GPR120 Compound A
- CAS No.
- 1599477-75-4
- Chemical Name:
- GPR120 Compound A
- Synonyms
- MDK-77754;MDK 77754;GPR120 CPDA;GPR120-IN-1;GPR120 Compound A;GPR120 inhibitor 1;GPR120 COMPOUND A HCl;GPR120 CPDA;GPR120-IN-1;MDK-77754;MDK 77754;3-[2-Chloro-5-(trifluoromethoxy)phenyl]-3-azaspiro[5.5]undecane-9-acetic acid;3-Azaspiro[5.5]undecane-9-acetic acid, 3-[2-chloro-5-(trifluoromethoxy)phenyl]-
- CBNumber:
- CB33152620
- Molecular Formula:
- C19H23ClF3NO3
- Molecular Weight:
- 405.84
- MDL Number:
- MOL File:
- 1599477-75-4.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H312-H332 |
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P330-P363-P501 |
GPR120 Compound A price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 16624 | GPR120 Compound A ≥98% | 1599477-75-4 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 16624 | GPR120 Compound A ≥98% | 1599477-75-4 | 5mg | $131 | 2024-03-01 | Buy |
| Cayman Chemical | 16624 | GPR120 Compound A ≥98% | 1599477-75-4 | 10mg | $214 | 2024-03-01 | Buy |
| Cayman Chemical | 16624 | GPR120 Compound A ≥98% | 1599477-75-4 | 50mg | $759 | 2024-03-01 | Buy |
| ApexBio Technology | C5824 | GPR120CompoundA | 1599477-75-4 | 50mg | $866 | 2021-12-16 | Buy |
GPR120 Compound A Chemical Properties,Uses,Production
Biological Activity
gpr120 compound a is an orally active and high-affinity agonist of gpr120 [1].g-protein coupled receptor 120 (gpr120, free fatty acid receptor 4/ffar4) is a g protein-coupled receptor which has been expressed in intestine, adipocytes, and pro-inflammatory macrophages that is activated by long chain free fatty acids. gpr120 has been involved in mediating the anti-inflammatory and insulin-sensitizing effects of omega 3 fatty acids. deficiency of gpr120 is responsible for reduced fat metabolism, produce anti-inflammatory effects and to acutely potentiate insulin secretion [2].gpr120 compound a activated gpr120 with the ec50 value of ~0.35 μm. gpr120 compound a demonstrated potent selectivity over another lipid-sensing g-protein, gpr40 (ffar1). in a high-fat diet fed obese mice, gpr120 compound a (30 mg/kg) exerted anti-inflammatory effects on macrophages in vitro and improved glucose tolerance, decreased hyperinsulinemia, increased insulin sensitivity, and decreased hepatic steatosis [1].
References
[1] walenta e, akiyama t e, lagakos w s, et al. a gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice[j]. nature medicine, 2014, 20(8): 942-947.
[2] ichimura a, hirasawa a, poulain-godefroy o, et al. dysfunction of lipid sensor gpr120 leads to obesity in both mouse and human[j]. nature, 2012, 483(7389): 350-354.
GPR120 Compound A Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32951 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29811 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32112 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52925 | 58 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 18149758185 | sales-cpd@caerulumpharma.com | China | 3466 | 58 |
| Shanghai Beckham Medical Technology Co., Ltd | 021-13816613772 13816613772 | huahero21@sina.com | China | 427 | 55 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8011 | 62 |
| Chuzhou KeMail Chemical Technology Co., Ltd | 0550-5196001 15000891977 | wj520wjxby@126.com | China | 1847 | 55 |
View Lastest Price from GPR120 Compound A manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-12-27 | GPR120 Compound A
1599477-75-4
|
US $1.00 / KG | 1KG | 97%-99.9% | 100kg | Career Henan Chemical Co |
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- GPR120 Compound A
1599477-75-4
- US $1.00 / KG
- 97%-99.9%
- Career Henan Chemical Co