-15-8 2mg $126 2021-12-16 Buy
ChemScene CS-0649 SU14813(maleate) 99.95% 849643-15-8 5mg $84 2021-12-16 Buy
ApexBio Technology A3846 SU14813maleate 849643-15-8 5mg $189 2021-12-16 Buy
Matrix Scientific 143823 (S,Z)-5-((5-Fluoro-2-oxoindolin-3-ylidene)methyl)-N-(2-hydroxy-3-morpholinopropyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide maleate 95% 849643-15-8 10mg $296 2021-12-16 Buy
Product number Packaging Price Buy
CS-0649 10mg $114 Buy
A3846 2mg $126 Buy
CS-0649 5mg $84 Buy
A3846 5mg $189 Buy
143823 10mg $296 Buy

5-[(Z)-(5-Fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-(4-morpholinyl)propyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide (2Z)-2-butenedioate Chemical Properties,Uses,Production

Description

SU14813 maleate is a multi-targeted receptor tyrosine kinases inhibitor with IC50s of 50, 2, 4, 15 nM for VEGFR2, VEGFR1, PDGFRβ and KIT.

in vitro

In Vitro:SU14813 inhibits ligand-dependent and ligand-independent proliferation, migration, and survival of endothelial cells and/or tumor cells expressing these targets. SU14813 inhibits cellular ligand-dependent phosphorylation of VEGFR-2 (transfected NIH 3T3 cells), PDGFR-β (transfected NIH 3T3 cells), KIT (Mo7e cells), and FLT3-internal tandem duplication (FLT3-ITD; MV4;11 cells) as well as FMS/CSF1R (transfected NIH 3T3 cells). SU14813 inhibits VEGFR-2, PDGFR-β, and KIT phosphorylation in porcine aorta endothelial cells overexpressing these targets, with cellular IC50 values of 5.2, 9.9, and 11.2 nM, respectively. SU14813 inhibits the growth of U-118MG with an IC50 of 50 to 100 nM[1].

in vivo

In Vivo:SU14813 inhibits VEGFR-2, PDGFR-β, and FLT3 phosphorylation in xenograft tumors in a dose- and time-dependent fashion. The plasma concentration required for in vivo target inhibition is estimated to be 100 to 200 ng/mL. Used as monotherapy, SU14813 exhibits broad and potent antitumor activity resulting in regression, growth arrest, or substantially reduced growth of various established xenografts derived from human or rat tumor cell lines. Treatment in combination with docetaxel significantly enhances both the inhibition of primary tumor growth and the survival of the tumor-bearing mice compared with administration of either agent alone[1].

References

References:[1]. Patyna S, et al. SU14813: a novel multiple receptor tyrosine kinase inhibitor with potent antiangiogenic and antitumor activity. Mol Cancer Ther. 2006 Jul;5(7):1774-82.

5-[(Z)-(5-Fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-(4-morpholinyl)propyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide (2Z)-2-butenedioate Preparation Products And Raw materials

Raw materials

Preparation Products

5-[(Z)-(5-Fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-(4-morpholinyl)propyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide (2Z)-2-butenedioate Suppliers

Global( 39)Suppliers
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career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29820 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418684 +8618949823763 sales@tnjchem.com China 25363 58
Young Lively PharminBlock Co.,Ltd 		+undefined18600731423 jason_gao@yl-pharminblock.com China 1944 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131980 58
Henan Aochuang Chemical Co.,Ltd. +86-0371-63689365 +8618638391208 sales@aochuangchem.com China 9246 58
Chembest Research Laboratories Limited +86-21-20908456 sales@BioChemBest.com China 6008 61
ChemShuttle, Inc. 0510-83588313-802 18800520310; sales@chemshuttle.com China 2999 62
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7553 61
CEG Chemical Science&Technology Co., Ltd. Mobile:13665161512 China 1785 58
Supplier Advantage
career henan chemical co 		58
InvivoChem 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58
Young Lively PharminBlock Co.,Ltd 		58
Amadis Chemical Company Limited 		58
Henan Aochuang Chemical Co.,Ltd. 58
Chembest Research Laboratories Limited 61
ChemShuttle, Inc. 62
Haoyuan Chemexpress Co., Ltd. 61
CEG Chemical Science&Technology Co., Ltd. 58

View Lastest Price from 5-[(Z)-(5-Fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-(4-morpholinyl)propyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide (2Z)-2-butenedioate manufacturers

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SU14813 maleate pictures 2022-09-30 SU14813 maleate
849643-15-8
 US $0.00-0.00 / KG 1KG 98% 1ton Henan Aochuang Chemical Co.,Ltd.
5-[(Z)-(5-Fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-(4-morpholinyl)propyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide (2Z)-2-butenedioate pictures 2020-01-13 5-[(Z)-(5-Fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-(4-morpholinyl)propyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide (2Z)-2-butenedioate
849643-15-8
 US $1.00 / g 1g 98% 100KG Career Henan Chemical Co
  • SU14813 maleate pictures
  • SU14813 maleate
    849643-15-8
  • US $0.00-0.00 / KG
  • 98%
  • Henan Aochuang Chemical Co.,Ltd.
5-[(Z)-(5-Fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-(4-morpholinyl)propyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide (2Z)-2-butenedioate SU14813 maleate (S,Z)-5-((5-fluoro-2-oxoindolin-3-ylidene)Methyl)-N-(2-hydroxy-3-Morpholinopropyl)-2,4-diMethyl-1H-pyrrole-3-carboxaMide Maleate (S,Z)-5-((5-Fluoro-2-oxoindolin-3-ylidene)methyl)-N-(2-hydroxy-3-morpholinopropyl)-2,4-dimethy 101193 SU-14813 MALEATE;SU 14813 MALEATE (Z)-but-2-enedioic acid,5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-morpholin-4-ylpropyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide 5-[(Z)-(5-Fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-(4-morpholinyl)propyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide (2Z)-2- 849643-15-8 C23H27FN4O4C4H4O4