[[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato]]] copper
![[[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato]]] copper Structure](CAS/20180808/GIF/68341-09-3.gif)
- CAS No.
- 68341-09-3
- Chemical Name:
- [[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato]]] copper
- Synonyms
- CUAM;Cu-ASTM;Cu-ATSM;CuII(atsm);Cu-ASTM >=98% (HPLC);Diacetylbis(N(4)-methylthiosemicarbazonato) copper(II);[[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato]]] copper
- CBNumber:
- CB32750504
- Molecular Formula:
- C8H14CuN6S2
- Molecular Weight:
- 321.91296
- MDL Number:
- MFCD20275141
- MOL File:
- 68341-09-3.mol
| storage temp. | 2-8°C |
|---|---|
| solubility | DMSO: soluble10mg/mL, clear |
| form | powder |
| color | brown to dark red-brown |
| FDA UNII | 0YDK1H9L3A |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
[[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato]]] copper price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0769 | Cu-ASTM ≥98% (HPLC) | 68341-09-3 | 5mg | $123 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0769 | Cu-ASTM ≥98% (HPLC) | 68341-09-3 | 25mg | $482 | 2024-03-01 | Buy |
| Cayman Chemical | 17122 | Cu-ATSM ≥95% | 68341-09-3 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 17122 | Cu-ATSM ≥95% | 68341-09-3 | 5mg | $93 | 2024-03-01 | Buy |
| Cayman Chemical | 17122 | Cu-ATSM ≥95% | 68341-09-3 | 10mg | $169 | 2024-03-01 | Buy |
[[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato]]] copper Chemical Properties,Uses,Production
Uses
Cu-ATSM is preclinically used as a potential therapy for ALS (amyotrophic lateral sclerosis). A potential anti-Alzheimer''s agent.
Biochem/physiol Actions
Cu-ATSM is an orally bioavailable, blood-brain barrier permeable complex that specifically inhibits the action of peroxynitrite on Cu,Zn superoxide dismutase (SOD1) and subsequent nitration of cellular proteins. CuII(ATSM) significantly delayed onset of disease (paralysis and prolonged lifespan) in amyotrophic lateral sclerosis (ALS) mice model. Also, Cu-ATSM was reported to lower lipid peroxidation in a model of ischemicreperfusion injury. Cu-ATSM subsequently was shown to inhibit ferroptosis with a potency similar to Liproxstatin-1.
in vivo
CuATSM (1.5 mg/kg, iv, single dose) reduces cerebral infarct volume and oxidative stress, exhibits neuroprotective effect against ischemic stroke in mouse model[2].
| Animal Model: | Mouse transient middle cerebral artery occlusion (tMCAO) model[2] |
| Dosage: | 1.5 mg/kg |
| Administration: | iv, single dose |
| Result: | Reduced the expression of oxidative stress markers such as 4-HNE, 8-OHdG, and nitrotyrosine. |
[[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato]]] copper Preparation Products And Raw materials
Raw materials
Preparation Products
[[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato]]] copper Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21622 | 55 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38755 | 58 | |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| YangZhou Ruihong Biotech Co., Ltd. | 015380367604 15380367604 | China | 511 | 55 | |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51395 | 80 |
| Shanghai Haozhixiang Biotechnology Co., Ltd | 526763801 13301653310 | 526763801@qq.com | China | 8428 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 6688 | 55 |
| Shanghai Chaolan Chemical Technology Center | 021-QQ：65489617 15618227136 | Sales@ATKchemical.com | China | 9343 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6777 | 58 |
