PST2744 (hydrochloride)
- CAS No.
- 374559-48-5
- Chemical Name:
- PST2744 (hydrochloride)
- Synonyms
- PST2774;PST-2774;PST2744 (hydrochloride);PST-2744 (hydrochloride);PST 2744 (hydrochloride);IstaroxiMe (hydrochloride);Istaroxime hydrochloride, >=98%;Istaroxime hydrochloride(PST2744);(5alpha)-Androstane-3,6,17-trione 3-[O-(2-aminoethyl)oxime] monohydrochloride
- CBNumber:
- CB32666641
- Molecular Formula:
- C21H33ClN2O3
- Molecular Weight:
- 396.96
- MDL Number:
- MOL File:
- 374559-48-5.mol
| storage temp. | Store at -20°C |
|---|---|
| solubility | Soluble in DMSO |
| form | Powder |
| color | White to light brown |
| FDA UNII | N24U08609A |
PST2744 (hydrochloride) price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-1623 | Istaroxime(hydrochloride) 99.32% | 374559-48-5 | 5mg | $278 | 2021-12-16 | Buy |
| ApexBio Technology | A3508 | Istaroximehydrochloride | 374559-48-5 | 5mg | $340 | 2021-12-16 | Buy |
| ChemScene | CS-1623 | Istaroxime(hydrochloride) 99.32% | 374559-48-5 | 10mg | $426 | 2021-12-16 | Buy |
| ApexBio Technology | A3508 | Istaroximehydrochloride | 374559-48-5 | 10mg | $520 | 2021-12-16 | Buy |
| ApexBio Technology | A3508 | Istaroximehydrochloride | 374559-48-5 | 2mg | $227 | 2021-12-16 | Buy |
PST2744 (hydrochloride) Chemical Properties,Uses,Production
Biological Activity
istaroxime hydrochloride(pst2744) is a novel inhibitor of na+/k+-atpase with ic50 value of 0.43±0.15μm [1].istaroxime is a steroidal drug unrelated to cardiac glycosides that improves cellular calcium cycling. the inhibition of na+/k+-atpase induces cytosolic calcium accumulation during systole (inotropism). clinical studies has been done with istaroxime in phase ii. istaroxime could be a promising alternative for patients with acute heart failure syndrome for whom the therapeutic options are currently limited [2].
in vitro
studies show that istaroxime can inhibit the activity of na+/k+-atpase from dog kidney without significant interaction with other several receptors. it demonstrates the selectivity of istaroxime. ex vivo studies show the inotropic effect can be achieved up to 60% for istaroxime. istaroxime can also increase the force of contraction of guinea pig paced left atria in the range 0.3 to 30μm. in vivo assays prove istaroxime is consistently safer than digoxin [1].
target
Na+/K+ ATPase
References
[1] r. micheletti, g. g. mattera, m. rocchetti, a. schiavone, m. f. loi, a. zaza, r. j. p. gagnol, s. de munari, p. melloni, p. carminati, g. bianchi, and p. ferrari. pharmacological profile of the novel inotropic agent (e,z)-3-((2-aminoethoxy)imino)androstane-6,17-dione hydrochloride (pst2744). the journal of pharmacology and experimental therapeutics. 2002, 303 (2): 592-600.
[2] suruchi aditya, aditya rattan. istaroxime: a rising star in acute heart failure. journal of pharmacology and pharmacotherapeutics. 2012, 3(4): 353-355.
PST2744 (hydrochloride) Preparation Products And Raw materials
Raw materials
Preparation Products
PST2744 (hydrochloride) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 | gksales1@gk-bio.com | China | 9322 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7553 | 61 |
| LETOPHARM LIMITED | +86-21-5821 5861 | sales@letopharm.com | China | 2384 | 58 |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9254 | 55 | |
| Guangzhou QiYun Biotechnology Co., Ltd. | 020-61288194 61288195 | 505721671@qq.com | China | 3868 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 27314 | 60 |
| Lancrix Chemicals | 86-21-50817262 | sales@lancrix.com | China | 1503 | 55 |
View Lastest Price from PST2744 (hydrochloride) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-13 | Istaroxime hydrochloride
374559-48-5
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2021-07-10 | Istaroxime hydrochloride
374559-48-5
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- Istaroxime hydrochloride
374559-48-5
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- Istaroxime hydrochloride
374559-48-5
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd