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22(R)-HYDROXYCHOLESTEROL

22(R)-HYDROXYCHOLESTEROL structure

CAS No.: 17954-98-2

Chemical Name:: 22(R)-HYDROXYCHOLESTEROL

Synonyms: 22R-OHC;22(R)-OH-CH;Narthesterol;22α-hydroxycholesterol;22BF-HYDROXYCHOLESTEROL;Cholesterol 22α-Hydroxy;22α-Hydroxy Cholesterol;22(R)-Hydroxycholestero;Chlorambucil Impurity 8;22(R)-HYDROXYCHOLESTEROL

CBNumber:: CB3350290

Molecular Formula:: C27H46O2

Molecular Weight:: 402.65

MDL Number:: MFCD00070042

MOL File:: 17954-98-2.mol

MSDS File:: SDS

Last updated:2023-05-18 11:31:14

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22(R)-HYDROXYCHOLESTEROL Properties

Melting point	171-174°C
Boiling point	513.1±23.0 °C(Predicted)
Density	1.03±0.1 g/cm3(Predicted)
storage temp.	-20°C
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Solid
pka	15.01±0.20(Predicted)
color	White to Off-White
InChIKey	RZPAXNJLEKLXNO-QUOSNDFLSA-N

SAFETY

Risk and Safety Statements

WGK Germany	3

22(R)-HYDROXYCHOLESTEROL price More Price(11)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	H9384	22(R)-Hydroxycholesterol ≥98%	17954-98-2	1mg	$110	2024-03-01	Buy
Sigma-Aldrich	H9384	22(R)-Hydroxycholesterol ≥98%	17954-98-2	5mg	$418	2024-03-01	Buy
Cayman Chemical	89355	22(R)-hydroxy Cholesterol ≥98%	17954-98-2	1mg	$61	2024-03-01	Buy
Cayman Chemical	89355	22(R)-hydroxy Cholesterol ≥98%	17954-98-2	5mg	$264	2024-03-01	Buy
Cayman Chemical	89355	22(R)-hydroxy Cholesterol ≥98%	17954-98-2	10mg	$468	2024-03-01	Buy

Product number	Packaging	Price	Buy
H9384	1mg	$110	Buy
H9384	5mg	$418	Buy
89355	1mg	$61	Buy
89355	5mg	$264	Buy
89355	10mg	$468	Buy

22(R)-HYDROXYCHOLESTEROL Chemical Properties,Uses,Production

Description

The liver X receptors (LXRα and LXRβ) are nuclear hormone receptors whose native ligands are oxysterols. LXRs regulate the oxysterol-induced expression of cholesterol 7α-hydroxylase, the rate limiting enzyme of classic bile acid synthesis. 22(R)-hydroxy Cholesterol is an endogenous agonist for LXRs that activates LXRα with an EC₅₀ value of 325 nM. 22(R)-hydroxy Cholesterol, acting through LXR heterodimerized with the retinoid X receptor, induces the expression of the ABCA1 reverse cholesterol transporter. This activity increases the efflux of cholesterol from enterocytes and thus inhibits the overall absorption of cholesterol. 22(R)-hydroxy Cholesterol can be used as a substrate to monitor cholesterol transport or as an endogenous positive control for testing LXR agonists which have potential as therapeutic agents for the treatment of atherosclerosis.

Uses

The 22R-metabolite of Cholesterol (C432501). 22-Hydroxycholesterol inhibits chemokine receptor activity.

Uses

Bovine aortic endothelial cells were treated with 22(R)-Hydroxycholesterol to study the effects on production of free radicals and in studies related to fatty acid metabolism.

Definition

ChEBI: An oxysterol that is the 22R-hydroxy derivative of cholesterol.

General Description

22(R)-hydroxycholesterol is a diastereomer of 22(S)-hydroxycholesterol. It is present in neonate brain.

Biochem/physiol Actions

22(R)-hydroxycholesterol (22(R)-HC) is a liver X receptor (LXR) ligand.. 22(R)-HC in combination with other oxysterols promote mesenchymal stem cell osteogenesis. It regulates cholesterol homeostasis. Low levels of 22(R)-HC is observed in Alzheimer′s disease and it may be implicated in neuroinflammation and neurodegenerative diseases. 22(R)-hydroxycholesterol also suppresses prostate tumor progression.

