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Bisoctrizole

Bisoctrizole structure

CAS No.: 103597-45-1

Chemical Name:: Bisoctrizole

Synonyms: UV-360;Bisoctrizole;METHYLENE BIS-BENZOTRIAZOLYL TETRAMETHYLBUTYLPHENOL;MBBT;METHYLENE BIS-BENZOTRIAZOLYL TETRAMETHYLBUTYLPHENO;2,2-methylenebis(6-(2H-benzotriazol-2-yl) -4-(1,;Methylene bisbenzotriazoryl tetramethylbutyl phenol;2,2′-Methylenbis(6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol);HRsorb-360;UV360/MBBT

CBNumber:: CB3283802

Molecular Formula:: C41H50N6O2

Molecular Weight:: 658.87

MDL Number:: MFCD01103222

MOL File:: 103597-45-1.mol

MSDS File:: SDS

Last updated:2025-04-09 13:40:12

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Bisoctrizole Properties

Melting point	197-199 °C(lit.)
Boiling point	771.6±70.0 °C(Predicted)
Density	d20 1.2
vapor pressure	0Pa at 25℃
Flash point	>200°C
storage temp.	Inert atmosphere,Room Temperature
solubility	almost transparency in THF
form	Solid
pka	7.62±0.50(Predicted)
color	White to Orange to Green
Water Solubility	Insoluble < 5 ng/L at 25 °C
Merck	14,1294
BRN	11326835
Stability	Light Sensitive
InChIKey	ZRFPPIQVEQSFRV-UHFFFAOYSA-N
LogP	4.2 at 20℃
CAS DataBase Reference	103597-45-1(CAS DataBase Reference)
FDA UNII	8NT850T0YS
EPA Substance Registry System	Phenol, 2,2'-methylenebis[6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)- (103597-45-1)
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302

Precautionary statements

P280-P305+P351+P338

Risk Statements

36/37/38-53

Safety Statements

26-36/37/39-61

WGK Germany

HS Code

29339900

NFPA 704

	1
0		0

Bisoctrizole price More Price(22)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	30184	Bisoctrizole analytical standard	103597-45-1	100mg	$174	2024-03-01	Buy
Sigma-Aldrich	1075677	Bisoctrizole United States Pharmacopeia (USP) Reference Standard	103597-45-1	200mg	$436	2024-03-01	Buy
TCI Chemical	M1259	2,2'-Methylenebis[6-(benzotriazol-2-yl)-4-tert-octylphenol] >98.0%(HPLC)	103597-45-1	25g	$58	2024-03-01	Buy
TCI Chemical	M1259	2,2'-Methylenebis[6-(benzotriazol-2-yl)-4-tert-octylphenol] >98.0%(HPLC)	103597-45-1	500g	$537	2024-03-01	Buy
Sigma-Aldrich	PHR1913	Bisoctrizole Pharmaceutical Secondary Standard; Certified Reference Material	103597-45-1	500mg	$342	2024-03-01	Buy

Product number	Packaging	Price	Buy
30184	100mg	$174	Buy
1075677	200mg	$436	Buy
M1259	25g	$58	Buy
M1259	500g	$537	Buy
PHR1913	500mg	$342	Buy

Bisoctrizole Chemical Properties,Uses,Production

Chemical Properties

White powder

Chemical Properties

Wavelengths covered: about 280-400 nm, which covers both UVB and UVA ranges; peak protection at 303 nm and 358 nm.

Uses

Bisoctrizole is a light stabilizer in polymers and resins. It is majorly used as a UV filter in sunscreens and in photo-luminescent dyes for organic electronic based applications.

Definition

ChEBI: Bisoctrizole is a diarylmethane. It is a broad-spectrum organic UV filter that is marketed as Tinosorb M. It is a benzotriazole-based organic compound that absorbs, reflects, and scatters both UV-A and UV-B rays.

Application

Bisoctrizole is a non-FDA-approved combination sunscreen, but is approved in the EU and other parts of the world as a UV filter in sunscreens, day care products, and skin-whitening products at concentrations up to 10%.

brand name

Tinosorb M (Ciba Specialty Chemicals).

General Description

Bisoctrizole is a benzotriazole based additive that is used as an ultraviolet absorber (UVA). It reduces degradation of the polymeric material by absorbing the UV radiation and converting it to thermal heat. Bisoctrizole is often added to sunscreen formulations that It may protect skin against blue light and other environmental assaults.

