2-D08
- CAS No.
- 144707-18-6
- Chemical Name:
- 2-D08
- Synonyms
- 2-D08;2-D08 >=98% (HPLC);2',3',4'-Trihydroxyflavone;4H-1-Benzopyran-4-one, 2-(2,3,4-trihydroxyphenyl)-;Ubiquitin ligase,Axl,2-D08,Tyro3,E3 ligating enzyme,Ubiquitin activating enzyme,Inhibitor,E1 activating enzyme,inhibit,2-D-08,2 D08,E1/E2/E3 Enzyme,2D08,E2 conjugating enzyme,Mer,Ubiquitin conjugating enzyme,TAM Receptor
- CBNumber:
- CB33067528
- Molecular Formula:
- C15H10O5
- Molecular Weight:
- 270.24
- MDL Number:
- MOL File:
- 144707-18-6.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P280-P305+P351+P338 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2932990090 | |||||||||
| NFPA 704 |
|
2-D08 price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1052 | 2-D08 ≥98% (HPLC) | 144707-18-6 | 5MG | $115 | 2023-06-20 | Buy |
| Sigma-Aldrich | SML1052 | 2-D08 ≥98% (HPLC) | 144707-18-6 | 25MG | $464 | 2023-06-20 | Buy |
| Cayman Chemical | 20459 | 2-D08 ≥98% | 144707-18-6 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 20459 | 2-D08 ≥98% | 144707-18-6 | 5mg | $100 | 2024-03-01 | Buy |
| Cayman Chemical | 20459 | 2-D08 ≥98% | 144707-18-6 | 10mg | $139 | 2024-03-01 | Buy |
2-D08 Chemical Properties,Uses,Production
Uses
2-D08 has been used as a small ubiquitin-like modifier (SUMO)ylation inhibitor.
Biological Activity
2-d08 (2’,3’,4’-trihydroxyflavone) is a sumoylation inhibitor.protein sumoylation is a dynamic posttranslational modification involved in various biological processes, such as cellular homeostasis and development. sumoylation has been reported to play a key role in cancer, though so far there are few small molecule probes available.
Biochem/physiol Actions
2-D08 is a potent and cell-permeable inhibitor of sumoylation that block the transfer of SUMO (small ubiquitin-like modifier) from the E2 enzyme (Ubc9) thioester conjugate to the substrate.
in vitro
2-d08 was identified as a cell permeable, mechanistically unique inhibitor of protein sumoylation. this compound was found to be able to block sumoylation of topoisomerase i in two different cancer cell lines when co-dosed with camptothecin. in addition, futher analyses indicated that 2-d08 inhibited sumoylation via preventing transfer of small ubiquitin-like modifier (sumo) from the ubc9-sumo thioester to the substrate without affecting sumo-activating enzyme e1 (sae-1/2) or e2 ubc9-sumo thioester formation, a mechanism of action that was unprecedented before [1]. moreover, it was found that 2-d08 at 100 μm could effectively inhibit 10 μm camptothecin induced topoisomerase i sumoylation in breast cancer without affecting overall cellular protein ubiquitinations [2].
References
[1] kim ys, keyser sg, schneekloth js jr. synthesis of 2',3',4'-trihydroxyflavone (2-d08), an inhibitor of protein sumoylation. bioorg med chem lett. 2014 feb 15;24(4):1094-7.
[2] kim ys, nagy k, keyser s, schneekloth js jr. an electrophoretic mobility shift assay identifies a mechanistically unique inhibitor of protein sumoylation. chem biol. 2013 apr 18;20(4):604-13.
2-D08 Preparation Products And Raw materials
Raw materials
Preparation Products
2-D08 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32951 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29811 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38469 | 58 | |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57505 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 18149758185 | sales-cpd@caerulumpharma.com | China | 3466 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51456 | 80 |
| Pharmacodia (Beijing) Co.,Ltd | +86-400-851-9921 | sales@pharmacodia.com | China | 2317 | 55 |
