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XL-388

XL-388 Structure
XL-388 structure
CAS No.
1251156-08-7
Chemical Name:
XL-388
Synonyms
XL388;CS-772;XL-388;XL 388;XL388, >=98%;XL-388;XL 388;XL-388 USP/EP/BP;XL388, 10 mM in DMSO;Carbamazepine 298-46-4 three units, HPLC Purity : XL388;inhibit,XL388,XL 388,Mammalian target of Rapamycin,Inhibitor,mTOR,XL-388
CBNumber:
CB32666702
Molecular Formula:
C23H22FN3O4S
Molecular Weight:
455.5
MDL Number:
MFCD24386875
MOL File:
1251156-08-7.mol
Last updated:2025-01-27 09:38:02
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XL-388 Properties

Melting point >188oC (dec.)
Boiling point 738.6±60.0 °C(Predicted)
Density 1.354±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility DMSO (Slightly), Methanol (Slightly)
pka 6.22±0.13(Predicted)
form Solid
color Off-White to Pale Yellow
Stability Hygroscopic
FDA UNII B7I5G3Z7XR
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
NFPA 704
0
2 0

XL-388 price More Price(34)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML1239 XL388 ≥98% (HPLC) 1251156-08-7 5MG $58.4 2024-03-01 Buy
Cayman Chemical 20237 XL388 ≥98% 1251156-08-7 5mg $121 2024-03-01 Buy
Cayman Chemical 20237 XL388 ≥98% 1251156-08-7 10mg $230 2024-03-01 Buy
Cayman Chemical 20237 XL388 ≥98% 1251156-08-7 25mg $505 2024-03-01 Buy
Cayman Chemical 20237 XL388 ≥98% 1251156-08-7 50mg $903 2024-03-01 Buy
Product number Packaging Price Buy
SML1239 5MG $58.4 Buy
20237 5mg $121 Buy
20237 10mg $230 Buy
20237 25mg $505 Buy
20237 50mg $903 Buy

XL-388 Chemical Properties,Uses,Production

Uses

XL388 is a highly potent, orally bioavailable, selective, ATP-competitive mammalian target of rapamycin (mTOR) inhibitor. XL388 has shown significant and dose-dependent antitumor activity in athymic nude mice implanted with human tumor xenografts.

Biological Activity

XL388 is a potent, selective, orally bioavailable ATP-competitive inhibitor of mammalian target of rapamycin (mTOR) with an IC50 of 9.9 nM for mTOR, 8 nM for mTORC1, 166 nM for mTORC2, and 1000-fold selectivity for mTOR over the closely related PI3K kinases and a panel of 141 protein kinases tested. XL388 blocked mTORC1 phosphorylation of p70S6K (T389) with an IC50 value of 94 nM and blocked mTORC2 phosphorylationof AKT (S473) with an IC50 value of 350 nM. XL388 showed complete tumor growth inhibition in mice bearing MCF-7 xenograft tumors.

XL-388 Preparation Products And Raw materials

Raw materials

Preparation Products

XL-388 Suppliers

Global( 97)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32965 60
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30233 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 22787 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38631 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525 masar@topule.com China 8467 58
LEAPCHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 43340 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
TargetMol Chemicals Inc. 		58
Career Henan Chemica Co 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
Dideu Industries Group Limited 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
InvivoChem 		58
TargetMol Chemicals Inc. 		58
Wuhan Topule Biopharmaceutical Co., Ltd 		58
LEAPCHEM CO., LTD. 		58

View Lastest Price from XL-388 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
XL388 pictures 2024-11-19 XL388
1251156-08-7
 US $38.00-89.00 / mg 99.53% 10g TargetMol Chemicals Inc.
  • XL388 pictures
  • XL388
    1251156-08-7
  • US $38.00-89.00 / mg
  • 99.53%
  • TargetMol Chemicals Inc.

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Methanone, [7-(6-amino-3-pyridinyl)-2,3-dihydro-1,4-benzoxazepin-4(5H)-yl][3-fluoro-2-methyl-4-(methylsulfonyl)phenyl]- [7-(6-Amino-3-pyridinyl)-2,3-dihydro-1,4-benzoxazepin-4(5H)-yl][3-fluoro-2-methyl-4-(methylsulfonyl)phenyl]-methanone XL388 XL388, >=98% (7-(6-Aminopyridin-3-yl)-2,3-dihydrobenzo[f][1,4]oxazepin-4(5H)-yl)(3-fluoro-2-methyl-4-(methy XL 388 XL-388 [7-(6-Amino-3-pyridinyl)-2,3-dihydro-1,4-benzoxazepin-4(5H)-yl][3-fluoro-2-methyl-4-(methylsulfonyl)phenyl]-methanone Carbamazepine 298-46-4 three units, HPLC Purity : XL388 XL-388;XL 388 CS-772 XL-388 USP/EP/BP (7-(6-Aminopyridin-3-yl)-2,3-dihydrobenzo[f][1,4]oxazepin-4(5H)-yl)(3-fluoro-2-methyl-4-(methylsulfonyl)phenyl)methanone XL388 inhibit,XL388,XL 388,Mammalian target of Rapamycin,Inhibitor,mTOR,XL-388 XL388, 10 mM in DMSO 1251156-08-7 PI3K/Akt/mTOR Akt mTOR PI3K Inhibitors