TMC-647055
- CAS No.
- 1204416-97-6
- Chemical Name:
- TMC-647055
- Synonyms
- CS-1838;TMC647055;MTC647055;TMC 647055;TMC-647055;11BD024G7J;AGN-PC-078RUU;CHEMBL2043025;SureCN1239667;TMC647055; AGN-PC-078RUU; SURECN1239667; CHEMBL2043025; 11BD024G7J; TMC 647055
- CBNumber:
- CB32667446
- Molecular Formula:
- C32H38N4O6S
- Molecular Weight:
- 606.73
- MDL Number:
- MOL File:
- 1204416-97-6.mol
- MSDS File:
- SDS
| Density | 1.38±0.1 g/cm3(Predicted) |
|---|---|
| storage temp. | Store at -20°C |
| solubility | insoluble in H2O; insoluble in EtOH; ≥72.8 mg/mL in DMSO with gentle warming |
| form | solid |
| pka | 5.14±0.20(Predicted) |
| FDA UNII | 11BD024G7J |
TMC-647055 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ApexBio Technology | B5822 | TMC647055Cholinesalt | 1204416-97-6 | 5mg | $300 | 2021-12-16 | Buy |
| ApexBio Technology | B5822 | TMC647055Cholinesalt | 1204416-97-6 | 25mg | $900 | 2021-12-16 | Buy |
| DC Chemicals | DC7872 | TMC647055 >98% | 1204416-97-6 | 100mg | $1000 | 2021-12-16 | Buy |
| DC Chemicals | DC7872 | TMC647055 >98% | 1204416-97-6 | 250mg | $1800 | 2021-12-16 | Buy |
| DC Chemicals | DC7872 | TMC647055 >98% | 1204416-97-6 | 1g | $3600 | 2021-12-16 | Buy |
TMC-647055 Chemical Properties,Uses,Production
Biological Activity
tmc647055 is a potent and selective non-nucleoside inhibitor of the hepatitis c virus ns5b polymerase with ec50 value of 82 nm [1].hepatitis c virus (hcv) ns5b polymerase is a rna-dependant rna-polymerase that is responsible for viral replication and plays an important role in hcv life cycle. hcv is a major cause of chronic liver disease and acute hepatitis, ultimately leading to liver failure, cirrhosis and hepatocellular carcinoma [1].tmc647055 is a selective and cell-permeating hcv ns5b inhibitor. in rna polymerase primer-dependent transcription assay, tmc647055 inhibited hcv ns5b polymerase with ic50 value of 34 nm. in the huh7-luc cell line, tmc647055 inhibited the replication of genotype 1b replicon with ec50 values of 77 and 139 nm measured with luciferase readout and qrt-pcr readout, respectively. tmc647055 exhibited high-affinity interaction with ns5b across all genotypes (except for genotype 2b) with median kd value < 35 nm. in huh7-luc replicon cells, tmc647055 (750 nm) reduced 30 cell colonies formation. also, tmc647055 (1.5 μm and 3.75 μm) reduced hcv replicon rna [2] [3].
References
[1]. vendeville s, lin ti, hu l, et al. finger loop inhibitors of the hcv ns5b polymerase. part ii. optimization of tetracyclic indole-based macrocycle leading to the discovery of tmc647055. bioorg med chem lett, 2012, 22(13): 4437-4443.
[2]. devogelaere b, berke jm, vijgen l, et al. tmc647055, a potent nonnucleoside hepatitis c virus ns5b polymerase inhibitor with cross-genotypic coverage. antimicrob agents chemother, 2012, 56(9): 4676-4684.
[3]. cummings md, lin ti, hu l, et al. discovery and early development of tmc647055, a non-nucleoside inhibitor of the hepatitis c virus ns5b polymerase. j med chem, 2014, 57(5): 1880-1892.
TMC-647055 Preparation Products And Raw materials
Raw materials
Preparation Products
TMC-647055 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10522 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2923 | 55 | |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7887 | 56 |
| LETOPHARM LIMITED | +86-21-5821 5861 | sales@letopharm.com | China | 2384 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4287 | 55 | |
| Shanghaizehan biopharma technology co., Ltd. | 021-61350663 13052117465 | sales@zehanbiopharma.com | China | 998 | 55 |
| Hui Chem Co., Ltd. | 021-34799779 18918539052 | 1879902218@qq.com | China | 77 | 55 |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9254 | 55 |