LLL12
- CAS No.
- 1260247-42-4
- Chemical Name:
- LLL12
- Synonyms
- LLL12;LLL-12 (LLL12;5-hydroxy-9,10-dioxo-9,10-dihydroanthracene-1-sulfonamide;1-Anthracenesulfonamide, 9,10-dihydro-5-hydroxy-9,10-dioxo-
- CBNumber:
- CB32731095
- Molecular Formula:
- C14H9NO5S
- Molecular Weight:
- 303.29
- MDL Number:
- MOL File:
- 1260247-42-4.mol
LLL12 Chemical Properties,Uses,Production
Description
LLL12 is a potent STAT3 inhibitor. LLL12 inhibits colony formation and cell migration and works synergistically with doxorubicin and gemcitabine. LLL12 demonstrated a potent inhibitory activity on breast and glioblastoma tumor growth in a mouse xenograft model. LLL12 may be a potential therapeutic agent for human cancer cells expressing constitutive STAT3 signaling.
Uses
LLL12 is a small molecule inhibitor of STAT3 that inhibits STAT3 phosphorylation. LLL12 enhanced the inhibitory effect of Cisplatin (HY-17394) and Paclitaxel (HY-B0015) on ovarian cancer cell formation, migration, and growth[1].
in vivo
LLL12 (5 mg/kg; i.p.; once daily for 13 d) shows strong growth inhibition activity in mouse osteosarcoma cells and tumor growth[2].
| Animal Model: | Mouse xenografts with SJSA or OS-33 osteosarcoma cells[2] |
| Dosage: | 5 mg/kg |
| Administration: | Intraperitoneal injection; once daily for 13 days |
| Result: | Resulted in a significant reduction in tumor volume and tumor mass in the OS-33 and SJSA xenografted mice. |
IC 50
p-STAT3
References
[1] Zhang R, et al. A small molecule STAT3 inhibitor, LLL12, enhances cisplatin? and paclitaxel?mediated inhibition of cell growth and migration in human ovarian cancer cells. Oncol Rep. 2020 Sep;44(3):1224-1232. DOI:10.3892/or.2020.7667
[2] Onimoe GI, et al. Small molecules, LLL12 and FLLL32, inhibit STAT3 and exhibit potent growth suppressive activity in osteosarcoma cells and tumor growth in mice. Invest New Drugs. 2012 Jun;30(3):916-26. DOI:10.1007/s10637-011-9645-1
LLL12 Preparation Products And Raw materials
Raw materials
Preparation Products
LLL12 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| TargetMol Chemicals Inc. | +8613564774135 | zijue.cai@tsbiochem.com | United States | 19881 | 58 |
| SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD | 13816107857 | sales@fortunechem-sh.com | China | 825 | 58 |
| Suzhou yacoo science co.,Ltd | 0512-87182056 18013166090 | lingling.qi@yacoo.com.cn | China | 7295 | 60 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24641 | 58 |
| Chengdu Peter-like Biotechnology Co., Ltd. | 028-81700200 13308200041 | 2851167782@qq.com | China | 11183 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 15850508050 | cindy.huang@synzest.com | China | 12000 | 58 |
