5-Trifluoromethyl-2-oxindole
- CAS No.
- 71293-62-4
- Chemical Name:
- 5-Trifluoromethyl-2-oxindole
- Synonyms
- 5-(TRIFLUOROMETHYL)OXINDOLE;5-Trifluoromethyl-2-oxindole;5-(Trifluoromethyl)oxindole97%;5-(Trifluoromethyl)oxindole 97%;5-(Trifluoromethyl)-2-oxoindole;5-(Trifluoromethyl)indolin-2-one;5-(TRIFLUOROMETHYL)OXINDOLE ,98%;5-(Trifluoromethyl)-2-oxindole97%;5-(Trifluoromethyl)-2-oxindole 97%;5-(Trifluoromethyl)-1,3-dihydroindol-2-one
- CBNumber:
- CB3341087
- Molecular Formula:
- C9H6F3NO
- Molecular Weight:
- 201.15
- MDL Number:
- MFCD02179602
- MOL File:
- 71293-62-4.mol
- MSDS File:
- SDS
| Melting point | 182-186 |
|---|---|
| Boiling point | 283.4±40.0 °C(Predicted) |
| Density | 1.391±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | Chloroform, DMSO, Methanol (Slightly) |
| form | Solid |
| pka | 13.35±0.20(Predicted) |
| color | Light Brown to Dark Yellow |
| CAS DataBase Reference | 71293-62-4(CAS DataBase Reference) |
5-Trifluoromethyl-2-oxindole price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | T899643 | 5-(Trifluoromethyl)indolin-2-one | 71293-62-4 | 50mg | $45 | 2021-12-16 | Buy |
| TRC | T899643 | 5-(Trifluoromethyl)indolin-2-one | 71293-62-4 | 100mg | $85 | 2021-12-16 | Buy |
| TRC | T899643 | 5-(Trifluoromethyl)indolin-2-one | 71293-62-4 | 500mg | $280 | 2021-12-16 | Buy |
| Matrix Scientific | 188951 | 5-(Trifluoromethyl)indolin-2-one | 71293-62-4 | 1g | $314 | 2021-12-16 | Buy |
| SynQuest Laboratories | 4H48-3-X9 | 5-(Trifluoromethyl)oxindole 97% | 71293-62-4 | 1g | $378 | 2021-12-16 | Buy |
5-Trifluoromethyl-2-oxindole Chemical Properties,Uses,Production
Preparation
STEP A:Preparation of 5-trifluoromethyl-3-methylthio-oxindole To a solution of 15.4 g of p-trifluoromethylaniline in 400 ml. of methylene chloride cooled to minus 65℃. is added dropwise a solution of 10.2 g of t-butyl hypo chlorite in 20 ml. of methylene chloride. The solution is stirred at minus 65℃. for 5 minutes and there is then added dropwise 13.0 g of thioacetic acid ethyl ester in 20 ml of methylene chloride. The resulting mixture is stirred at minus 65℃. for 30 minutes. There is then slowly added 9.8 g of triethylamine and the reaction mixture allowed to warm to room temperature at which time 200 ml of 2 N. hydrochloric acid is added fol lowed by stirring overnight at room temperature. There is then added 20 ml of saturated sodium sulfite solution, the mixture stirred for 15 minutes, the aqueous phase separated and extracted into 1 N sodium hydroxide solution and treated with 6 N. hydrochloric acid to obtain a precipitate. The precipitate is then extracted into methylene chloride, dried, filtered and the methy lene chloride exchanged for ether and then pentane added to obtain 5-trifluoromethyl-3-methylthio-oxin dole, m.p. 136-138℃.STEP B: Preparation of 5-trifluoromethyl-oxindole A mixture of 4.0 g of 5-trifluoromethyl-3-methylthio oxindole, 20g of Raney Nickel and 100 ml. of methanol is refluxed for 4 days, cooled, treated with methylene chloride, filtered to remove the Raney Nickel and the filtrate concentrated in vacuo to obtain 5-trifluorometh yl-oxindole, m.p. 188-190℃.
Uses
5-(Trifluoromethyl)indolin-2-one is a useful reagent for the preparation of 3-Chloro-α-carbolines.
5-Trifluoromethyl-2-oxindole Preparation Products And Raw materials
Raw materials
Preparation Products
5-Trifluoromethyl-2-oxindole Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49374 | 58 |
| Allfluoro pharmaceutical co. ltd. | 021-26137118 +8615821363818 | sales@allfluoro.com | China | 5790 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30240 | 58 |
| KARMEL TECHNOLOGY (HK) CO.,LIMITED | +8618795957998 | karmelhk@126.com | CHINA | 2886 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | China | 52849 | 58 |
| CR Corporation Limited | +8613062833949 | fred.wen@crcorporation.cn | China | 8647 | 58 |
| PT CHEM GROUP LIMITED | peter68@ptchemgroup.com | China | 35425 | 58 |
71293-62-4(5-Trifluoromethyl-2-oxindole)Related Search:
1of4