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CCT251545

CAS No.
1661839-45-7
Chemical Name:
CCT251545
Synonyms
CS-2537;CCT251545;LM-3773,CCT251545;CCT-251545;CCT 251545;inhibit,Wnt,CCT251545,Inhibitor,CCT-251545,CCT 251545;8-(3-chloro-5-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one;8-[3-Chloro-5-[4-(1-methyl-1H-pyrazol-4-yl)phenyl]-4-pyridinyl]-2,8-diazaspiro[4.5]decan-1-one;2,8-Diazaspiro[4.5]decan-1-one, 8-[3-chloro-5-[4-(1-methyl-1H-pyrazol-4-yl)phenyl]-4-pyridinyl]-
CBNumber:
CB33067003
Molecular Formula:
C23H24ClN5O
Molecular Weight:
421.92
MDL Number:
MFCD29472582
MOL File:
1661839-45-7.mol
Last updated:2024-07-02 08:55:06

CCT251545 Properties

Boiling point 709.7±60.0 °C(Predicted)
Density 1.37±0.1 g/cm3(Predicted)
storage temp. Inert atmosphere,Store in freezer, under -20°C
solubility ≥42.2 mg/mL in DMSO; insoluble in H2O; ≥2.33 mg/mL in EtOH with ultrasonic
form solid
pka 15.81±0.20(Predicted)
color White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

CCT251545 price More Price(17)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 18761 CCT251545 ≥95% 1661839-45-7 1mg $49 2024-03-01 Buy
Cayman Chemical 18761 CCT251545 ≥95% 1661839-45-7 5mg $190 2024-03-01 Buy
Cayman Chemical 18761 CCT251545 ≥95% 1661839-45-7 10mg $333 2024-03-01 Buy
TRC C227973 CCT251545 1661839-45-7 1mg $100 2021-12-16 Buy
ChemScene CS-5359 CCT251545 99.27% 1661839-45-7 5mg $110 2021-12-16 Buy
Product number Packaging Price Buy
18761 1mg $49 Buy
18761 5mg $190 Buy
18761 10mg $333 Buy
C227973 1mg $100 Buy
CS-5359 5mg $110 Buy

CCT251545 Chemical Properties,Uses,Production

Description

CCT251545 is an orally bioavailable inhibitor of Wnt signaling (IC50 = 5 nM). It is a potent and selective inhibitor of the human mediator complex-associated protein kinases Cdk8 and Cdk19. Through its effects on Cdk8 and Cdk19, CCT251545 alters Wnt pathway-regulated gene expression. It reduces tumor growth in COLO 205 human colon cancer xenografts after oral dosing (70 mg/kg bid) and in Wnt-dependent tumors.

Uses

CCT251545 is a potent inhibitor of WNT signaling with good oral pharmacokinetics.

Definition

ChEBI: CCT251545 is a chloropyridine that is 3-chloropyridine substituted by a 1-oxo-2,8-diazaspiro[4.5]decan-8-yl group and a 4-(1-methyl-1H-pyrazol-4-yl)phenyl group at positions 4 and 5, respectively. It is an orally bioavailable inhibitor of Wnt signaling (IC50 = 5 nM) and a potent and selective chemical probe for cyclin-dependent kinases CDK8 and CDK19. It has a role as a Wnt signalling inhibitor, an antineoplastic agent and an EC 2.7.11.22 (cyclin-dependent kinase) inhibitor. It is a chloropyridine, a member of pyrazoles and an azaspiro compound.

References

[1]. mallinger a, crumpler s, pichowicz m, et al. discovery of potent, orally bioavailable, small-molecule inhibitors of wnt signaling from a cell-based pathway screen. j med chem, 2015, 58(4): 1717-1735.
[2]. dale t, clarke pa, esdar c, et al. a selective chemical probe for exploring the role of cdk8 and cdk19 in human disease. nat chem biol, 2015, 11(12): 973-980.

CCT251545 Preparation Products And Raw materials

Raw materials

Preparation Products

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ATK CHEMICAL COMPANY LIMITED
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Spectrum Chemical Manufacturing Corp. 021-021-021-67601398-809-809-809 15221380277 marketing_china@spectrumchemical.com China 9664 60

CCT251545 Spectrum

CCT251545 8-[3-Chloro-5-[4-(1-methyl-1H-pyrazol-4-yl)phenyl]-4-pyridinyl]-2,8-diazaspiro[4.5]decan-1-one LM-3773,CCT251545 8-(3-chloro-5-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one 2,8-Diazaspiro[4.5]decan-1-one, 8-[3-chloro-5-[4-(1-methyl-1H-pyrazol-4-yl)phenyl]-4-pyridinyl]- CCT-251545;CCT 251545 CS-2537 inhibit,Wnt,CCT251545,Inhibitor,CCT-251545,CCT 251545 1661839-45-7 1661839-45-1 C23H24ClN5O