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TMC-647055

CAS No.
1204416-97-6
Chemical Name:
TMC-647055
Synonyms
CS-1838;TMC647055;MTC647055;TMC 647055;TMC-647055;11BD024G7J;AGN-PC-078RUU;CHEMBL2043025;SureCN1239667;TMC647055; AGN-PC-078RUU; SURECN1239667; CHEMBL2043025; 11BD024G7J; TMC 647055
CBNumber:
CB32667446
Molecular Formula:
C32H38N4O6S
Molecular Weight:
606.73
MDL Number:
MOL File:
1204416-97-6.mol
MSDS File:
SDS
Last updated:2023-05-21 10:59:17

TMC-647055 Properties

Density 1.38±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility insoluble in H2O; insoluble in EtOH; ≥72.8 mg/mL in DMSO with gentle warming
form solid
pka 5.14±0.20(Predicted)
FDA UNII 11BD024G7J

TMC-647055 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ApexBio Technology B5822 TMC647055Cholinesalt 1204416-97-6 5mg $300 2021-12-16 Buy
ApexBio Technology B5822 TMC647055Cholinesalt 1204416-97-6 25mg $900 2021-12-16 Buy
DC Chemicals DC7872 TMC647055 >98% 1204416-97-6 100mg $1000 2021-12-16 Buy
DC Chemicals DC7872 TMC647055 >98% 1204416-97-6 250mg $1800 2021-12-16 Buy
DC Chemicals DC7872 TMC647055 >98% 1204416-97-6 1g $3600 2021-12-16 Buy
Product number Packaging Price Buy
B5822 5mg $300 Buy
B5822 25mg $900 Buy
DC7872 100mg $1000 Buy
DC7872 250mg $1800 Buy
DC7872 1g $3600 Buy

TMC-647055 Chemical Properties,Uses,Production

Biological Activity

tmc647055 is a potent and selective non-nucleoside inhibitor of the hepatitis c virus ns5b polymerase with ec50 value of 82 nm [1].hepatitis c virus (hcv) ns5b polymerase is a rna-dependant rna-polymerase that is responsible for viral replication and plays an important role in hcv life cycle. hcv is a major cause of chronic liver disease and acute hepatitis, ultimately leading to liver failure, cirrhosis and hepatocellular carcinoma [1].tmc647055 is a selective and cell-permeating hcv ns5b inhibitor. in rna polymerase primer-dependent transcription assay, tmc647055 inhibited hcv ns5b polymerase with ic50 value of 34 nm. in the huh7-luc cell line, tmc647055 inhibited the replication of genotype 1b replicon with ec50 values of 77 and 139 nm measured with luciferase readout and qrt-pcr readout, respectively. tmc647055 exhibited high-affinity interaction with ns5b across all genotypes (except for genotype 2b) with median kd value < 35 nm. in huh7-luc replicon cells, tmc647055 (750 nm) reduced 30 cell colonies formation. also, tmc647055 (1.5 μm and 3.75 μm) reduced hcv replicon rna [2] [3].

References

[1]. vendeville s, lin ti, hu l, et al. finger loop inhibitors of the hcv ns5b polymerase. part ii. optimization of tetracyclic indole-based macrocycle leading to the discovery of tmc647055. bioorg med chem lett, 2012, 22(13): 4437-4443.
[2]. devogelaere b, berke jm, vijgen l, et al. tmc647055, a potent nonnucleoside hepatitis c virus ns5b polymerase inhibitor with cross-genotypic coverage. antimicrob agents chemother, 2012, 56(9): 4676-4684.
[3]. cummings md, lin ti, hu l, et al. discovery and early development of tmc647055, a non-nucleoside inhibitor of the hepatitis c virus ns5b polymerase. j med chem, 2014, 57(5): 1880-1892.

TMC-647055 Preparation Products And Raw materials

Raw materials

Preparation Products

TMC-647055 Suppliers

Global( 42)Suppliers
Supplier Tel Email Country ProdList Advantage
Zhejiang J&C Biological Technology Co.,Limited
+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
InvivoChem
+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
Amadis Chemical Company Limited
571-89925085 sales@amadischem.com China 131957 58
Shanghai Boyle Chemical Co., Ltd. sales@boylechem.com China 2922 55
Sichuan Wei Keqi Biological Technology Co., Ltd. 028-81700200 18116577057 3003855609@qq.com China 7887 56
LETOPHARM LIMITED +86-21-5821 5861 sales@letopharm.com China 2384 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696,15000506266 15000506266 China 4512 55
Shanghaizehan biopharma technology co., Ltd. 021-61350663 13052117465 sales@zehanbiopharma.com China 1009 55
Hui Chem Co., Ltd. 021-34799779 18918539052 1879902218@qq.com China 77 55
SPIRO PHARMA eric_feng1954@126.com China 9248 55

TMC-647055 Spectrum

TMC 647055 TMC647055 TMC-647055 2,19-methano-3,7:4,1-dimetheno-1H,11H-14,10,2,9,11,17-benzoxathiatetraazacyclodocosine-8,18(9H,15H)-dione 27-Cyclohexyl-12,13,16,17-tetrahydro-22-methoxy-11,17-dimethyl-2,19-methano-3,7:4,1-dimetheno-1H,11H-14,10,2,9,11,17-benzoxathiatetraazacyclodocosine-8,18(9H,15H)-dione 10,10-dioxide 2,19-Methano-3,7:4,1-dimetheno-1H,11H-14,10,2,9,11,17-benzoxathiatetraazacyclodocosine-8,18(9H,15H)-dione, 27-cyclohexyl-12,13,16,17-tetrahydro-22-methoxy-11,17-dimethyl-, 10,10-dioxide SureCN1239667 CHEMBL2043025 AGN-PC-078RUU 11BD024G7J TMC647055; AGN-PC-078RUU; SURECN1239667; CHEMBL2043025; 11BD024G7J; TMC 647055 CS-1838 MTC647055 1204416-97-6 C32H38N4O6S C37H53N5O8S