Side effects

At present, Bisoctrizole has good safety, photostability and effectiveness, and rarely causes skin irritation. Severe allergic reactions are rare, which may be related to the fact that it is not significantly absorbed by the skin. If you experience symptoms such as difficulty breathing or swallowing, chest tightness, rash, swelling and urticaria, you need to seek medical attention immediately. Due to the lack of clinical studies on Bisoctrizole, long-term use and adverse reactions remain to be investigated.

Safety

Bisoctrizole appears to be relatively non-toxic and rarely causes skin irritation. As with many synthetic chemicals, whether bisoctrizole may produce low-level skin damage or systemic effects with long-term use is unclear. Considering that bisoctrizole is stable, poorly soluble, and minimally absorbed by the skin, the risks appear to be low. Still, more research on bisoctrizole safety is needed.

Bisoctrizole synthesis

Synthesis of Bisoctrizole from Formaldehyde and UV-329

Bisoctrizole Preparation Products And Raw materials

Raw materials

N,N,N',N'-TETRA(N-PROPYL)METHYLENEDIAMINE UV-329 Formaldehyde

Preparation Products

Bisoctrizole Suppliers

Global( 414)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Jiangxi Lotchem Co.,Ltd.	+8615270827708	lancetu@jxlotchem.com	CHINA	338	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615531151365	mina@chuanghaibio.com	China	18137	58
Watson Biotechnology Co.,Ltd	+86-18186686046 +86-18186686046	sales01@watsonbiotech.cn	China	5849	58
Shanghai Tiandui New Material Co., Ltd	+8615921093949	tianduichemical@shtiandui.com	China	48	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615531157085	abby@chuanghaibio.com	China	8808	58
Hebei Yanxi Chemical Co., Ltd.	+8617531153977	allison@yan-xi.com	China	5854	58
Wuhan Fortuna Chemical Co., Ltd	+86-027-59207850	info@fortunachem.com	China	5974	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-13131129325	sales1@chuanghaibio.com	China	5868	58
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971 +86-17331933971	deasea125996@gmail.com	China	2472	58
Hebei Kingfiner Technology Development Co.Ltd	+86-15532196582 +86-15373005021	lisa@kingfinertech.com	China	3005	58

Supplier	Advantage
Jiangxi Lotchem Co.,Ltd.	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Watson Biotechnology Co.,Ltd	58
Shanghai Tiandui New Material Co., Ltd	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Hebei Yanxi Chemical Co., Ltd.	58
Wuhan Fortuna Chemical Co., Ltd	58
Hebei Chuanghai Biotechnology Co,.LTD	58
Henan Bao Enluo International TradeCo.，LTD	58
Hebei Kingfiner Technology Development Co.Ltd	58

View Lastest Price from Bisoctrizole manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-04-25	Bisoctrizole(UV-360) 103597-45-1	US $0.00-0.00 / kg	1kg	99%	20MT	Watson Biotechnology Co.,Ltd
2025-04-25	Bisoctrizole 103597-45-1	US $79.00-38.00 / kg	1kg	99%	20ton	Hebei Zhuanglai Chemical Trading Co Ltd
2025-04-24	Ultraviolet Absorbent UV-360 103597-45-1	US $0.00 / KG	1KG	≥99%	300mt/year	Jinan Finer Chemical Co., Ltd

Bisoctrizole(UV-360)
103597-45-1
US $0.00-0.00 / kg
99%
Watson Biotechnology Co.,Ltd

Bisoctrizole
103597-45-1
US $79.00-38.00 / kg
99%
Hebei Zhuanglai Chemical Trading Co Ltd

Ultraviolet Absorbent UV-360
103597-45-1
US $0.00 / KG
≥99%
Jinan Finer Chemical Co., Ltd

Bisoctrizole Spectrum

Bisoctrizole(103597-45-1)¹HNMR Bisoctrizole(103597-45-1)IR Bisoctrizole(103597-45-1)Raman

