ChemicalBook >> CAS DataBase List >>N1,N2-Bis[[4-(2-pyridinyl)phenyl]methyl]- 1,2-ethanediamine

N1,N2-Bis[[4-(2-pyridinyl)phenyl]methyl]- 1,2-ethanediamine

N1,N2-Bis[[4-(2-pyridinyl)phenyl]methyl]- 1,2-ethanediamine structure

CAS No.: 1507370-20-8

Chemical Name:: N1,N2-Bis[[4-(2-pyridinyl)phenyl]methyl]- 1,2-ethanediamine

Synonyms: BC-1215;BC-1215 (BC 1215;BC-1215 >=98% (HPLC);N1,N2-bis(4-(pyridin-2-yl)benzyl)ethane-1,2-diamine;N1,N2-Bis[[4-(2-pyridinyl)phenyl]methyl]- 1,2-ethanediamine;1,2-Ethanediamine, N1,N2-bis[[4-(2-pyridinyl)phenyl]methyl]-;{[4-(pyridin-2-yl)phenyl]methyl}[2-({[4-(pyridin-2-yl)phenyl]methyl}amino)ethyl]amine;Ligands for E3 Ligase,E3 ligase-recruiting Moiety,F-box protein 3 (Fbxo3),Inhibitor,inhibit,inflammation,MLE cells,BC 1215,PBMC cells,BC-1215,BC1215,U937 cells,TRAF

CBNumber:: CB32750524

Molecular Formula:: C26H26N4

Molecular Weight:: 394.51

MDL Number:

MOL File:: 1507370-20-8.mol

Last updated:2024-11-19 23:02:33

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N1,N2-Bis[[4-(2-pyridinyl)phenyl]methyl]- 1,2-ethanediamine Properties

Boiling point	589.9±50.0 °C(Predicted)
Density	1.125±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,2-8°C
solubility	DMSO: soluble2mg/mL, clear (warmed)
pka	9.05±0.20(Predicted)
form	A crystalline solid
color	white to beige
InChI	InChI=1S/C26H26N4/c1-3-15-29-25(5-1)23-11-7-21(8-12-23)19-27-17-18-28-20-22-9-13-24(14-10-22)26-6-2-4-16-30-26/h1-16,27-28H,17-20H2
InChIKey	IXEPQJQQSLMESJ-UHFFFAOYSA-N
SMILES	C(NCC1=CC=C(C2=NC=CC=C2)C=C1)CNCC1=CC=C(C2=NC=CC=C2)C=C1

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P305+P351+P338

Hazard Codes

Risk Statements

NFPA 704

	0
2		0

N1,N2-Bis[[4-(2-pyridinyl)phenyl]methyl]- 1,2-ethanediamine price More Price(24)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	21964	BC-1215 ≥98%	1507370-20-8	1mg	$40	2024-03-01	Buy
Cayman Chemical	21964	BC-1215 ≥98%	1507370-20-8	5mg	$138	2024-03-01	Buy
Cayman Chemical	21964	BC-1215 ≥98%	1507370-20-8	10mg	$216	2024-03-01	Buy
Cayman Chemical	21964	BC-1215 ≥98%	1507370-20-8	25mg	$486	2024-03-01	Buy
AK Scientific	0448DW	N,N'-Bis[(4-pyridin-2-ylphenyl)methyl]ethane-1,2-diamine	1507370-20-8	25mg	$606	2021-12-16	Buy

Product number	Packaging	Price	Buy
21964	1mg	$40	Buy
21964	5mg	$138	Buy
21964	10mg	$216	Buy
21964	25mg	$486	Buy
0448DW	25mg	$606	Buy

N1,N2-Bis[[4-(2-pyridinyl)phenyl]methyl]- 1,2-ethanediamine Chemical Properties,Uses,Production

Description

BC-1215 (N1,N2-Bis[[4-(2-pyridinyl)phenyl]methyl]- 1,2-ethanediamine) is an inhibitor of F-box protein 3 (FBXO3; IC50 = 0.9 μg/mL for Il-1β release). It decreases FBXO3 interaction with F-box/LRR-repeat protein 2 (FBXL2) in a dose-dependent manner and prevents FBXO3-dependent ubiquitination of FBXL2. It also lowers expression of Tnf receptor-associated factors (TRAFs) 1-6 without affecting TRAF1-6 mRNA levels in resting and LPS-stimulated peripheral blood mononuclear cells (PBMCs). BC-1215 (100 μg, i.p., per animal) reduces plasma levels of the inflammatory cytokines Il-6, Tnf, and Il-1β and decreases peritoneal bacteria counts in a mouse model of cecal ligation and puncture-induced sepsis. It also reduces inflammation in mouse models of DSS-induced colitis, paw edema, and ear edema.

N1,N2-Bis[[4-(2-pyridinyl)phenyl]methyl]- 1,2-ethanediamine Preparation Products And Raw materials

Raw materials

Preparation Products

N1,N2-Bis[[4-(2-pyridinyl)phenyl]methyl]- 1,2-ethanediamine Suppliers

Global( 59)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	+86-18341751992 +86-15382112998	757984502@qq.com	China	892	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32957	60
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6312	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49734	58
Hebei Weibang Biotechnology Co., Ltd	+8617732866630	bess@weibangbio.com	China	18152	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38631	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8467	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57505	58

Supplier	Advantage
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	58
ATK CHEMICAL COMPANY LIMITED	60
TargetMol Chemicals Inc.	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
InvivoChem	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	58
Hebei Weibang Biotechnology Co., Ltd	58
TargetMol Chemicals Inc.	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
Aladdin Scientific	58

View Lastest Price from N1,N2-Bis[[4-(2-pyridinyl)phenyl]methyl]- 1,2-ethanediamine manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-11-19	BC-1215 1507370-20-8	US $47.00-128.00 / mg		≥95%	10g	TargetMol Chemicals Inc.

BC-1215
1507370-20-8
US $47.00-128.00 / mg
≥95%
TargetMol Chemicals Inc.

BC-1215 N1,N2-Bis[[4-(2-pyridinyl)phenyl]methyl]- 1,2-ethanediamine BC-1215 (BC 1215 1,2-Ethanediamine, N1,N2-bis[[4-(2-pyridinyl)phenyl]methyl]- BC-1215 >=98% (HPLC) {[4-(pyridin-2-yl)phenyl]methyl}[2-({[4-(pyridin-2-yl)phenyl]methyl}amino)ethyl]amine N1,N2-bis(4-(pyridin-2-yl)benzyl)ethane-1,2-diamine Ligands for E3 Ligase,E3 ligase-recruiting Moiety,F-box protein 3 (Fbxo3),Inhibitor,inhibit,inflammation,MLE cells,BC 1215,PBMC cells,BC-1215,BC1215,U937 cells,TRAF 1507370-20-8