N-(2-hydroxy-5-methylphenyl)-3-phenylpropanamide
- CAS No.
- 393121-74-9
- Chemical Name:
- N-(2-hydroxy-5-methylphenyl)-3-phenylpropanamide
- Synonyms
- AA147 (AA 147;AA147 >=98% (HPLC);ATF6-activator-147;ATF6-activator-147 (AA147);ATF6 agonist compound A147;N-(2-Hydroxy-5-methylphenyl)benzenepropanamide;N-(2-hydroxy-5-methylphenyl)-3-phenylpropanamide;Benzenepropanamide, N-(2-hydroxy-5-methylphenyl)-;neurodegenerative disorders,SMA,AA147,ATF6,BPAEC,NRF2,AA 147,Inhibitor,AA-147,inhibit,ROS
- CBNumber:
- CB33545952
- Molecular Formula:
- C16H17NO2
- Molecular Weight:
- 255.31
- MDL Number:
- MOL File:
- 393121-74-9.mol
| Boiling point | 460.8±40.0 °C(Predicted) |
|---|---|
| Density | 1.190±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Soluble in DMSO (>25 mg/ml); ethanol (>25 mg/mL) |
| form | solid |
| pka | 9.68±0.48(Predicted) |
| color | Beige to pale orange |
| Stability | Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
N-(2-hydroxy-5-methylphenyl)-3-phenylpropanamide price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| American Custom Chemicals Corporation | CHM0196190 | N-(2-HYDROXY-5-METHYLPHENYL)-3-PHENYLPROPANAMIDE 95.00% | 393121-74-9 | 5MG | $503.06 | 2021-12-16 | Buy |
| DC Chemicals | DC21979 | ATF6agonistcompoundA147 >98% | 393121-74-9 | 1g | $1800 | 2021-12-16 | Buy |
N-(2-hydroxy-5-methylphenyl)-3-phenylpropanamide Chemical Properties,Uses,Production
Description
AA147 (393121-74-9) is a preferential activator of the ER stress sensing protein ATF6.1 It was able to selectively reduce secretion and extracellular aggregation of destabilized amyloidogenic variants of TTR and LC proteins. AA147-dependent ATF6 activation proceeds via metabolic activation to a reactive electrophile that selectively modifies ER proteins including multiple protein disulfide isomerases.2? AA147 suppressed pluripotency and promoted human stem cell differentiation toward a mesodermal lineage via ER expansion.3? It protected the heart against ischemia/reperfusion (I/R) injury in a mouse model of acute myocardial infarction in an ATF6-dependent manner.4 Brain, kidney, and liver tissue was also protected from I/R damage and impaired proteostasis. AA147 reduced infection of multiple strains of dengue and Zika viruses in an ATF6-independent manner.5 Protects against glutamate-induced cell death is a neuronal-derived cell culture model.6 See companion inhibitor 10-3974.
storage
Store at +4°C
References
Plate et al. (2016), Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation; Elife 5 e15550 Paxman et al. (2018), Pharmacologic ATF6 activating compounds are metabolically activated to selectively modify endoplasmic reticulum, proteins; Elife 7 e37168 Kroeger et al. (2018), The unfolded protein response regulator ATF6 promotes mesodermal differentiation; Sci. Signal. 11 eaan5785 Blackwood et al. (2019), Pharmacological ATF6 activation confers global protection in widespread disease models by reprogramming cellular proteostasis; Nat. Commun. 10 187 Almasy et al. (2021), Small molecule endoplasmic reticulum proteostasis regulator acts as a broad-spectrum inhibitor of dengue and Zika virus infections; Proc. Natl. Acad. Sci. USA 118 e2012209118 Rosardo et al. (2021), Metabolically Activated Proteostasis Regulators against Glutamate Toxicity by Activating NRF2; ACS Chem. Biol. 16 2852
N-(2-hydroxy-5-methylphenyl)-3-phenylpropanamide Preparation Products And Raw materials
Raw materials
Preparation Products
N-(2-hydroxy-5-methylphenyl)-3-phenylpropanamide Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9926 | 65 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9707 | 58 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 3730 | 55 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |
| DC Chemicals | 021-58447131 13564518121 | sales@dcchemicals.com | China | 9412 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44843 | 58 |