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E3 ligase Ligand-Linker Conjugates 10

E3 ligase Ligand-Linker Conjugates 10 Structure
E3 ligase Ligand-Linker Conjugates 10 structure
CAS No.
1835705-57-1
Chemical Name:
E3 ligase Ligand-Linker Conjugates 10
Synonyms
VH032-PEG2-C4-Cl;(S,R,S)-AHPC-2-2-6-Cl;VHL Ligand-Linker Conjugates 7;(S,R,S)-AHPC-PEG2-butyl chloride;E3 ligase Ligand-Linker Conjugates 10;L-Prolinamide, N-[2-[2-[(6-chlorohexyl)oxy]ethoxy]acetyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-;(2S,4R)-1-[(2S)-2-(2-{2-[(6-chlorohexyl)oxy]ethoxy}acetamido)-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide;(2S,4R)-1-((S)-2-(2-(2-((6-Chlorohexyl)oxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, (S,R,S)-AHPC-2-2-6-Cl, Crosslinker?E3 ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader, VH032 conjugate
CBNumber:
CB33386463
Molecular Formula:
C32H47ClN4O6S
Molecular Weight:
651.26
MDL Number:
MFCD31560480
MOL File:
1835705-57-1.mol
Last updated:2024-10-23 13:36:13
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E3 ligase Ligand-Linker Conjugates 10 Properties

Boiling point 870.2±65.0 °C(Predicted)
Density 1.218±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO : ≥ 50 mg/mL (76.77 mM)
pka 13.55±0.46(Predicted)
form Oil
color Light yellow to yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P280-P301+P312-P302+P352-P305+P351+P338

E3 ligase Ligand-Linker Conjugates 10 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 905399 (S,R,S)-AHPC-PEG2-butyl chloride 1835705-57-1 50MG $544 2023-06-20 Buy
Iris Biotech GmbH PTC1730 (S,R,S)-AHPC-PEG2-butyl-Cl 1835705-57-1 50mg $634.5 2021-12-16 Buy
Product number Packaging Price Buy
905399 50MG $544 Buy
PTC1730 50mg $634.5 Buy

E3 ligase Ligand-Linker Conjugates 10 Chemical Properties,Uses,Production

Uses

Protein degrader builiding block (S,R,S)-AHPC-PEG2-Butyl Chloride enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant chloroalkane for reactivity with a nucleophilic group on a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant chloro group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

E3 ligase Ligand-Linker Conjugates 10 Preparation Products And Raw materials

Raw materials

Preparation Products

E3 ligase Ligand-Linker Conjugates 10 Suppliers

Global( 13)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32077 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38468 58
Xian confluore Biological Technology Co., Ltd. 		+86-15680926068 +86-15680926068 1924344760@confluore.cn China 2995 58
Sichuan Wei Keqi Biological Technology Co., Ltd. 028-81700200 18116577057 3003855609@qq.com China 7887 56
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51456 80
Xi'an Confluore Biological Technology Co., Ltd. +86-156-80926068 +86-15680926068 1924344760@qq.com China 4824 58
Jilin Province Woda Biotechnology Co., Ltd. 13504435624 1927928688@qq.com China 1388 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11217 58
Zhengzhou convergence chemical co., LTD 0371-0371-55153829 18003835034 2853979819@qq.com China 9718 58
Changzhou Bojia Biomedical Technology Co., Ltd. 2122619822 czbjpharma@126.com China 18478 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
TargetMol Chemicals Inc. 		58
Xian confluore Biological Technology Co., Ltd. 		58
Sichuan Wei Keqi Biological Technology Co., Ltd. 56
Sigma-Aldrich 80
Xi'an Confluore Biological Technology Co., Ltd. 58
Jilin Province Woda Biotechnology Co., Ltd. 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Zhengzhou convergence chemical co., LTD 58
Changzhou Bojia Biomedical Technology Co., Ltd. 58

View Lastest Price from E3 ligase Ligand-Linker Conjugates 10 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(S,R,S)-AHPC-PEG2-C4-Cl pictures 2024-10-24 (S,R,S)-AHPC-PEG2-C4-Cl
1835705-57-1
 US $61.00-98.00 / mg 10g TargetMol Chemicals Inc.
(S,R,S)-AHPC-2-2-6-Cl pictures 2024-04-02 (S,R,S)-AHPC-2-2-6-Cl
1835705-57-1
 US $0.00 / mg 100mg >95.00% 100mg Xian confluore Biological Technology Co., Ltd.
E3 ligase Ligand-Linker Conjugates 10 (S,R,S)-AHPC-PEG2-butyl chloride VH032-PEG2-C4-Cl VHL Ligand-Linker Conjugates 7 L-Prolinamide, N-[2-[2-[(6-chlorohexyl)oxy]ethoxy]acetyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- (S,R,S)-AHPC-2-2-6-Cl (2S,4R)-1-((S)-2-(2-(2-((6-Chlorohexyl)oxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, (S,R,S)-AHPC-2-2-6-Cl, Crosslinker?E3 ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader, VH032 conjugate (2S,4R)-1-[(2S)-2-(2-{2-[(6-chlorohexyl)oxy]ethoxy}acetamido)-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide 1835705-57-1 C32H47ClN4O6S