Rp-8-pCPT-Cyclic GMPS (sodium salt)
- CAS No.
- 208445-07-2
- Chemical Name:
- Rp-8-pCPT-Cyclic GMPS (sodium salt)
- Synonyms
- Rp-8-pCPT-cGMPS sodium;Rp-8-pCPT-Cyclic GMPS (sodium salt);Rp-8-pCPT-Cyclic GMPS sodium salt (Rp-8-pCPT-cGMPS);8-[(4-Chlorophenyl)thio]-guanosine-cyclic 3',5'-[hydrogen [P(R)]-phosphorothioate] sodium
- CBNumber:
- CB33152736
- Molecular Formula:
- C16H16ClN5NaO6PS2
- Molecular Weight:
- 527.87
- MDL Number:
- MOL File:
- 208445-07-2.mol
Rp-8-pCPT-Cyclic GMPS (sodium salt) price More Price(4)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 18445 | Rp-8-pCPT-Cyclic GMPS (sodium salt) ≥99% | 208445-07-2 | 1mg | $279 | 2024-03-01 | Buy |
Tocris | 5524 | Rp-8-pCPT-cGMPSsodium ≥99%(HPLC) | 208445-07-2 | 1 | $287 | 2021-12-16 | Buy |
TRC | R700945 | Rp-8-pCPT-CyclicGMPSSodiumSalt | 208445-07-2 | 10mg | $1490 | 2021-12-16 | Buy |
ApexBio Technology | C4394 | Rp-8-pCPT-CyclicGMPS(sodiumsalt) | 208445-07-2 | 1mg | $312 | 2021-12-16 | Buy |
Rp-8-pCPT-Cyclic GMPS (sodium salt) Chemical Properties,Uses,Production
Uses
Rp-8-pCPT-Cyclic GMPS Sodium Salt acts as a stable cell-permeable analog which competetively inhibits cGMP-dependant protein kinases affecting the nervous system.
Biological Activity
rp-8-pcpt-cyclic gmps is a gmp-dependent protein kinases (cgks) inhibitor.appreciation of cgmp as a distinct intracellular second messenger is reported to be closely followed by an intensive search for effector proteins in various organisms. a cgmp-dependent protein kinase (cgk) has been found in arthropods resulting in the eventual isolation of cgk from mammalian tissues.
in vitro
previous study found that rp-8-pcpt-cyclic gmps could selectively inhibit cgk activity in intact human platelets. the ic50 value of rp-8-pcpt-cyclic gmps for cgk ii was 114-fold lower than that for cgk iα in the presence of 1 mm cgmp. in the presence of 10 mm cgmp, the ic50 values of rp-8-pcpt-cyclic gmps for cgk iα and cgk ii increased 3- and 11-fold, respectively. in addition, millimolar concentrations of rp-8-pcpt-cyclic gmps could fully activate both enzymes, a phenomenon that was observed previously for cgk ii. because substitutions at the 8-position of the guanine ring are poorly tolerated by cgk ib, these results suggested that the rp-isomer of 8-pcpt-cgmps might be a selective activator or inhibitor, respectively, of cgk ii compared to the cgk i isoforms [1].
IC 50
18.3 and 0.16 μm for cgk iα and cgk ii, respectively.
storage
Store at -20°C
References
[1] gamm, d. m.,francis, s.h.,angelotti, t.p., et al. the type ii isoform of cgmp-dependent protein kinase is dimeric and possesses regulatory and catalytic properties distinct from the type i isoforms. the journal of biological chemisty 270(45), 27380-27388 (1995).
Rp-8-pCPT-Cyclic GMPS (sodium salt) Preparation Products And Raw materials
Raw materials
Preparation Products
Rp-8-pCPT-Cyclic GMPS (sodium salt) Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 4738 | 58 |
Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11975 | 58 |
United States Biological | -- | sales@advtechind.com | United States | 6106 | 58 |
ApexBio Technology | -- | sales@apexbt.com | United States | 6254 | 58 |