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Methylenebisbenzotriazolyltertoctylphenol] 2,2'-Methylenebis[2-hydroxy-5-(1,1,3,3-tetramethylbutyl)-1,3-phenylene]bis(2H-benzotriazole) BIS[3-(BENZOTRIAZOL-2-YL)-2-HYDROXY-5-TERT-OCTYLPHENYL]METHANE 2,2'-METHYLENEBIS(6-(2H-BENZOTRIAZOL-2-Y L) -4-(1,1,3,3TETRAMETHYLBUTYL)PHENOL)99 ULTRAVIOLET ABSORBER UV-360 (TINUVIN360) UV ABSORBER-360 (UV360) Phenol, 2,2-methylenebis6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)- TINOSORB(R)M Bis-[2-hydroxy-5-tert-octyl-3-(benzotriazol-2-yl)-phenyl]-methane 2,2''-METHYLENEBIS[6-(BENZOTRIAZOL-2-YL)-4-TERT-OCTYLPHENOL] 98+% Ultraviolet Absorbent UV-360 bis[2-hydroxy-5-t-octyl-3-(benzotriazolyl)phenyl]methane 2,2'-Methylenebis[4-(1,1,3,3-tetramethylbutyl)-6-(2H-benzotriazol-2-yl)phenol] 2,2'-Methylenebis[4-tert-octyl-6-(2H-benzotriazole-2-yl)phenol] UV Absorber 360 Bisoctrizole (200 mg) 2,2'-Methylenebis[6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetamethylbuty)phenol] 2,2-Methylenebis[3-(2H-benzotriazol-2-yl)-5-(1,1,3,3-tetramethylbutyl)phenol],99% 2,2-Methylenebis[6-(Benzotriazol-2-yl)-4-Tert-OCLylphenol] UV-360 Ultraviolet Absorber Methylene bis[(3-(2-benzotrizolyl)-2-hydroxy-5-tert-octylphenyl] 6,6'-Methylenebis(2-(2H-benzo[d][1,2,3]triazol-2-yl)-4-(2-Methylheptan-2-yl)phenol) Samsorb UV-360 2,2'-Methylenebis[6-(benzotriazol-2-yl)-4-tert-octylphenol] HRsorb-360 2,2'-METHYLENEBIS[6-(2H-BENZOTRIAZOL-2-YL)-4-(1,1,3,3-TETRAMETHYLBUTYL)PHENOL] 2,2'-Methylenebis[6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol] Solution, 100ppm 3-(2-benzotriazolyl)-2-[[2-(2-benzotriazolyl)-6-hydroxy-4-(2,4,4-trimethylpentan-2-yl)phenyl]methyl]-5-(2,4,4-trimethylpentan-2-yl)phenol LOTSORB UV 360 UV360/MBBT Absorber UV-360 2,2'-Methylenebis[6-(benzotriazol-2-yl)-4-tert-octylphenol]> Milestab-360 UV-360 Solution in THF, 1000μg/mL Ultraviolet Absorbent UV-360 ISO 9001：2015 REACH UV ABSORBER TRUELICHT UV 360 TINUVIN 360 (UV-360) Light Stabilizer UV-Absorber RIASORB UV-360/360FF Bisoctrizole (1075677) Absorbent UV-360 2,2-methylenebis(6-(2H-benzotriazol-2-yl) -4-(1, UV-360 METHYLENE BIS-BENZOTRIAZOLYL TETRAMETHYLBUTYLPHENOL 2,2′-Methylenbis(6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol) Methylene bisbenzotriazoryl tetramethylbutyl phenol METHYLENE BIS-BENZOTRIAZOLYL TETRAMETHYLBUTYLPHENO MBBT Ultraviolet Absorbent UV-360 METHYLENE BIS-BENZOTRIAZOLYL TETRAMETHYLBUTYLPHENOL (NANO) Bisoctrizole Sinosorb? 360 Methylenebis(2-hydroxy-3-(benzotriazol-2-yl)-5-tertoctylphenyl) Dsunpro Mbbt 2,2'-Methylenebis[6-(benzotriazol-2-yl)-4-tert-octylphenol, ≥ 98.0% 2,2'-Methylenebis[6-(benzotriazol-2-yl)-4-tert-octylphenol] 6,6'-Methylenebis(2-(2H-benzo[d][1,2,3]triazol-2-yl)-4-(2,4,4-trimethylpentan-2-yl)phenol) Bisoctrizole(UV-360) 2,2'-Methylenebis[6-(benzotriazol-2-yl)-4-tert-octylphenol] in isooctane Bisoctrizole in THF