E3 ligase Ligand-Linker Conjugates 10
- CAS No.
- 1835705-57-1
- Chemical Name:
- E3 ligase Ligand-Linker Conjugates 10
- Synonyms
- VH032-PEG2-C4-Cl;(S,R,S)-AHPC-2-2-6-Cl;VHL Ligand-Linker Conjugates 7;(S,R,S)-AHPC-PEG2-butyl chloride;E3 ligase Ligand-Linker Conjugates 10;L-Prolinamide, N-[2-[2-[(6-chlorohexyl)oxy]ethoxy]acetyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-;(2S,4R)-1-((S)-2-(2-(2-((6-Chlorohexyl)oxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, (S,R,S)-AHPC-2-2-6-Cl, Crosslinker?E3 ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader, VH032 conjugate
- CBNumber:
- CB33386463
- Molecular Formula:
- C32H47ClN4O6S
- Molecular Weight:
- 651.26
- MDL Number:
- MFCD31560480
- MOL File:
- 1835705-57-1.mol
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302-H315-H319-H335 |
Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
E3 ligase Ligand-Linker Conjugates 10 price
E3 ligase Ligand-Linker Conjugates 10 Chemical Properties,Uses,Production
Uses
Protein degrader builiding block (S,R,S)-AHPC-PEG2-Butyl Chloride enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant chloroalkane for reactivity with a nucleophilic group on a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant chloro group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
E3 ligase Ligand-Linker Conjugates 10 Preparation Products And Raw materials
Raw materials
Preparation Products
E3 ligase Ligand-Linker Conjugates 10 Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Xian confluore Biological Technology Co., Ltd. | +86-15680926068 +86-15680926068 | 1924344760@confluore.cn | China | 2996 | 58 |
Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7887 | 56 |
Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
Shanghai Chaolan Chemical Technology Center | QQ:65489617 15618227136 | info@SuperLan-chem.com | China | 9941 | 58 |
Xi'an Confluore Biological Technology Co., Ltd. | +86-156-80926068 +86-15680926068 | 1924344760@qq.com | China | 4824 | 58 |
Jilin Province Woda Biotechnology Co., Ltd. | 13504435624 | 1927928688@qq.com | China | 1382 | 58 |
ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
Zhengzhou convergence chemical co., LTD | 0371-0371-55153829 18003835034 | 2853979819@qq.com | China | 9426 | 58 |
Changzhou Bojia Biomedical Technology Co., Ltd. | 2122619822 | czbjpharma@126.com | China | 18488 | 58 |
View Lastest Price from E3 ligase Ligand-Linker Conjugates 10 manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
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2024-04-02 | (S,R,S)-AHPC-2-2-6-Cl
1835705-57-1
|
US $0.00 / mg | 100mg | >95.00% | 100mg | Xian confluore Biological Technology Co., Ltd. |
-
- (S,R,S)-AHPC-2-2-6-Cl
1835705-57-1
- US $0.00 / mg
- >95.00%
- Xian confluore Biological Technology Co., Ltd.