22(R)-HYDROXYCHOLESTEROL Preparation Products And Raw materials

Raw materials

Preparation Products

22(R)-HYDROXYCHOLESTEROL Suppliers

Global( 66)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	18777	58
Dayang Chem (Hangzhou) Co.,Ltd.	571-88938639 +8617705817739	info@dycnchem.com	China	52849	58
Henan Aochuang Chemical Co.,Ltd.	+86-0371-63689365 +8618638391208	sales@aochuangchem.com	China	9237	58
GIHI CHEMICALS CO.,LIMITED	+8618058761490	info@gihichemicals.com	China	49978	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+undefined18621343501	product@acmec-e.com	China	33338	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57505	58
SHANGHAI KEAN TECHNOLOGY CO., LTD.	+8613817748580	cooperation@kean-chem.com	China	40066	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131957	58
Shanghai Boyle Chemical Co., Ltd.	021-50182298 021-50180596	sales@boylechem.com	China	2208	55
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	94657	76

Supplier	Advantage
Shanghai Daken Advanced Materials Co.,Ltd	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Henan Aochuang Chemical Co.,Ltd.	58
GIHI CHEMICALS CO.,LIMITED	58
Shanghai Acmec Biochemical Technology Co., Ltd.	58
Aladdin Scientific	58
SHANGHAI KEAN TECHNOLOGY CO., LTD.	58
Amadis Chemical Company Limited	58
Shanghai Boyle Chemical Co., Ltd.	55
J & K SCIENTIFIC LTD.	76

View Lastest Price from 22(R)-HYDROXYCHOLESTEROL manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2022-10-20	22(R)-HYDROXYCHOLESTEROL 17954-98-2	US $0.00-0.00 / KG	1KG	98%	1ton	Henan Aochuang Chemical Co.,Ltd.

22(R)-HYDROXYCHOLESTEROL
17954-98-2
US $0.00-0.00 / KG
98%
Henan Aochuang Chemical Co.,Ltd.

22(R)-HYDROXYCHOLESTEROL Spectrum

22(R)-HYDROXYCHOLESTEROL(17954-98-2)¹HNMR

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22(R)-HYDROXYCHOLESTEROL 5-CHOLESTENE 5,20-ALPHA, 22-ALPHA, 25D-SPIROSTEN-3-BETA-OL ACETATE

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22α-Hydroxycholesterol, 5-Cholestene-3β,22(R)-diol, 5-Cholestene-3β,22[R]-diol (22R)-Cholest-5-ene-3β,22-diol 22R-OHC (3beta,22R)-Cholest-5-ene-3,22-diol Cholest-5-ene-3,22-diol, (3beta,22R)- (20S,22R)-Cholest-5-ene-3β,22-diol (3β,22R)-Cholest-5-ene-3,22-diol Cholest-5-ene-3β,22(R)-diol Narthesterol 5-Cholestene-3β,22(R)-diol 5-Cholestene-3β,22[R]-diol 22BETA-HYDROXYCHOLESTEROL 22BF-HYDROXYCHOLESTEROL 22-ALPHA-HYDROXYCHOLESTEROL 22(R)-HYDROXYCHOLESTEROL 22(R)-OH-CH 22-HYDROXYCHOLESTEROL (22R) 3BETA,22BETA-DIHYDROXY-5-CHOLESTENE 5-CHOLESTEN-3-BETA, 22(R)-DIOL 5-CHOLESTENE-3BETA,22[R]-DIOL CHOLEST-5-ENE-3BETA,22R-DIOL 22[R]-Hydroxycholesterol (not deuterated) 22α-hydroxycholesterol (22a-Hydroxycholesterol, 5-Cholestene-322(R)-diol) Cholesterol 22α-Hydroxy 22α-Hydroxy Cholesterol 22(R)-Hydroxycholestero Cholest-5-ene-3,22-diol, (3β,22R)- 5-CHOLESTEN-3β, 22(R)-DIOL Chlorambucil Impurity 8 17954-98-2 Lipids Sterols Cholesterol and Derivatives BioChemical Biochemicals and Reagents Hydroxycholesterol Intermediates & Fine Chemicals Metabolites & Impurities Pharmaceuticals Steroids