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ANTALARMIN HYDROCHLORIDE

ANTALARMIN HYDROCHLORIDE structure

CAS No.: 220953-69-5

Chemical Name:: ANTALARMIN HYDROCHLORIDE

Synonyms: Antalarmin hydrochlo;ANTALARMIN HYDROCHLORIDE;N-Butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-aminehydrochloride;7H-Pyrrolo[2,3-d]pyrimidin-4-amine,N-butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-,hydrochloride;N-BUTYL-N-ETHYL-2,5,6-TRIMETHYL-7-(2,4,6-TRIMETHYLPHENYL)-7H-PYRROLOL[2,3-D]PYRIMIDIN-4-AMINE HYDROCHLORIDE;N-Butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolol[2,3-d]pyrimidin-4-amine hydrochloride;7H-Pyrrolo[2,3-d]pyrimidin-4-amine,N-butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-, hydrochloride (1:1)

CBNumber:: CB3352845

Molecular Formula:: C24H35ClN4

Molecular Weight:: 415.02

MDL Number:: MFCD05664721

MOL File:: 220953-69-5.mol

MSDS File:: SDS

Last updated:2023-09-04 15:51:00

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ANTALARMIN HYDROCHLORIDE Properties

storage temp.	2-8°C
solubility	DMSO: ~24 mg/mL, soluble
form	solid
color	off-white

SAFETY

Risk and Safety Statements

Safety Statements	22-24/25
WGK Germany	3

ANTALARMIN HYDROCHLORIDE price More Price(14)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	A8727	Antalarmin hydrochloride ≥98% (HPLC), solid	220953-69-5	10mg	$270	2024-03-01	Buy
Sigma-Aldrich	A8727	Antalarmin hydrochloride ≥98% (HPLC), solid	220953-69-5	50mg	$924	2024-03-01	Buy
Cayman Chemical	15147	Antalarmin (hydrochloride) ≥98%	220953-69-5	5mg	$110	2024-03-01	Buy
Cayman Chemical	15147	Antalarmin (hydrochloride) ≥98%	220953-69-5	10mg	$153	2024-03-01	Buy
Cayman Chemical	15147	Antalarmin (hydrochloride) ≥98%	220953-69-5	25mg	$326	2024-03-01	Buy

Product number	Packaging	Price	Buy
A8727	10mg	$270	Buy
A8727	50mg	$924	Buy
15147	5mg	$110	Buy
15147	10mg	$153	Buy
15147	25mg	$326	Buy

ANTALARMIN HYDROCHLORIDE Chemical Properties,Uses,Production

Description

Corticotropin-releasing hormone (CRH) secreted from the hypothalamus is the major regulator of pituitary corticotropin-release and consequent glucocorticoid secretion. Antalarmin is a selective, nonpeptide antagonist of the CRH receptor 1 (K_i = 1 nM) that, consequently, reduces the release of corticotropin in response to chronic stress. Through its antagonism of central CRH signaling, antalarmin can reduce endocrinological, cardiovascular, and behavioral responses to stressful stimuli. It has also been shown to reduce dose escalation in cocaine-addicted rats, to produce anti-inflammatory effects in arthritis models, and to suppress stress-induced gastric ulceration related to irritable bowel syndrome.

Uses

Antalarmin hydrochloride is a non-peptide CRF1 corticotropin-releasing factor receptor antagonist.

Biological Activity

Non-peptide corticotropin-releasing hormone receptor 1 (CRF 1 ) antagonist (K i = 1 nM). Suppresses CRF-induced ACTH secretion. Blocks CRF- and novelty-induced anxiety-like behavior in animal models of anxiety.

Biochem/physiol Actions

Antalarmin serves as a non steroidal inhibitor of pregnancy even during the early stages. It is known to delay parturition. It also prevents the development of gastric ulcers which arises in response to stress.

storage

Desiccate at +4°C

ANTALARMIN HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

ANTALARMIN HYDROCHLORIDE Suppliers

Global( 33)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21669	55
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3136	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57511	58
Nantong Hi-Future Biotechnology Co., Ltd	18051384581	sales@chemhifuture.com	China	3058	58
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15848	69
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80
EMMX Biotechnology LLC	888-539-0666	info@emmx.com	United States	8449	60
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9707	58
Shanghai Chaolan Chemical Technology Center	QQ:65489617 15618227136	info@SuperLan-chem.com	China	9909	58

Supplier	Advantage
Henan Tianfu Chemical Co.,Ltd.	55
TargetMol Chemicals Inc.	58
Nantong HI-FUTURE Biology Co., Ltd.	58
Aladdin Scientific	58
Nantong Hi-Future Biotechnology Co., Ltd	58
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Sigma-Aldrich	80
EMMX Biotechnology LLC	60
Shanghai EFE Biological Technology Co., Ltd.	58
Shanghai Chaolan Chemical Technology Center	58

ANTALARMIN HYDROCHLORIDE Spectrum

ANTALARMIN HYDROCHLORIDE(220953-69-5)¹HNMR

ANTALARMIN HYDROCHLORIDE N-BUTYL-N-ETHYL-2,5,6-TRIMETHYL-7-(2,4,6-TRIMETHYLPHENYL)-7H-PYRROLOL[2,3-D]PYRIMIDIN-4-AMINE HYDROCHLORIDE N-Butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolol[2,3-d]pyrimidin-4-amine hydrochloride N-Butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-aminehydrochloride 7H-Pyrrolo[2,3-d]pyrimidin-4-amine,N-butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-,hydrochloride Antalarmin hydrochlo 7H-Pyrrolo[2,3-d]pyrimidin-4-amine,N-butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-, hydrochloride (1:1) 220953-69-5 C24H34N4HCl