Tyrosine-protein phosphatase non-receptor type 11
- CAS No.
- Chemical Name:
- Tyrosine-protein phosphatase non-receptor type 11
- Synonyms
- SHP2;PTP2C;PTN11;PTP-1D;SHPTP2;PTPN11;Noonan syndrome 1;SHP-2 Active human;Protein-tyrosine phosphatase 1D;ANTI-SHP2 antibody produced in rabbit
- CBNumber:
- CB32896224
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MFCD01634179
- MOL File:
- Mol file
| storage temp. | -20°C |
|---|---|
| form | aqueous solution |
| FDA UNII | ZFQG2GI3F2 |
Tyrosine-protein phosphatase non-receptor type 11 price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SRP0217 | SHP-2 Active human recombinant, expressed in E. coli, ≥90% (SDS-PAGE) | 20μG | $480 | 2024-03-01 | Buy | |
| Sigma-Aldrich | SAB4502536 | Anti-SH-PTP2 antibody produced in rabbit affinity isolated antibody | 100μG | $506 | 2024-03-01 | Buy | |
| Sigma-Aldrich | SAB1300500 | Anti-SHP2 antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution | 100μG | $441 | 2024-03-01 | Buy | |
| Usbiological | 031212-PE | PTPN11 | 200ul | $711 | 2021-12-16 | Buy | |
| Usbiological | P9109-29B-AP | PTPN11 | 200ul | $711 | 2021-12-16 | Buy |
Tyrosine-protein phosphatase non-receptor type 11 Chemical Properties,Uses,Production
Uses
Useful for the study of enzyme kinetics, regulation, to dephosphorylate target substrates and for screening inhibitors.
Human active SHP-2 has been used to study the effects of α-lipoic acid and dihydrolipoic acid on the activity of SHP-2 enzyme.
General Description
Protein tyrosine phosphatase, non-receptor type 11 (PTPN11), also known as SHP-2, is a scaffolding protein. It possesses two SH2 domains at the amino terminal, a protein tyrosine phosphatase domain and carboxy-terminal region. The gene encoding SHP-2 is localized on human chromosome 12q24.13.
Biochem/physiol Actions
Protein tyrosine phosphatase, non-receptor type 11 (PTPN11) or SHP-2 is involved in signal transduction pathways downstream of growth receptors. It acts as a proto-oncogene. SHP-2 leads to sustained RAS activation by dephosphorylating the RAS-GTPase-activating protein binding site on Grb2-associated binder 1 (Gab1). This protein also nucleates multiple signaling proteins and thus, acts as an adaptor protein. Mutations in the SHP-2 gene have been associated with Noonan syndrome.
Tyrosine-protein phosphatase non-receptor type 11 Preparation Products And Raw materials
Raw materials
Preparation Products
Tyrosine-protein phosphatase non-receptor type 11 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| AntibodySystem | 17762345272 18162686757 | biolab-reagents@atagenix.com | China | 9818 | 58 |
| ACROBiosystems | 18514007688 | jiaxin.zhao@acrobiosystems.com | China | 987 | 58 |
| United States Biological | -- | sales@advtechind.com | United States | 6106 | 58 |
| Supplier | Advantage |
|---|---|
| AntibodySystem | 58 |
| ACROBiosystems | 58 |
| United States Biological | 58 |