Niflumic acid
- CAS No.
- 4394-00-7
- Chemical Name:
- Niflumic acid
- Synonyms
- ACTOL;UP-83;sc1332;Forenol;DONALGIN;NIFLURIL;Landruma;niflumic;Niflumate;Niflumicaci
- CBNumber:
- CB3307557
- Molecular Formula:
- C13H9F3N2O2
- Molecular Weight:
- 282.22
- MDL Number:
- MFCD00010569
- MOL File:
- 4394-00-7.mol
- MSDS File:
- SDS
| Melting point | 203-204 °C |
|---|---|
| Boiling point | 378.0±42.0 °C(Predicted) |
| Density | 1.3935 (estimate) |
| storage temp. | 2-8°C |
| solubility | Soluble in ethanol (~50 mg/ml), acetone (50 mg/ml, Clear to Slightly Hazy, Yellow), methanol (~50 mg/ml), DMSO (56 mg/ml at 25°C), and acetonitrile (~50 mg/ml). |
| pka | pKa 2.26 ± 0.08;4.44± 0.03(H2O,t =25±0.1,I=0.01(NaCl))(Approximate) |
| form | Solid |
| color | Light orange to Yellow to Green |
| Water Solubility | 19mg/L(room temperature) |
| Sensitive | Light Sensitive |
| Merck | 14,6531 |
| Stability | Stable, but may discolour in light. Incompatible with strong oxidizing agents. Hygroscopic. |
| InChIKey | JZFPYUNJRRFVQU-UHFFFAOYSA-N |
| EWG's Food Scores | 1 |
| FDA UNII | 4U5MP5IUD8 |
| ATC code | M01AX02,M02AA17 |
| NIST Chemistry Reference | Niflumic acid(4394-00-7) |
| EPA Substance Registry System | 3-Pyridinecarboxylic acid, 2-[[3-(trifluoromethyl)phenyl]amino]- (4394-00-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H413 | |||||||||
| Precautionary statements | P264-P270-P273-P301+P310-P405-P501 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 20/21/22-36/37/38 | |||||||||
| Safety Statements | 26-36-36/37/39 | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | QT2999100 | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | Ⅲ | |||||||||
| HS Code | 29333999 | |||||||||
| Toxicity | LD50 in rats (mg/kg): 370 orally; 155 i.p. (Sorenson) | |||||||||
| NFPA 704 |
|
Niflumic acid price More Price(34)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | N0630 | Niflumic acid | 4394-00-7 | 10g | $71.5 | 2024-03-01 | Buy |
| Sigma-Aldrich | N0630 | Niflumic acid | 4394-00-7 | 25g | $160 | 2024-03-01 | Buy |
| TCI Chemical | T2353 | 2-(3-Trifluoromethylanilino)nicotinic Acid >98.0%(HPLC)(T) | 4394-00-7 | 25g | $120 | 2024-03-01 | Buy |
| Alfa Aesar | J60489 | Niflumic acid, 99+% | 4394-00-7 | 5g | $47.65 | 2024-03-01 | Buy |
| Alfa Aesar | J60489 | Niflumic acid, 99+% | 4394-00-7 | 10g | $81.9 | 2024-03-01 | Buy |
Niflumic acid Chemical Properties,Uses,Production
Chemical Properties
Crystalline Solid
Originator
Nifluril,U.P.S.A.,France,1968
Uses
analgesic, antiinflammatory
Uses
Anti-inflammatory. Selective cyclooxygenase-2 (COX-2) inhibitor
Uses
Niflumic acid is used for the exact same indications as the drugs described above. Synonyms for this drug are actol, flunir, nifluril, and others.
Definition
ChEBI: Niflumic acid is an aromatic carboxylic acid and a member of pyridines.
Manufacturing Process
Niflumic acid is prepared as follows: Nicotinic acid, m-trifluoromethylaniline, and potassium iodide are intimately mixed and heated on an oil bath at 140°C. The mixture melts to give a dark red liquid. The temperature of the oil bath is allowed to fall to 100°C and is maintained at this temperature for an hour and a half. The mixture puffs up and forms a yellow crystalline mass. After cooling to ordinary temperature, this mass is ground up in a mortar and extracted several times with small volumes of ether to remove excess mtrifluoromethylaniline. The residue is then washed twice with 10 ml of distilled water to remove m-trifluoromethylaniline hydrochloride and potassium iodide, and finally twice with 10 ml of 95% alcohol to remove colored resinous contaminants. After drying at 100°C, 2-(m-trifluoromethylanilino)nicotinic acid is obtained as pale yellow needles (from 70% ethanol) melting at 204°C (Kofler block).
Therapeutic Function
Antiinflammatory
Trade name
Actol (Mayrhofer, Austria; Upsamedica, Spain), Donalgin (Gedeon Richter, Hungary), Livornex (Genepharm, Greece), Ni- flam (Upsamedica, Italy), Nifluril (UPSA, France; Upsamedica, Belgium, Switzerland, Portugal).
Biochem/physiol Actions
Niflumic acid (NFA), a γ-aminobutyric acid type A receptor (GABAARs) antagonist is a non-steroidal anti-inflammatory drug (NSAID) and it belongs to the fenamate class. It is also a blocker of chloride ion channel and a calcium-activated chloride channel (CaCC) inhibitor. NFA possesses anti-inflammatory property and is useful in treating rheumatic disorders. It is also an inhibitor of N-methyl-D-aspartate receptor and glycine receptor. NFA also inhibits enzymes associated with the prostaglandins synthesis.
Side effects
Niflumic acid has been used effectively to treat rheumatoid arthritis, psoriatic arthritis, and hypertrophic osteoarthritis of the hip and knee. Gastric complications are the chief adverse effects of this drug.
Synthesis
Niflumic acid, 2-3-(trifluoromethyl)anilino nicotinic acid (3.2.21), is synthesized either by the reaction of 2-chloronicotinic acid with 3-trifluoromethylaniline [84¨C86], or 2-aminonicotinic acid with 1-bromo-3-trifluoromethylbenzene [87].
Niflumic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29791 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29881 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8618959220845 | sales@amoychem.com | China | 6383 | 58 |
| Shandong chuangyingchemical Co., Ltd. | 18853181302 | sale@chuangyingchem.com | CHINA | 5906 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39894 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49374 | 58 |
| SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17365 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32165 | 58 |
View Lastest Price from Niflumic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | Niflumic acid
4394-00-7
|
US $44.00-75.00 / mg | 99.79% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-11-19 | Niflumic acid
4394-00-7
|
US $44.00-75.00 / mg | 99.79% | 10g | TargetMol Chemicals Inc. | ||
 |
2021-07-13 | Niflumic acid
4394-00-7
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- Niflumic acid
4394-00-7
- US $44.00-75.00 / mg
- 99.79%
- TargetMol Chemicals Inc.
-
- Niflumic acid
4394-00-7
- US $44.00-75.00 / mg
- 99.79%
- TargetMol Chemicals Inc.
-
- Niflumic acid
4394-00-7
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd