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S0859

S0859 structure

CAS No.: 1019331-10-2

Chemical Name:: S0859

Synonyms: S0859;100852;CS-1766;NBC(S0859);S0859, >98%;S0859 >=98% (HPLC);S 0859; S-0859; S 0859; S-0859;(4S)-4-HYDROXY-4-[(3R)-3-HYDROXYBUTYL]-3,5,5-TRIMETHYL-2-CYCLOHEXEN-1-ONE;2-chloro-N-((2'-(N-cyanosulfamoyl)biphenyl-4-yl)methyl)-N-(4-methylbenzyl)benzamide;2-Chloro-N-((2'-(N-cyanosulfamoyl)-[1,1'-biphenyl]-4-yl)methyl)-N-(4-methylbenzyl)benzamide

CBNumber:: CB32642793

Molecular Formula:: C29H24ClN3O3S

Molecular Weight:: 530.04

MDL Number:: MFCD23136018

MOL File:: 1019331-10-2.mol

MSDS File:: SDS

Last updated:2024-11-19 23:02:33

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S0859 Properties

Boiling point	748.5±70.0 °C(Predicted)
Density	1.313±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: soluble10mg/mL, clear
form	powder
pka	-1.34±0.40(Predicted)
color	white to light brown

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P280-P305+P351+P338
WGK Germany	3

S0859 price More Price(23)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML0638	S0859 ≥98% (HPLC)	1019331-10-2	5mg	$123	2024-03-01	Buy
Sigma-Aldrich	SML0638	S0859 ≥98% (HPLC)	1019331-10-2	25mg	$496	2024-03-01	Buy
Cayman Chemical	18497	S0859 ≥95%	1019331-10-2	1mg	$32	2024-03-01	Buy
Cayman Chemical	18497	S0859 ≥95%	1019331-10-2	5mg	$86	2024-03-01	Buy
Cayman Chemical	18497	S0859 ≥95%	1019331-10-2	10mg	$153	2024-03-01	Buy

Product number	Packaging	Price	Buy
SML0638	5mg	$123	Buy
SML0638	25mg	$496	Buy
18497	1mg	$32	Buy
18497	5mg	$86	Buy
18497	10mg	$153	Buy

S0859 Chemical Properties,Uses,Production

Uses

2-Chloro-N-[[2'-[(cyanoamino)sulfonyl][1,1'-biphenyl]-4-yl]methyl]-N-[(4-methylphenyl)methyl]benzamide is a selective inhibitor of sodium-bicarbonate cotransporters in mammalian heart.

Description

S0859 is an N-cyanosulphonamide that blocks the sodium/bicarbonate cotransporter (NBC, also known as SLC4A7), which regulates intracellular pH, particularly in myocytes. It inhibits intracellular pH recovery in myocytes with a K_i value of 1.7 μM, with full inhibition occurring at ~30 μM. S0859 does not affect other exchange proteins or enzymes that might regulate intracellular pH. It prevents changes in pH associated with depolarization and hyperpolarization of ventricular myocytes from rabbit, rat, and guinea pig. S0859 has also been used to study the role of NBC in coronary endothelial cells, cancer cells, embryonic kidney cells, and neutrophils.

Uses

2-Chloro-N-[[2''-[(cyanoamino)sulfonyl][1,1''-biphenyl]-4-yl]methyl]-N-[(4-methylphenyl)methyl]benzamide is a selective inhibitor of sodium-bicarbonate cotransporters in mammalian heart.

Biochem/physiol Actions

S0859 is a selective high-affinity generic inhibitor of the Na+/HCO3- sodium bicarbonate co-transporter (NBC). S0859 does not inhibit Na+-H+ exchange (NHE).

S0859 Preparation Products And Raw materials

Raw materials

Preparation Products

S0859 Suppliers

Global( 96)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32956	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29880	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6312	58
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	eric@witopchemical.com	China	23541	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10473	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
Coresyn Pharmatech Co., Ltd.	+86-571-86626709 +86-18157142896	cbc@coresyn.com	China	9984	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
Hebei Miaoyin Technology Co.,Ltd	+86-17367732028 +86-17367732028	kathy@hbyinsheng.com	China	3512	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
TargetMol Chemicals Inc.	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
ANHUI WITOP BIOTECH CO., LTD	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
Coresyn Pharmatech Co., Ltd.	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58
Hebei Miaoyin Technology Co.,Ltd	58

View Lastest Price from S0859 manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-11-19	S0859 1019331-10-2	US $33.00-89.00 / mg		99.53%	10g	TargetMol Chemicals Inc.
2022-02-18	S0859 1019331-10-2	US $0.00 / gram	1gram	99%	10kg	Zhejiang J&C Biological Technology Co.,Limited
2019-09-06	1H-Isoindole-1,3(2H)-dione, 5-[5-[[3-(4-broMophenyl)-2-iMino-4-oxo-5-thiazolidinylidene]Methyl]-2-furanyl]- 1019331-10-2	US $1.00 / KG	1KG	98%	20kg	Career Henan Chemical Co

S0859
1019331-10-2
US $33.00-89.00 / mg
99.53%
TargetMol Chemicals Inc.

S0859
1019331-10-2
US $0.00 / gram
99%
Zhejiang J&C Biological Technology Co.,Limited

1H-Isoindole-1,3(2H)-dione, 5-[5-[[3-(4-broMophenyl)-2-iMino-4-oxo-5-thiazolidinylidene]Methyl]-2-furanyl]-
1019331-10-2
US $1.00 / KG
98%
Career Henan Chemical Co

1019331-10-2(S0859)Related Search:

Deionized water N,N'-Ethylenebis(stearamide) (2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride

2-chloro-N-[[2'-[(cyanoamino)sulfonyl][1,1'-biphenyl]-4-yl]methyl]-N-[(4-methylphenyl)methyl]- S0859 2-Chloro-N-[[2′-[(cyanoamino)sulfonyl][1,1′-biphenyl]-4-yl]methyl]-N-[(4-methylphenyl)methyl]-benzamide 2-Chloro-N-((2'-(N-cyanosulfamoyl)-[1,1'-biphenyl]-4-yl)methyl)-N-(4-methylbenzyl)benzamide S0859 (4S)-4-HYDROXY-4-[(3R)-3-HYDROXYBUTYL]-3,5,5-TRIMETHYL-2-CYCLOHEXEN-1-ONE 100852 S 0859; S-0859; S 0859; S-0859 CS-1766 S0859, >98% Benzamide, 2-chloro-N-[[2'-[(cyanoamino)sulfonyl][1,1'-biphenyl]-4-yl]methyl]-N-[(4-methylphenyl)methyl]- S0859 >=98% (HPLC) 2-Chloro-N-({4-[2-(cyanosulfamoyl)phenyl]phenyl}methyl)-N-[(4-methylphenyl)methyl]benzamide NBC(S0859) 2-chloro-N-((2'-(N-cyanosulfamoyl)biphenyl-4-yl)methyl)-N-(4-methylbenzyl)benzamide 2-Chloro-N-((2'-(N-cyanosulfamoyl)-[1,1'-biphenyl]-4-yl)methyl)-N-(4-methylbenzyl)benzamide 1019331-10-2 Inhibitors APIs