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ChemicalBook >> CAS DataBase List >>N-(4-chloropyridin-3-yl)-4-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)Methyl)piperazine-1-carboxaMide

N-(4-chloropyridin-3-yl)-4-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)Methyl)piperazine-1-carboxaMide

N-(4-chloropyridin-3-yl)-4-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)Methyl)piperazine-1-carboxaMide Structure
N-(4-chloropyridin-3-yl)-4-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)Methyl)piperazine-1-carboxaMide structure
CAS No.
1346528-50-4
Chemical Name:
N-(4-chloropyridin-3-yl)-4-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)Methyl)piperazine-1-carboxaMide
Synonyms
CS-2830;JNJ42165279;JNJ-42165279 (JNJ-5279);JNJ 42165279;JNJ42165279;Fatty acid amide hydrolase,inhibit,Autophagy,JNJ 42165279,FAAH,JNJ-42165279,Inhibitor;N-(4-Chloro-3-pyridinyl)-4-[(2,2-difluoro-1,3-benzodioxol-5-yl)methyl]-1-piperazinecarboxamide;1-Piperazinecarboxamide, N-(4-chloro-3-pyridinyl)-4-[(2,2-difluoro-1,3-benzodioxol-5-yl)methyl]-;N-(4-chloropyridin-3-yl)-4-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)Methyl)piperazine-1-carboxaMide
CBNumber:
CB32671063
Molecular Formula:
C18H17ClF2N4O3
Molecular Weight:
410.8
MDL Number:
MFCD29047142
MOL File:
1346528-50-4.mol
Last updated:2024-11-19 23:02:33
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N-(4-chloropyridin-3-yl)-4-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)Methyl)piperazine-1-carboxaMide Properties

Boiling point 541.2±50.0 °C(Predicted)
Density 1.52±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility ≤30mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide
form crystalline solid
pka 12.91±0.20(Predicted)
color White to off-white
FDA UNII AH2E5UQ11Y

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS08
Signal word  Warning
Hazard statements  H361f
NFPA 704
0
2 0

N-(4-chloropyridin-3-yl)-4-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)Methyl)piperazine-1-carboxaMide price More Price(16)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 19987 JNJ-42165279 ≥98% 1346528-50-4 1mg $44 2024-03-01 Buy
Cayman Chemical 19987 JNJ-42165279 ≥98% 1346528-50-4 5mg $172 2024-03-01 Buy
Cayman Chemical 19987 JNJ-42165279 ≥98% 1346528-50-4 10mg $257 2024-03-01 Buy
Cayman Chemical 19987 JNJ-42165279 ≥98% 1346528-50-4 25mg $479 2024-03-01 Buy
ApexBio Technology C4122 JNJ-42165279 1346528-50-4 25mg $546 2021-12-16 Buy
Product number Packaging Price Buy
19987 1mg $44 Buy
19987 5mg $172 Buy
19987 10mg $257 Buy
19987 25mg $479 Buy
C4122 25mg $546 Buy

N-(4-chloropyridin-3-yl)-4-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)Methyl)piperazine-1-carboxaMide Chemical Properties,Uses,Production

Description

JNJ-42165279 is a potent, irreversible inhibitor of fatty acid amide hydrolase (FAAH; IC50s = 70 and 313 nM for human and rat forms, respectively). It displays selectivity for FAAH over a panel of other enzymes, receptors, transporters, and ion channels. JNJ-42165279 is active in vivo, blocking FAAH activity in brain and periphery of rats and raising concentrations of anandamide , oleoyl ethanolamide , and palmitoyl ethanolamide . It is also efficacious in the spinal nerve ligation model of neuropathic pain.

in vitro

jnj-42165279 inhibited recombinant human and rat faah with the ic50s of 70 ± 8 nm and 313 ± 28 nm, respectively [1]. jnj-42165279 (10 μm) exhibited high selectivity against a panel of receptors, enzymes, transporters, and ion-channels. jnj-42165279 (10 μm) showed no inhibitory effects against cyps (1a2, 2c8, 2c9, 2c19, 2d6, 3a4) or herg [1].

in vivo

in the rat spinal nerve ligation (snl or chung) model of neuropathic pain, jnj-42165279 exhibited analgesic properties. jnj-42165279 dose-dependently reversed the robust tactile allodynia. the ed90 was 22 mg/kg, which corresponds to a plasma concentration of 2.5 μm at 30 min [1].

References

[1] keith j m, jones w m, tichenor m, et al. preclinical characterization of the faah inhibitor jnj-42165279[j]. acs medicinal chemistry letters, 2015, 6(12): 1204-1208.

N-(4-chloropyridin-3-yl)-4-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)Methyl)piperazine-1-carboxaMide Preparation Products And Raw materials

Raw materials

Preparation Products

N-(4-chloropyridin-3-yl)-4-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)Methyl)piperazine-1-carboxaMide Suppliers

Global( 64)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32957 60
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
TopScience Biochemical 		00852-68527855 info@itopbiochem.com China Hong Kong 902 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29811 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32165 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
LEAP CHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 24727 58
Nantong HI-FUTURE Biology Co., Ltd. 		+undefined18051384581 sales@chemhifuture.com China 3135 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38632 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
BOC Sciences 		58
TopScience Biochemical 		58
career henan chemical co 		58
TargetMol Chemicals Inc. 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
InvivoChem 		58
LEAP CHEM CO., LTD. 		58
Nantong HI-FUTURE Biology Co., Ltd. 		58
TargetMol Chemicals Inc. 		58

View Lastest Price from N-(4-chloropyridin-3-yl)-4-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)Methyl)piperazine-1-carboxaMide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
JNJ-42165279 pictures 2024-11-19 JNJ-42165279
1346528-50-4
 US $38.00-88.00 / mg 99.91% 10g TargetMol Chemicals Inc.
N-(4-chloropyridin-3-yl)-4-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)Methyl)piperazine-1-carboxaMide pictures 2020-02-06 N-(4-chloropyridin-3-yl)-4-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)Methyl)piperazine-1-carboxaMide
1346528-50-4
 US $3.00 / KG 1KG 98% 100KG Career Henan Chemical Co
  • JNJ-42165279 pictures
  • JNJ-42165279
    1346528-50-4
  • US $38.00-88.00 / mg
  • 99.91%
  • TargetMol Chemicals Inc.

1346528-50-4(N-(4-chloropyridin-3-yl)-4-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)Methyl)piperazine-1-carboxaMide)Related Search:

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N-(4-chloropyridin-3-yl)-4-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)Methyl)piperazine-1-carboxaMide N-(4-Chloro-3-pyridinyl)-4-[(2,2-difluoro-1,3-benzodioxol-5-yl)methyl]-1-piperazinecarboxamide JNJ42165279 CS-2830 JNJ 42165279;JNJ42165279 1-Piperazinecarboxamide, N-(4-chloro-3-pyridinyl)-4-[(2,2-difluoro-1,3-benzodioxol-5-yl)methyl]- JNJ-42165279 (JNJ-5279) Fatty acid amide hydrolase,inhibit,Autophagy,JNJ 42165279,FAAH,JNJ-42165279,Inhibitor 1346528-50-4 1356528-50-4 C18H17ClF2N4O3