ChemicalBook >> CAS DataBase List >>PE859
PE859
- CAS No.
- 1402727-29-0
- Chemical Name:
- PE859
- Synonyms
- PE859;PE-859; PE 859;AMBZHNVCLPHAKA-NSJFVGFPSA-N;PE 859,PE-859,Inhibitor,inhibit,Microtubule/Tubulin,PE859;1H-Indole, 6-[(1E)-2-[5-[(1E)-2-[2-methoxy-4-(2-pyridinylmethoxy)phenyl]ethenyl]-1H-pyrazol-3-yl]ethenyl]-
- CBNumber:
- CB33161550
- Molecular Formula:
- C28H24N4O2
- Molecular Weight:
- 448.52
- MDL Number:
- MFCD28411710
- MOL File:
- 1402727-29-0.mol
Last updated:2024-07-02 08:55:06
PE859 price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
TRC | M267212 | 6-((E)-2-(3-((E)-2-Methoxy-4-(pyridin-2-ylmethoxy)styryl)-1H-pyrazol-5-yl)vinyl)-1H-indole | 1402727-29-0 | 2.5mg | $800 | 2021-12-16 | Buy |
ChemScene | CS-6428 | PE859 99.84% | 1402727-29-0 | 10mg | $600 | 2021-12-16 | Buy |
ChemScene | CS-6428 | PE859 99.84% | 1402727-29-0 | 1mg | $132 | 2021-12-16 | Buy |
ChemScene | CS-6428 | PE859 99.84% | 1402727-29-0 | 5mg | $396 | 2021-12-16 | Buy |
ChemScene | CS-6428 | PE859 99.84% | 1402727-29-0 | 50mg | $1800 | 2021-12-16 | Buy |
PE859 Chemical Properties,Uses,Production
Uses
6-((E)-2-(3-((E)-2-Methoxy-4-(pyridin-2-ylmethoxy)styryl)-1H-pyrazol-5-yl)vinyl)-1H-indole is a potent tau aggregation inhibitor that functions as a drug for Alzheimer’s disease.
Enzyme inhibitor
This orally bioavailable tau aggregation inhibitor (FW = 448.53 g/mol; IUPAC: 3-[(1E)-2-(1H-indol-6-yl)ethenyl]-5-[(1E)-2-[2-methoxy-4-(2- pyridylmethoxy)phenyl]ethenyl]-1H-pyrazole) significantly reduces formation of sarkosyl-insoluble aggregates of Tau, the principal axonal microtubule-associated protein, and prevents onset and progression of the motor dysfunction in JNPL3 Pro-301-Leu-mutated human tau transgenic mice. PE859 also inhibits aggregation of three-repeat Tau, or 3RMBD-Tau (IC50 = 0.81 μM), and four-repeat Tau, or 2N4R-Tau (IC50 = 2.23 μM).
PE859 Preparation Products And Raw materials
Raw materials
Preparation Products
PE859 Suppliers
Global( 43)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10522 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
Hangzhou ChangCun Biotechnology Co., Ltd. | 0571-; 13567100326 | 158848739@qq.com | China | 108 | 50 |
ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8006 | 62 |
Chuzhou KeMail Chemical Technology Co., Ltd | 0550-5196001 15000891977 | wj520wjxby@126.com | China | 1838 | 55 |
Angel Pharmatech, Ltd. | 17317130613 | 3358272972@qq.com | China | 3249 | 58 |
Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9730 | 58 |
PE859
AMBZHNVCLPHAKA-NSJFVGFPSA-N
PE-859; PE 859
1H-Indole, 6-[(1E)-2-[5-[(1E)-2-[2-methoxy-4-(2-pyridinylmethoxy)phenyl]ethenyl]-1H-pyrazol-3-yl]ethenyl]-
PE 859,PE-859,Inhibitor,inhibit,Microtubule/Tubulin,PE859
1402727-29-0